Table 5 Summary of cII mutation spectra induced by 2,5- and 2,6- DMAs in the nasal tissues

Base Substitution

36

(80)

50

(88)

34

(97)

 Transitions

30

(67)

37

(65)

19

(54)

  GC to AT

29 [20]^a

(64)

27* [19]

(47)

14* [11**]

(40)

  AT to GC

1

(2)

10*

(18)

5

(14)

 Transversions

6

(13)

13

(23)

15

(43)

  AT to TA

2

(4)

2

(4)

2

(6)

  AT to CG

2

(4)

0

(0)

3

(9)

  GC to TA

0

(0)

7*

(12)

6*

(17)

  GC to CG

2

(4)

4

(7)

4

(11)

-1 frameshifts

2

(4)

4

(7)

0

(0)

+ 1 frameshifts

7

(16)

2

(4)

1

(3)

Deletion

0

(0)

0

(0)

0

(0)

Insertion

0

(0)

1

(2)

0

(0)

Complex

0

(0)

0

(0)

0

(0)

Total

45

(100)

57

(100)

35

(100)