Table 1 The FA gene products and their functions
From: Importance of finding the bona fide target of the Fanconi anemia pathway
FA protein (alias) | Function |
|---|---|
FANCA | FA core complex |
FANCB | FA core complex |
FANCC | FA core complex |
FANCD1 (BRCA2) | Homologous recombination |
FANCD2 | ID complex |
FANCE | FA core complex |
FANCF | FA core complex |
FANCG | FA core complex |
FANCI | ID complex |
FANCJ (BRIP1) | Homologous recombination |
FANCL | FA core complex, ubiquitin ligase |
FANCM | FA core complex, helicase |
FANCN (PALB2) | Homologous recombination |
FANCO (RAD51C) | Homologous recombination |
FANCP (SLX4) | ICL unhooking |
FANCQ (ERCC4/XPF) | ICL unhooking, structure-specific endonuclease |
FANCR (RAD51) | Homologous recombination |
FANCS (BRCA1) | Homologous recombination |
FANCT (UBE2T) | Ubiquitin-conjugating enzyme |
FANCU (XRCC2) | Homologous recombination |
FANCV (MAD2L2/REV7) | Translesion synthesis |
FANCW (RFWD3) | Homologous recombination, ubiquitin ligase |