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Table 2 Mutagenic potencies of tested compounds in standard TA1535 and TA100 versus new Ames tester strains overexpressing the episomal Y-family DNA polymerases. Data from tests conducted in the presence of the lac promoter inducer as described under Material and Methods are added for comparison in the columns under the IPTG label. The lac promoter drives the expression of the activated forms of DNA polymerases RI* and SamA’B overexpressed in the strains YG9028 and YG9029, respectively

From: Effect of episomally encoded DNA polymerases on chemically induced mutagenesis at the hisG46 target in Ames test

CompoundSpecific mutagenicity [revertants/plate/nmole]
TA1535TA100YG9028YG9029
 IPTG IPTG IPTG IPTG
AF-2 *)18,78816,38110,697511319613723
MMS0.1030.0990.205
AFB1846692
1,8-DNP38,46553,0332595neg.378214,195
AG1.0471.1510.8170.6460.420.1280.7530.464
  1. *) only zero plus 2 first doses used for the calculations due to nonlinearity at higher doses