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Table 1 Antimutagenic activity of coumarins (1 and 2), limonoids (19 and 20), oxime and synthetic intermediates (21, 21a, and 21b), ent-kaurane diterpenoids (25, 26, 29, 30, and 33), and onoceranoid-type triterpenoids (44, 4649, 53, and 54) against Trp-P-1 (0.04 μg/plate) using the Ames test [4,5,6,7,8]a

From: Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents

  Inhibition % (Based on number of revertant colonies)
50 nmol/plate 100 nmol/plate 200 nmol/plate 400 nmol/plate 800 nmol/plate
Coumarins
1b 45.8% 58.7% 64.6% 75.6% 82.3%
2b 57.8% 59.8% 67.1% 77.2% 81.4%
Limonoids
19b 10.7% 8.0% 31.0% 46.0% 45.8%
20b 38.7% 54.9% 69.8% 83.1%  
Oxime
21b 27.3% 26.2% 40.5% 53.7% 49.0%
Synthetic intermediates of 21
21ab 22.2% 20.6% 21.6% 0.2%
21bb 31.7% 39.2% 51.7% 54.7% 61.4%
ent-Kaurane diterpenoids
25b 34.6% 57.3% 53.7% 65.2%  
26b 32.9% 54.4% 60.9% 67.8%  
29b 21.0% 47.5% 52.0% 59.9%  
30b 46.0% 56.8% 72.8% 73.3%  
33b 41.0% 54.9% 68.3%   
Onoceranoid-type triterpenoids
44c 11% 25% 50% 88%  
46b 14% 23% 41% 65%  
47b 73.8% 90.5% 94.2%  
48b 0.4% 29.5% 64.8% 77.5%  
49b 3.7% 7.9% 8.7% 42.6%  
53b 5.1% 79.9% 91.5% 92.4%  
54c 25.0% 61.0% 93.0%  
  1. a Nobiletin was used as a reference compound. It showed 56% inhibition at 20 nmol/plate
  2. b Compounds showed no antibacterial activity [< 5.0% inhibition at highest concentration] against the S. typhimurium TA98 strain
  3. c Compounds showed weak antibacterial activity [44: 23.2% inhibition at 400 nmol/plate, 54: 23.0% inhibition at 400 nmol/plate] against the S. typhimurium TA98 strain