Table 1 Antimutagenic activity of coumarins (1 and 2), limonoids (19 and 20), oxime and synthetic intermediates (21, 21a, and 21b), ent-kaurane diterpenoids (25, 26, 29, 30, and 33), and onoceranoid-type triterpenoids (44, 46–49, 53, and 54) against Trp-P-1 (0.04 μg/plate) using the Ames test [4,5,6,7,8]a
Inhibition % (Based on number of revertant colonies) | |||||
|---|---|---|---|---|---|
50 nmol/plate | 100 nmol/plate | 200 nmol/plate | 400 nmol/plate | 800 nmol/plate | |
Coumarins | |||||
1b | 45.8% | 58.7% | 64.6% | 75.6% | 82.3% |
2b | 57.8% | 59.8% | 67.1% | 77.2% | 81.4% |
Limonoids | |||||
19b | 10.7% | 8.0% | 31.0% | 46.0% | 45.8% |
20b | 38.7% | 54.9% | 69.8% | 83.1% | |
Oxime | |||||
21b | 27.3% | 26.2% | 40.5% | 53.7% | 49.0% |
Synthetic intermediates of 21 | |||||
21ab | 22.2% | 20.6% | 21.6% | 0.2% | – |
21bb | 31.7% | 39.2% | 51.7% | 54.7% | 61.4% |
ent-Kaurane diterpenoids | |||||
25b | 34.6% | 57.3% | 53.7% | 65.2% | |
26b | 32.9% | 54.4% | 60.9% | 67.8% | |
29b | 21.0% | 47.5% | 52.0% | 59.9% | |
30b | 46.0% | 56.8% | 72.8% | 73.3% | |
33b | 41.0% | 54.9% | 68.3% | ||
Onoceranoid-type triterpenoids | |||||
44c | 11% | 25% | 50% | 88% | |
46b | 14% | 23% | 41% | 65% | |
47b | – | 73.8% | 90.5% | 94.2% | |
48b | 0.4% | 29.5% | 64.8% | 77.5% | |
49b | 3.7% | 7.9% | 8.7% | 42.6% | |
53b | 5.1% | 79.9% | 91.5% | 92.4% | |
54c | – | 25.0% | 61.0% | 93.0% | |