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Table 1 All of the ECM related factors involved in gastric cancer progression and metastasis

From: Role of extra cellular proteins in gastric cancer progression and metastasis: an update

Gene Results Country population Year Reference
ECM modifying enzymes
 MMP9 Polymorphism was correlated with invasive phenotype Japan 177 patients
224 controls
2005 Matsumura [32]
 MMP9 MMP9 expression was correlated with stage, depth of tumor invasion, and lymph node involvement Poland 54 patients 2009 Mroczko [33]
 MMP9 increased levels of expression in advanced stage tumors Serbia 40 patients
11 controls
2009 Dragutinovic [34]
 MMP1 Polymorphism was correlated with poorly differentiation Japan 215 patients
166 controls
2004 Matsumura [35]
 MMP1 Polymorphism was correlated with GC risk China 422 patients
428 controls
2014 Dedong [36]
 MMP2 MMP2 expression was correlated with poor survival, stage, and diffuse type Finland 315 patients 2006 Mrena [37]
 MMP14 High levels of serum MMP14 was correlated with poor survival Finland 240 patients 2018 Kasurinen [38]
 MMP7 and LAMC2 MMP7 and LAMC2 expressions were correlated with tumor aggressiveness Japan 790 patients 2014 Sentani [39]
 ADAMTS8, ADAMTS18, and ADAMTS1 Expressions were correlated with stage Turkey 25 patients 2017 Kilic [40]
 TIMP1 TIMP1 expression was correlated with advanced stages, increased depth of invasion, and metastatic lymph nodes Poland 54 patients 2009 Mroczko [41]
 MMP2, MMP24, and MMP25 MMP2, MMP24, and MMP25 increased expression Mexico 17 patients
22 controls
2014 De la pena [42]
 LOX Over expression was correlated with local tumor relapse China 184 patients 2018 Peng [43]
 LOXL4 Over expression was correlated with tumor size, depth of invasion, stage, and survival China 379 patients 2015 Li [44]
 PLOD2 Expression was correlated with peritoneal metastasis Japan 179 patients 2018 Kiyozumi [45]
 TFPI2 Hyper methylation China 114 patients 2017 Hu [46]
 ETS1 over expression induced mucosal into the sub mucosal tumor invasion Japan 110 patients 1996 Nakayama [47]
Extra cellular angiogenic factors
 BSG Expression was correlated with tumor size and lymph node metastasis Japan 234 tumors
85 normal
2006 Zheng [48]
 MMRN2, EMILIN1, and EMILIN2 High expression of MMRN2 in normal gastric mucosa along blood vessels, while the EMILIN2 and EMILIN1 expressions were limited to the lamina propria. Italy 51 patients 2018 Andreuzzi [49]
 HPSE Polymorphism was correlated with survival China 155 patients
204 controls
2010 Yue [50]
 CTHRC1 Expression was correlated with depth of invasion China 116 patients 2012 Wang [51]
 CTHRC1 Expression was associated with tumor stage, differentiation, survival, and prognosis, depth of invasion, lymph node involvement, and tumor size. China 166 tumors
30 normal
2014 Gu [52]
 ECM1 Expression was correlated with tumor relapse, poor survival, and advanced stages. China 241 patients 2018 Gan [53]
 ECM1 Expression was correlated with tumor depth of invasion and stage. China 77 patients 2014 Wu [54]
Cell adhesion and cytoskeletal organizers
 PCDH8 Was correlated with poor prognosis. China 144 patients 2018 Lin [55]
 CLDN4 Expression was correlated with depth of invasion and lymph node involvement Taiwan 189 patients 2010 Hwang [56]
 LLGL1 Was correlated with distant metastasis. Germany 56 patients 2019 Desuki [57]
 FN1 increased serum levels Turkey 63 patients
30 controls
2016 Tas [58]
 FNDC1 Expression was correlated with sex, survival, and stage. China 90 patients 2018 Ren [59]
 ANOS1 Expression was correlated with stage and prognosis. Japan 237 patients 2016 Kanda [60]
 ITGA4 Methylation Korea 46 patients 2004 Park [61]
 ICAM1 (CD54) Expressions were correlated with stage and lymph node involvement. China 84 patients 2014 Dong [62]
 CFL1 Over expression China 33 patients 2017 Wang [63]
 HMMR (CD168) Inverse correlation with lymph node involvement. Japan 196 patients 2011 Ishigami [64]
 MFAP2 Expression was correlated with depth of invasion, lymph node involvement, tumor stage, and poor overall survival China 168 patients 2018 Wang [65]
 SPON2 Expression was correlated with grade of tumor differentiation, depth of invasion, lymph node involvement, and advanced stages. China 174 patients 2017 Jin [66]
Matricellular proteins and growth factors
 SPARC Was correlated with serosal invasion and poor survival. Japan 227 patients 2013 Sato [67]
 SERPINE1 AND SPARC Expressions were correlated with poor survival. China 293 tumors
196 normal
2018 Liao [68]
 SPARCL1 Expression was correlated with prognosis, survival, size, and grade. China 1072 patients 2012 Li [69]
 FGFR2 AND THBS1 Over expressions China 53 patients 2017 Huang [70]
 LTBP2 Expression was correlated with depth of invasion, stage, lymph node involvement, poor survival. China 174 patients 2018 Wang [71]
 POSTN Inverse correlation between expression and stage. China 25 tumors
8 normal
2014 LV [72]
Proteoglycans and extra cellular glycoproteins
 VCAN Expression was correlated with poor prognosis. China 101 patients 2015 Shen [73]
 ASPN Over expression. China 46 patients 2015 Ding [74]
 LUM Up regulation in gastric CAFs was correlated with advanced stage, poor survival, depth of invasion, and lymph node involvement. China 117 patients 2017 Wang [75]
 MUC2 Was correlated with grade. Egypt 28 patients 2011 Khattab [76]