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Table 2 EC50 values (μM) of synthetic ligands in yeast strains expressing human ERα, ERβ, and AR

From: Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids

Receptor Strains Ligands
E2* EE2 DES PPT DPN
ERα W303a 7.66 × 10−4 6.34 × 10−4 4.20 18.42 26.04
cwp1Δcwp2Δ 8.34 × 10−5 4.22 × 10−5 3.91 0.92 3.16
ERβ W303a 1.89 × 10−4 6.59 × 10− 4 8.31 × 10− 4 13.71 3.54
cwp1Δcwp2Δ 5.89 × 10− 5 1.76 × 10− 5 8.50 × 10− 4 2.34 0.089
Receptor Strains Ligands
17α-MAS 17β-H 17α -MTS TBA STA EE2
AR W303a 0.010 0.032 11.6 0.10 0.019 6.47
cwp1Δpdr5Δ 0.027 0.019 0.078 0.031 0.022 2.88
pdr5Δpdr10Δ 3.10 × 10−3 0.016 0.023 0.75 0.021 1.88
  1. * Dose-response curve of ERα- and ERβ-expressing yeast strains against E2 assayed in exposure condition for synthetic estrogens was presented in Fig. S2