Table 2 EC50 values (μM) of synthetic ligands in yeast strains expressing human ERα, ERβ, and AR
Receptor | Strains | Ligands | |||||
|---|---|---|---|---|---|---|---|
E2* | EE2 | DES | PPT | DPN | |||
ERα | W303a | 7.66 × 10−4 | 6.34 × 10−4 | 4.20 | 18.42 | 26.04 | |
cwp1Δcwp2Δ | 8.34 × 10−5 | 4.22 × 10−5 | 3.91 | 0.92 | 3.16 | ||
ERβ | W303a | 1.89 × 10−4 | 6.59 × 10− 4 | 8.31 × 10− 4 | 13.71 | 3.54 | |
cwp1Δcwp2Δ | 5.89 × 10− 5 | 1.76 × 10− 5 | 8.50 × 10− 4 | 2.34 | 0.089 | ||
Receptor | Strains | Ligands | |||||
17α-MAS | 17β-H | 17α -MTS | TBA | STA | EE2 | ||
AR | W303a | 0.010 | 0.032 | 11.6 | 0.10 | 0.019 | 6.47 |
cwp1Δpdr5Δ | 0.027 | 0.019 | 0.078 | 0.031 | 0.022 | 2.88 | |
pdr5Δpdr10Δ | 3.10 × 10−3 | 0.016 | 0.023 | 0.75 | 0.021 | 1.88 | |