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Table 1 Level of DNA damage on V79–4 treated cell line without metabolic activation. The results are the means ±SE of at least three separate experiments (*p < 0.05 versus negative control)

From: In vitro toxicological assessment of gadolinium (III) chloride in V79–4 fibroblasts

Level of DNA damage (Arbituary unit)
 TmTD
3 h
Negative control0.31 ± 0.082.90 ± 0.63
0.25 mM GdCl30.65 ± 0.164.69 ± 1.08
0.5 mM GdCl30.44 ± 0.194.27 ± 1.24
1.0 mM GdCl31.05 ± 0.147.04 ± 0.90
 TmTD
30 min
Positive control*7.92 ± 0.49*32.42 ± 2.34
 TmTD
24 h
Negative control0.60 ± 0.075.11 ± 0.57
0.25 mM GdCl30.77 ± 0.206.49 ± 1.62
0.5 mM GdCl30.39 ± 0.033.75 ± 0.12
1.0 mM GdCl31.24 ± 0.318.85 ± 1.93
 TmTD
30 min
Positive control*6.00 ± 0.81*29.49 ± 3.38