Table 1 Level of DNA damage on V79–4 treated cell line without metabolic activation. The results are the means ±SE of at least three separate experiments (*p < 0.05 versus negative control)
From: In vitro toxicological assessment of gadolinium (III) chloride in V79–4 fibroblasts
Level of DNA damage (Arbituary unit) | ||
|---|---|---|
Tm | TD | |
3 h | ||
Negative control | 0.31 ± 0.08 | 2.90 ± 0.63 |
0.25 mM GdCl3 | 0.65 ± 0.16 | 4.69 ± 1.08 |
0.5 mM GdCl3 | 0.44 ± 0.19 | 4.27 ± 1.24 |
1.0 mM GdCl3 | 1.05 ± 0.14 | 7.04 ± 0.90 |
Tm | TD | |
30 min | ||
Positive control | *7.92 ± 0.49 | *32.42 ± 2.34 |
Tm | TD | |
24 h | ||
Negative control | 0.60 ± 0.07 | 5.11 ± 0.57 |
0.25 mM GdCl3 | 0.77 ± 0.20 | 6.49 ± 1.62 |
0.5 mM GdCl3 | 0.39 ± 0.03 | 3.75 ± 0.12 |
1.0 mM GdCl3 | 1.24 ± 0.31 | 8.85 ± 1.93 |
Tm | TD | |
30 min | ||
Positive control | *6.00 ± 0.81 | *29.49 ± 3.38 |