Table 2 Level of DNA damage on V79–4 treated cell line with metabolic activation. The results are the means ±SE of at least three separate experiments (*p < 0.05 versus negative control)
From: In vitro toxicological assessment of gadolinium (III) chloride in V79–4 fibroblasts
Level of DNA damage (Arbituary unit) | ||
|---|---|---|
Tm | TD | |
3 h | ||
Negative control | 0.42 ± 0.12 | 3.46 ± 0.72 |
Negative control + S9 | 0.47 ± 0.09 | 3.80 ± 0.66 |
0.25 mM GdCl3 | 0.61 ± 0.06 | 4.70 ± 0.30 |
0.5 mM GdCl3 | 0.98 ± 0.07 | 6.93 ± 0.34 |
1.0 mM GdCl3 | 0.54 ± 0.08 | 3.81 ± 0.63 |
Tm | TD | |
30 min | ||
Positive control | *6.87 ± 0.88 | *26.40 ± 2.14 |
Tm | TD | |
24 h | ||
Negative control | 0.42 ± 0.12 | 3.44 ± 0.45 |
Negative control + S9 | 0.66 ± 0.02 | 5.31 ± 0.50 |
0.25 mM GdCl3 | 1.15 ± 0.2 | 7.25 ± 1.25 |
0.5 mM GdCl3 | 0.97 ± 0.24 | 6.83 ± 1.46 |
1.0 mM GdCl3 | 1.32 ± 0.04 | 7.48 ± 0.47 |
Tm | TD | |
30 min | ||
Positive control | *6.87 ± 0.88 | *26.40 ± 2.14 |