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Fig. 1 | Genes and Environment

Fig. 1

From: DNA hypomethylation drives changes in MAGE-A gene expression resulting in alteration of proliferative status of cells

Fig. 1

Introduction of MAGE-A subfamily of genes and their protein products. a Schematic illustrating the focus of this paper. Melanoma Antigen Genes are divided into Type I and Type II based on their expression pattern. MAGE-A genes are considered bona fide cancer-testis antigens and are located on the X-chromosome. Type II MAGEs are ubiquitously expressed, and all members are not located on the X chromosome. b Clustal W sequence alignment shows the different percentages of sequence identity among the MAGE-A proteins. c Alignment of individual protein sequences shows that MAGE-A proteins share a MAGE homology domain (pink region) and an invariant dileucine motif (indicated by **)

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Genes and Environment

ISSN: 1880-7062

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