Radio-adaptive response and correlation of non-homologous end joining repair gene polymorphisms [XRRC5 (3R/2R/1R/0R), XRCC6(C/G) and XRCC7 (G/T)] in human peripheral blood mononuclear cells exposed to gamma radiation

Table 4 Correlation coefficient and significance levels for XRCC5 (0R/1R/2R/3R), XRCC6 (C/G) and XRCC7 (G/T) at different biological end points

Gene name	^ADNA damage at different doses		^BmRNA expression at 4 h post-irradiation with different doses		^CDNA repair at different post-irradiation time points		^DmRNA expression at various post-irradiation time points
Gene name	r	P	r	P	r	P	r	P
*XRCC5* (0R/1R/2R/3R)
0R/0R	0.971^**	0.001	−0.339	0.512	−0.939^*	0.018	−0.979^**	0.004
0R/2R	0.986^**	0.0001	0.846^*	0.034	−0.900^*	0.038	0.737^*	0.019
1R/1R	0.947^**	0.0001	0.464^**	0.001	−0.859^**	0.0001	0.366^*	0.020
1R/2R	0.967^**	0.0001	0.698^**	0.0001	−0.879^**	0.0001	0.562^**	0.001
2R/2R	0.916^**	0.0001	0.831^**	0.0001	−0.906^**	0.0001	0.871^**	0.0001
*XRCC6* (C/G)
CC	0.940^**	0.0001	0.486^**	0.0001	−0.892^**	0.0001	0.364^**	0.009
CG	0.946^**	0.0001	0.631^**	0.0001	−0.859^**	0.0001	0.433^**	0.005
GG	0.970^**	0.0001	−0.463	0.129	−0.879^**	0.001	−0.581	0.078
*XRCC7* (G/T)
GG	0.963^**	0.0001	0.086	0.650	−0.892^**	0.0001	0.199^*	0.048
GT	0.947^**	0.0001	−0.020	0.879	−0.868	0.0001	0.100	0.489
TT	0.954^**	0.0001	−0.376^*	0.041	−0.878^**	0.0001	−0.290^*	0.020

Correlation coefficient and significance levels at XRCC5 (0R/1R/2R/3R), XRCC6 (C/G) and XRCC7 (G/T) polymorphism. A. DNA damage at different dose groups, B. mRNA expression at 4 h post-irradiation, C. DNA repair at different post-irradiation time points D. mRNA expression at various post-irradiation time. (^**) and (^*) indicates sigificant correlation (P < 0.01) and (P < 0.05) respectively

ISSN: 1880-7062