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Table 6 Genotype frequency distribution, DNA damage (%T), and average relative expression in PBMCs among adaptive and non-adaptive donors exposed to priming dose (0.1 Gy) followed by a challenge dose (2.0 Gy)

From: Radio-adaptive response and correlation of non-homologous end joining repair gene polymorphisms [XRRC5 (3R/2R/1R/0R), XRCC6(C/G) and XRCC7 (G/T)] in human peripheral blood mononuclear cells exposed to gamma radiation

Genotypes Adaptive individuals (N = 16) Non-adaptive individuals (N = 4)
(N, Frequency %) Average %T ± SD in primed cells Average relative expression ± SD in primed cells (N, Frequency %) Average %T ± SD in primed cell Average relative expression ± SD in primed cells
XRCC5 (0R/1R/2R/3R)
0R/1R 0 (0.00%) 0.00 ± 0.00 0.00 ± 0.00 1(25.00%) 9.36 ± 0.00 0.92 ± 0.00
0R/2R 0 (0.00%) 0.00 ± 0.00 0.00 ± 0.00 1(25.00%) 8.01 ± 0.00 1.14 ± 0.00
1R/1R 7 (43.75%) 7.15 ± 1.67 1.09 ± 0.31 1(25.00%) 8.98 ± 0.00 1.12 ± 0.00
1R/2R 5 (31.25%) 6.44 ± 0.32 1.04 ± 0.13 1(25.00%) 9.55 ± 0.00 1.04 ± 0.00
2R/2R 4 (25.00%) 7.41 ± 1.23 1.27 ± 0.28 0 (0.00%) 0.00 ± 0.00 0.00 ± 0.00
XRCC6 (C/G)
CC 7 (43.75%) 7.27 ± 0.96 1.24 ± 0.40 3 (75.0%) 7.71 ± 1.45 1.14 ± 0.22
CG 7 (43.75%) 6.90 ± 1.69 1.22 ± 0.26 1 (25.0%) 9.55 ± 0.00 0.95 ± 0.00
GG 2 (12.50%) 6.42 ± 0.01 1.10 ± 0.04 0 (0.0%) 0.00 ± 0.00 0.00 ± 0.00
XRCC7 (G/T)
GG 4 (25.00%) 6.35 ± 0.43 1.16 ± 0.11 1 (25.0%) 9.55 ± 0.00 0.95 ± 0.00
GT 10 (62.50%) 7.08 ± 1.41 1.27 ± 0.37 1 (25.0%) 8.01 ± 0.00 1.35 ± 0.00
TT 2 (12.50%) 7.92 ± 1.42 1.05 ± 0.14 2 (50.0%) 7.56 ± 2.02 1.04 ± 0.17
  1. “N” indicates number of donors showing a particular genotype, SD Standard Deviation