Table 6 Genotype frequency distribution, DNA damage (%T), and average relative expression in PBMCs among adaptive and non-adaptive donors exposed to priming dose (0.1 Gy) followed by a challenge dose (2.0 Gy)
Genotypes | Adaptive individuals (N = 16) | Non-adaptive individuals (N = 4) | ||||
|---|---|---|---|---|---|---|
(N, Frequency %) | Average %T ± SD in primed cells | Average relative expression ± SD in primed cells | (N, Frequency %) | Average %T ± SD in primed cell | Average relative expression ± SD in primed cells | |
XRCC5 (0R/1R/2R/3R) | ||||||
0R/1R | 0 (0.00%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 1(25.00%) | 9.36 ± 0.00 | 0.92 ± 0.00 |
0R/2R | 0 (0.00%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 1(25.00%) | 8.01 ± 0.00 | 1.14 ± 0.00 |
1R/1R | 7 (43.75%) | 7.15 ± 1.67 | 1.09 ± 0.31 | 1(25.00%) | 8.98 ± 0.00 | 1.12 ± 0.00 |
1R/2R | 5 (31.25%) | 6.44 ± 0.32 | 1.04 ± 0.13 | 1(25.00%) | 9.55 ± 0.00 | 1.04 ± 0.00 |
2R/2R | 4 (25.00%) | 7.41 ± 1.23 | 1.27 ± 0.28 | 0 (0.00%) | 0.00 ± 0.00 | 0.00 ± 0.00 |
XRCC6 (C/G) | ||||||
CC | 7 (43.75%) | 7.27 ± 0.96 | 1.24 ± 0.40 | 3 (75.0%) | 7.71 ± 1.45 | 1.14 ± 0.22 |
CG | 7 (43.75%) | 6.90 ± 1.69 | 1.22 ± 0.26 | 1 (25.0%) | 9.55 ± 0.00 | 0.95 ± 0.00 |
GG | 2 (12.50%) | 6.42 ± 0.01 | 1.10 ± 0.04 | 0 (0.0%) | 0.00 ± 0.00 | 0.00 ± 0.00 |
XRCC7 (G/T) | ||||||
GG | 4 (25.00%) | 6.35 ± 0.43 | 1.16 ± 0.11 | 1 (25.0%) | 9.55 ± 0.00 | 0.95 ± 0.00 |
GT | 10 (62.50%) | 7.08 ± 1.41 | 1.27 ± 0.37 | 1 (25.0%) | 8.01 ± 0.00 | 1.35 ± 0.00 |
TT | 2 (12.50%) | 7.92 ± 1.42 | 1.05 ± 0.14 | 2 (50.0%) | 7.56 ± 2.02 | 1.04 ± 0.17 |