Radio-adaptive response and correlation of non-homologous end joining repair gene polymorphisms [XRRC5 (3R/2R/1R/0R), XRCC6(C/G) and XRCC7 (G/T)] in human peripheral blood mononuclear cells exposed to gamma radiation

Table 6 Genotype frequency distribution, DNA damage (%T), and average relative expression in PBMCs among adaptive and non-adaptive donors exposed to priming dose (0.1 Gy) followed by a challenge dose (2.0 Gy)

Genotypes	Adaptive individuals (N = 16)			Non-adaptive individuals (N = 4)
Genotypes	(N, Frequency %)	Average %T ± SD in primed cells	Average relative expression ± SD in primed cells	(N, Frequency %)	Average %T ± SD in primed cell	Average relative expression ± SD in primed cells
*XRCC5* (0R/1R/2R/3R)
0R/1R	0 (0.00%)	0.00 ± 0.00	0.00 ± 0.00	1(25.00%)	9.36 ± 0.00	0.92 ± 0.00
0R/2R	0 (0.00%)	0.00 ± 0.00	0.00 ± 0.00	1(25.00%)	8.01 ± 0.00	1.14 ± 0.00
1R/1R	7 (43.75%)	7.15 ± 1.67	1.09 ± 0.31	1(25.00%)	8.98 ± 0.00	1.12 ± 0.00
1R/2R	5 (31.25%)	6.44 ± 0.32	1.04 ± 0.13	1(25.00%)	9.55 ± 0.00	1.04 ± 0.00
2R/2R	4 (25.00%)	7.41 ± 1.23	1.27 ± 0.28	0 (0.00%)	0.00 ± 0.00	0.00 ± 0.00
*XRCC6* (C/G)
CC	7 (43.75%)	7.27 ± 0.96	1.24 ± 0.40	3 (75.0%)	7.71 ± 1.45	1.14 ± 0.22
CG	7 (43.75%)	6.90 ± 1.69	1.22 ± 0.26	1 (25.0%)	9.55 ± 0.00	0.95 ± 0.00
GG	2 (12.50%)	6.42 ± 0.01	1.10 ± 0.04	0 (0.0%)	0.00 ± 0.00	0.00 ± 0.00
*XRCC7* (G/T)
GG	4 (25.00%)	6.35 ± 0.43	1.16 ± 0.11	1 (25.0%)	9.55 ± 0.00	0.95 ± 0.00
GT	10 (62.50%)	7.08 ± 1.41	1.27 ± 0.37	1 (25.0%)	8.01 ± 0.00	1.35 ± 0.00
TT	2 (12.50%)	7.92 ± 1.42	1.05 ± 0.14	2 (50.0%)	7.56 ± 2.02	1.04 ± 0.17

“N” indicates number of donors showing a particular genotype, SD Standard Deviation

ISSN: 1880-7062