Table 4 Enrichment analysis of 168 specific DEPs in the tretment of 4-nitroanthranilic acid (24-h 800 μg/mL group)

 INTERPRO

IPR016239:Ribosomal protein S6 kinase II

4

5.74E-06

 GOTERM_MF_DIRECT

GO:0005515 ~ protein binding

88

1.74E-05

 PIR_SUPERFAMILY

PIRSF000606:ribosomal protein S6 kinase II

4

3.22E-05

 GOTERM_MF_DIRECT

GO:0016301 ~ kinase activity

10

6.80E-05

 GOTERM_CC_DIRECT

GO:0005739 ~ mitochondrion

22

2.16E-04

 SMART

SM00133:S_TK_X

5

3.29E-04

 GOTERM_CC_DIRECT

GO:0005829 ~ cytosol

39

4.31E-04

 INTERPRO

IPR000961:AGC-kinase, C-terminal

5

5.33E-04

 GOTERM_CC_DIRECT

GO:0005654 ~ nucleoplasm

34

6.58E-04

 INTERPRO

IPR017892:Protein kinase, C-terminal

4

0.0010359705

 GOTERM_CC_DIRECT

GO:0005759 ~ mitochondrial matrix

9

0.0017034795

 GOTERM_BP_DIRECT

GO:0034244 ~ negative regulation of transcription elongation from RNA polymerase II promoter

3

0.0027144316

 GOTERM_CC_DIRECT

GO:0005737 ~ cytoplasm

51

0.0027796207

 GOTERM_BP_DIRECT

GO:0008631 ~ intrinsic apoptotic signaling pathway in response to oxidative stress

3

0.0050854061

 GOTERM_CC_DIRECT

GO:0005840 ~ ribosome

6

0.0053822808

 GOTERM_MF_DIRECT

GO:0044822 ~ poly(A) RNA binding

17

0.0078806589

 GOTERM_CC_DIRECT

GO:0005743 ~ mitochondrial inner membrane

9

0.0101302596

 GOTERM_CC_DIRECT

GO:0005793 ~ endoplasmic reticulum-Golgi intermediate compartment

4

0.0109324145

 GOTERM_BP_DIRECT

GO:0001701 ~ in utero embryonic development

6

0.011424021

 GOTERM_CC_DIRECT

GO:0016020 ~ membrane

25

0.0115217146

 GOTERM_MF_DIRECT

GO:0005524 ~ ATP binding

20

0.0117814813

 GOTERM_BP_DIRECT

GO:0010628 ~ positive regulation of gene expression

7

0.0117937932

 GOTERM_BP_DIRECT

GO:0051301 ~ cell division

8

0.0134335953

 GOTERM_BP_DIRECT

GO:0043555 ~ regulation of translation in response to stress

2

0.0143601269

 INTERPRO

IPR027417:P-loop containing nucleoside triphosphate hydrolase

13

0.0146424367

 GOTERM_MF_DIRECT

GO:0004672 ~ protein kinase activity

8

0.0161283188

 GOTERM_MF_DIRECT

GO:0000287 ~ magnesium ion binding

6

0.0168341212

 GOTERM_BP_DIRECT

GO:2000145 ~ regulation of cell motility

3

0.0172254639

 INTERPRO

IPR018199:Ribosomal protein S4e, N-terminal, conserved site

2

0.0199116243

 INTERPRO

IPR013845:Ribosomal protein S4e, central region

2

0.0199116243

 INTERPRO

IPR013843:Ribosomal protein S4e, N-terminal

2

0.0199116243

 INTERPRO

IPR000876:Ribosomal protein S4e

2

0.0199116243

 INTERPRO

IPR000633:Vinculin, conserved site

2

0.0199116243

 GOTERM_BP_DIRECT

GO:0006368 ~ transcription elongation from RNA polymerase II promoter

4

0.0242278191

 INTERPRO

IPR001033:Alpha-catenin

2

0.0264610401

 INTERPRO

IPR023321:PINIT domain

2

0.0264610401

 GOTERM_CC_DIRECT

GO:0032021 ~ NELF complex

2

0.0267274499

 GOTERM_MF_DIRECT

GO:0048487 ~ beta-tubulin binding

3

0.0282329504

 GOTERM_BP_DIRECT

GO:0019673 ~ GDP-mannose metabolic process

2

0.0285157205

 SMART

SM00220:S_TKc

7

0.0318734045

 GOTERM_BP_DIRECT

GO:0030521 ~ androgen receptor signaling pathway

3

0.0351748989

 GOTERM_MF_DIRECT

GO:0061665 ~ SUMO ligase activity

2

0.0359086364

 PIR_SUPERFAMILY

PIRSF002116:ribosomal protein S4a/S4e

2

0.0367953139

 INTERPRO

IPR002942:RNA-binding S4 domain

2

0.03942991

 GOTERM_CC_DIRECT

GO:0022627 ~ cytosolic small ribosomal subunit

3

0.0416602582

 GOTERM_BP_DIRECT

GO:0043620 ~ regulation of DNA-templated transcription in response to stress

2

0.0424696701

 GOTERM_BP_DIRECT

GO:0046939 ~ nucleotide phosphorylation

2

0.0424696701

 INTERPRO

IPR017441:Protein kinase, ATP binding site

7

0.0427994892

 GOTERM_BP_DIRECT

GO:0007507 ~ heart development

5

0.0434212707

 GOTERM_MF_DIRECT

GO:0016887 ~ ATPase activity

5

0.0449232427

 INTERPRO

IPR000719:Protein kinase, catalytic domain

8

0.0450805987

 INTERPRO

IPR006077:Vinculin/alpha-catenin

2

0.0458499332

 INTERPRO

IPR004181:Zinc finger, MIZ-type

2

0.0458499332

 GOTERM_MF_DIRECT

GO:0003723 ~ RNA binding

9

0.0467405365

 GOTERM_CC_DIRECT

GO:0005730 ~ nucleolus

13

5.68E-07

 GOTERM_MF_DIRECT

GO:0044822 ~ poly(A) RNA binding

15

7.76E-07

 GOTERM_BP_DIRECT

GO:0006364 ~ rRNA processing

7

1.24E-05

 GOTERM_CC_DIRECT

GO:0005634 ~ nucleus

27

4.81E-05

 GOTERM_CC_DIRECT

GO:0032040 ~ small-subunit processome

4

8.14E-05

 GOTERM_CC_DIRECT

GO:0005737 ~ cytoplasm

25

2.75E-04

 GOTERM_CC_DIRECT

GO:0005654 ~ nucleoplasm

17

4.87E-04

 GOTERM_BP_DIRECT

GO:0000462 ~ maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

3

0.0027542237

 GOTERM_MF_DIRECT

GO:0005515 ~ protein binding

34

0.0028754728

 INTERPRO

IPR006709:Small-subunit processome, Utp14

2

0.0049511535

 GOTERM_CC_DIRECT

GO:0005815 ~ microtubule organizing center

4

0.0059735276

 GOTERM_BP_DIRECT

GO:0051301 ~ cell division

5

0.0102371094

 GOTERM_CC_DIRECT

GO:0034388 ~ Pwp2p-containing subcomplex of 90S preribosome

2

0.0167816086

 GOTERM_BP_DIRECT

GO:0002726 ~ positive regulation of T cell cytokine production

2

0.0241562593

 GOTERM_CC_DIRECT

GO:0070062 ~ extracellular exosome

13

0.0308651552

 GOTERM_BP_DIRECT

GO:0030490 ~ maturation of SSU-rRNA

2

0.0336585264

 INTERPRO

IPR017986:WD40-repeat-containing domain

4

0.0400340949

 GOTERM_BP_DIRECT

GO:0022904 ~ respiratory electron transport chain

2

0.0477428897

 INTERPRO

IPR015943:WD40/YVTN repeat-like-containing domain

4

0.0486054435