Table 3 The association between 4 SNPs within VDR gene and RCC risk
SNP | Genotypes and Alleles | Frequencies N (%) | OR (95 %CI) a | HWE test for controls | |
|---|---|---|---|---|---|
Controls (n = 735) | Cases (n = 366) | ||||
rs2228570 (FokI) | 0.997 | ||||
CC | 432 (58.8) | 191 (52.2) | 1.00 (ref) | ||
CT | 263 (35.8) | 143 (39.1) | 1.32 (0.91–1.83) | ||
TT | 40 (5.4) | 32 (8.7) | 1.55 (0.72–2.42) | ||
CT + TT | 303 (41.2) | 175 (47.8) | 1.39 (0.86–1.93) | ||
Allele, T (%) | 343 (23.3) | 207 (28.3) | |||
rs7975232 (ApaI) | 0.289 | ||||
CC | 475 (64.6) | 182 (49.7) | 1.00 (ref) | ||
CA | 226 (30.7) | 149 (40.7) | 1.63 (1.21–2.04) | ||
AA | 34 (4.6) | 35 (9.6) | 2.02 (1.47–2.62) | ||
CA + AA | 260 (35.4) | 184 (50.3) | 1.75 (1.26–2.28) | ||
Allele, A (%) | 294 (20.0) | 219 (29.9) | |||
rs731236 (TaqI) | 0.735 | ||||
TT | 460 (62.6) | 200 (54.6) | 1.00 (ref) | ||
TC | 241 (32.8) | 139 (38.0) | 1.24 (0.92–1.65) | ||
CC | 34 (4.6) | 27 (7.4) | 1.31 (0.81–1.86) | ||
TC + CC | 275 (37.4) | 166 (45.4) | 1.26 (0.89–1.69) | ||
Allele, C (%) | 309 (21.0) | 193 (26.4) | |||
rs1544410 (BsmI) | 0.655 | ||||
GG | 466 (63.4) | 211 (57.7) | 1.00 (ref) | ||
GA | 236 (32.1) | 130 (35.5) | 1.31 (0.87–1.79) | ||
AA | 33 (4.5) | 25 (7.8) | 1.45 (0.78–2.15) | ||
GA + AA | 269 (36.6) | 155 (42.3) | 1.34 (0.84–1.87) | ||
Allele, A (%) | 302 (20.5) | 180 (24.6) | |||