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Table 4 GMDR analysis on the best gene–environment interaction models

From: Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk

Locus no.

Best combination

Cross-validation consistency

Testing accuracy

p-values

Gene- alcohol drinking interactionsa

2

1, 5

9/10

0.572

0.055

3

1, 2, 5

7/10

0.540

0.172

4

1, 2, 4, 5

6/10

0.423

0.377

5

1, 2, 4, 3, 5

6/10

0.496

0.426

Gene- smoking interactionsb

2

1, 6

10/10

0.607

0.001

3

1, 3, 6

8/10

0.540

0.172

4

1, 3, 2, 6

7/10

0.487

0.623

5

1, 3, 2, 4, 6

6/10

0.478

0.989

  1. a Adjusted for gender, age, hypertension, diabetes, smoking and BMI
  2. bAdjusted for gender, age, hypertension, diabetes, drinking and BMI
  3. rs7975232, rs2228570, rs1544410, rs731236, current alcohol drinking and current smoking were symbolized as 1–6, respectively
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Genes and Environment

ISSN: 1880-7062

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