Table 3 Genotype distribution and allele frequencies of four SNPs in case and control group
SNPs | Genotypes and alleles | Frequencies N (%) | OR (95 %CI) * | P-values | |
|---|---|---|---|---|---|
Control (n = 720) | Case (n = 358) | ||||
rs12255372 | |||||
GG | 419 (58.2) | 191 (53.4) | Ref | ||
GT | 260 (36.1) | 140 (39.1) | 1.23 (0.90–1.66) | ||
TT | 41 (5.7) | 27 (7.5) | 1.38 (0.81–1.97) | ||
G | 1098 (76.02 | 522 (72.9) | Ref | ||
T | 342 (23.8) | 194 (27.1) | 1.26 (0.88–1.69) | ||
HWE test for controls | 0.936 | ||||
rs7903146 | |||||
CC | 469 (65.1) | 185 (51.7) | Ref | ||
CT | 218 (30.3) | 139 (38.8) | 1.59 (1.21–1.99) | ||
TT | 33 (4.6) | 34 (9.5) | 1.82 (1.27–2.43) | ||
C | 1156 (80.3) | 509 (71.1) | Ref | ||
T | 284 (19.7) | 207 (28.9) | 1.64 (1.24–2.06) | ||
HWE test for controls | 0.240 | ||||
rs11196205 | |||||
GG | 427 (59.3) | 191 (53.4) | Ref | ||
GT | 256 (35.6) | 139 (38.8) | 1.28 (0.83–1.76) | ||
TT | 37 (5.1) | 28 (7.8) | 1.42 (0.78–2.09) | ||
G | 1110 (77.1) | 521 (72.8) | Ref | ||
T | 330 (22.9) | 195 (27.2) | 1.30 (0.81–1.87) | ||
HWE test for controls | 0.864 | ||||
rs290487 | |||||
TT | 473 (65.7) | 215 (60.1) | Ref | ||
TC | 219 (30.4) | 123 (34.4) | 1.30 (0.96–1.67) | ||
CC | 28 (3.9) | 20 (5.6) | 1.46 (0.90–2.05) | ||
T | 1165 (80.9) | 553 (77.2) | Ref | ||
C | 275 (19.1) | 163 (22.8) | 1.33 (0.94–1.72) | ||
HWE test for controls | 0.674 | ||||