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Table 4 GMDR analysis on the best SNP–SNP and gene- current smoking interaction models

From: Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population

Locus no.

Best combination

Cross-validation consistency

Testing balanced accuracy

p-values*

SNP- SNP interactions *

   

2

(1, 3)

8/10

0.5451

0.3770

3

(1, 3, 2)

6/10

0.5577

0.3240

4

(1, 3, 2, 4)

7/10

0.4960

0.6241

Gene- current smoking interactions **

   

2

(1, 5)

9/10

0.5985

0.0107

3

(1, 5, 3)

7/10

0.5622

0.3770

4

(1, 5, 3, 2)

6/10

0.5577

0.1719

5

(1, 5, 3, 2, 4)

7/10

0.5212

0.4258

  1. *Adjusted for gender, age, BMI, smoking, alcohol drinking, FPG, duration of diabetes and hypertension
  2. **Adjusted for gender, age, BMI, alcohol drinking, FPG, duration of diabetes and hypertension
  3. rs7903146, rs12255372, rs290487, rs11196205 and current smoking were symbolized as 1–5, respectively
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