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Table 2 The Spi mutation spectra in the liver of BaP and ENU-treated homozygous gpt delta rats

From: New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

  0 mg/kg/day (28 + 3d) BaP 125 mg/kg/day (28 + 3d) ENU 50 mg/kg/day (5 + 26d)
  male female male female male female
No. (%) MF (x10− 6) No. (%) MF (x10− 6) No. (%) MF (x10− 6) No. (%) MF (x10− 6) No. (%) MF (x10− 6) No. (%) MF (x10− 6)
One bp deletion 34 85.0 4.6 34 77.3 4.2 20 71.4 13.0 18 81.8 14.2 11 64.7 4.7 13 76.5 3.9
 at G:C 19 47.5 2.6 12 27.3 1.5 14 50.0 9.1 15 68.2 11.9 7 41.2 3.0 5 29.4 1.5
 at A:T 15 37.5 2.0 22 50.0 2.7 6 21.4 3.9 3 13.6 2.4 4 23.5 1.7 8 47.1 2.4
> 2 bps deletion 5 12.5 0.7 7 15.9 0.9 4 14.3 2.6 1 4.5 0.8 2 11.8 0.8 3 17.6 0.9
Base substitution 0 0.0 0.0 1 2.3 0.1 3 10.7 2.0 2 9.1 1.6 3 17.6 1.3 0 0.0 0.0
Insertion 0 0.0 0.0 0 0.0 0.0 1 3.6 0.7 0 0.0 0.0 0 0.0 0.0 0 0.0 0.0
Complex 1 2.5 0.1 2 4.5 0.2 0 0.0 0.0 1 4.5 0.8 1 5.9 0.4 1 5.9 0.3
Total 40 100.0 5.5 44 100.0 5.4 28 100.0 18.3 22 100.0 17.4 17 100.0 7.2 17 100.0 5.1