Table 2 The Spi− mutation spectra in the liver of BaP and ENU-treated homozygous gpt delta rats
0 mg/kg/day (28 + 3d) | BaP 125 mg/kg/day (28 + 3d) | ENU 50 mg/kg/day (5 + 26d) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
male | female | male | female | male | female | |||||||||||||
No. | (%) | MF (x10− 6) | No. | (%) | MF (x10− 6) | No. | (%) | MF (x10− 6) | No. | (%) | MF (x10− 6) | No. | (%) | MF (x10− 6) | No. | (%) | MF (x10− 6) | |
One bp deletion | 34 | 85.0 | 4.6 | 34 | 77.3 | 4.2 | 20 | 71.4 | 13.0 | 18 | 81.8 | 14.2 | 11 | 64.7 | 4.7 | 13 | 76.5 | 3.9 |
at G:C | 19 | 47.5 | 2.6 | 12 | 27.3 | 1.5 | 14 | 50.0 | 9.1 | 15 | 68.2 | 11.9 | 7 | 41.2 | 3.0 | 5 | 29.4 | 1.5 |
at A:T | 15 | 37.5 | 2.0 | 22 | 50.0 | 2.7 | 6 | 21.4 | 3.9 | 3 | 13.6 | 2.4 | 4 | 23.5 | 1.7 | 8 | 47.1 | 2.4 |
> 2 bps deletion | 5 | 12.5 | 0.7 | 7 | 15.9 | 0.9 | 4 | 14.3 | 2.6 | 1 | 4.5 | 0.8 | 2 | 11.8 | 0.8 | 3 | 17.6 | 0.9 |
Base substitution | 0 | 0.0 | 0.0 | 1 | 2.3 | 0.1 | 3 | 10.7 | 2.0 | 2 | 9.1 | 1.6 | 3 | 17.6 | 1.3 | 0 | 0.0 | 0.0 |
Insertion | 0 | 0.0 | 0.0 | 0 | 0.0 | 0.0 | 1 | 3.6 | 0.7 | 0 | 0.0 | 0.0 | 0 | 0.0 | 0.0 | 0 | 0.0 | 0.0 |
Complex | 1 | 2.5 | 0.1 | 2 | 4.5 | 0.2 | 0 | 0.0 | 0.0 | 1 | 4.5 | 0.8 | 1 | 5.9 | 0.4 | 1 | 5.9 | 0.3 |
Total | 40 | 100.0 | 5.5 | 44 | 100.0 | 5.4 | 28 | 100.0 | 18.3 | 22 | 100.0 | 17.4 | 17 | 100.0 | 7.2 | 17 | 100.0 | 5.1 |