Skip to main content

Table 2 Summary of mutations induced in sequences of three to five adenine nucleotides (A-runs) in the gpt gene in the small intestine of Msh2-KO mice

From: Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice

Nucleotide position of A-run within the gpt gene Original sequence Mutated sequence Number of mutants and independent mutations
Vehicle control KBrO3 administered
7–12 AAAAA AAAAd 3 (1) 6 (3)
88–90 AAA AAd 1 (1) 2 (1)
173–175 TTT TTC 0 2 (1)
179–181 TTT TTC 0 1 (1)
TTTT 0 1 (1)
214–216 AAA AAAA 0 1 (1)
223–225 AAA AAd 1 (1) 2 (2)
315–318 AAAA AAAd 4 (1) 3 (3)
325–327 TTT TTd 0 1 (1)
342–345 AAAA AAAd 2 (1) 5 (2)
AAAAAA 0 2 (1)
AAAAA 0 2 (2)
AAAC 1 (1) 2 (2)
Number of mutants in A-runs 12(6) 30 * (21 *)
Total number of mutants in gpt 107 (66) 149 (97)
  1. * P < 0.05, significantly different compared with vehicle control by Fisher’s exact test.
  2. Numbers in parentheses indicate the numbers of independent mutations.
  3. “d” indicates base deletion.