Table 2 Summary of mutations induced in sequences of three to five adenine nucleotides (A-runs) in the gpt gene in the small intestine of Msh2-KO mice
From: Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
Nucleotide position of A-run within the gpt gene | Original sequence | Mutated sequence | Number of mutants and independent mutations | |
|---|---|---|---|---|
Vehicle control | KBrO3 administered | |||
7–12 | AAAAA | AAAAd | 3 (1) | 6 (3) |
88–90 | AAA | AAd | 1 (1) | 2 (1) |
173–175 | TTT | TTC | 0 | 2 (1) |
179–181 | TTT | TTC | 0 | 1 (1) |
TTTT | 0 | 1 (1) | ||
214–216 | AAA | AAAA | 0 | 1 (1) |
223–225 | AAA | AAd | 1 (1) | 2 (2) |
315–318 | AAAA | AAAd | 4 (1) | 3 (3) |
325–327 | TTT | TTd | 0 | 1 (1) |
342–345 | AAAA | AAAd | 2 (1) | 5 (2) |
AAAAAA | 0 | 2 (1) | ||
AAAAA | 0 | 2 (2) | ||
AAAC | 1 (1) | 2 (2) | ||
Number of mutants in A-runs | 12(6) | 30 * (21 *) | ||
Total number of mutants in gpt | 107 (66) | 149 (97) | ||