Fig. 12
From: Metabolism and biomarkers of heterocyclic aromatic amines in humans
a Mechanism of acid-labile PhIP sulfinamide adduct formation at SA-Cys34. b Kinetics of formation and removal of this acid-labile PhIP-SA adduct in plasma of subjects on a cooked meat diet containing known quantities of PhIP. Box and whiskers plot showing the distribution of PhIP-SA measured over the entire study, separately for Group 3 (N = 13) and Group 4 (N = 7) ingested PhIP during the meat-feeding phase (days 22–49). Adapted with permission from [252]