Metabolism and biomarkers of heterocyclic aromatic amines in humans

Genes and Environment

Table 3 HAA carcinogenicity in animals^a

HAA	Animal	Strain	Dose (mg/kg)	Exposure peroid (weeks)	Target organ
PhIP	Rat	F344	400	52	Colon, Mammary gland, Prostate, Lymphoid tissue
	Rat	Big Blue	400	60	Colon mucosa, Mammary gland
	Mouse	CDF1	400	82	Lymphoid tissue
		C57BL/6 N	300	70-95	Small intestine, Lymphoid tissue
		Big Blue	300		Colon mucosa
MeIOx	Rat	F344	400	61	Liver, Zymbal gland, Clitoral gland, Skin
MeIOx	Mouse	CDF1	600	84	Liver, lung, Hematopoietic system
MeIQ	Rat	F344	300	40	Colon, Zymbal gland, Skin, Oral cavity, Mammary gland
	Mouse	CDF1	400	91	Liver, Forestomach
		C57BL/6	300		Liver, Colon
		Big Blue	300	60	Colon mucosa
IQ	Rat	F344	300	55 - 72	Liver, Small intestine, Colon, Zymbal gland, Clitoral gland, Skin
	Mouse	CDF1	300	96	Liver, Forestomach, lung
	Monkey	cynomolgus	10 - 20	172 - 240	Liver
MeAαC	Rat	F344	100	100	Liver
MeAαC	Mouse	CDF1	800	84	Liver, Blood vessels
AαC	Mouse	CDF1	800	98	Liver, Blood vessels
Glu-P-1	Rat	F344	500	64	Liver, Small intestine, Colon, Zymbal gland, Clitoral gland
Glu-P-1	Mouse	CDF1	500	57	Liver, Blood vessels
Glu-P-2	Rat	F344	500	104	Liver, Small intestine, Colon, Zymbal gland, Clitoral gland
Glu-P-2	Mouse	CDF1	500	84	Liver, Blood vessels
Trp-P-1	Rat	F344	150	52	Liver
Trp-P-1	Mouse	CDF1	200	89	Liver
Trp-P-2	Rat	F3444	100	112	Liver, Bladder
Trp-P-2	Mouse	CDF1	200	89	Liver

ISSN: 1880-7062