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Table 3 HAA carcinogenicity in animalsa

From: Metabolism and biomarkers of heterocyclic aromatic amines in humans

HAA Animal Strain Dose (mg/kg) Exposure peroid
(weeks)
Target organ
PhIP Rat F344 400 52 Colon, Mammary gland, Prostate, Lymphoid tissue
Big Blue 400 60 Colon mucosa, Mammary gland
Mouse CDF1 400 82 Lymphoid tissue
C57BL/6 N 300 70-95 Small intestine, Lymphoid tissue
Big Blue 300   Colon mucosa
MeIOx Rat F344 400 61 Liver, Zymbal gland, Clitoral gland, Skin
Mouse CDF1 600 84 Liver, lung, Hematopoietic system
MeIQ Rat F344 300 40 Colon, Zymbal gland, Skin, Oral cavity, Mammary gland
Mouse CDF1 400 91 Liver, Forestomach
C57BL/6 300   Liver, Colon
Big Blue 300 60 Colon mucosa
IQ Rat F344 300 55 - 72 Liver, Small intestine, Colon, Zymbal gland, Clitoral gland, Skin
Mouse CDF1 300 96 Liver, Forestomach, lung
Monkey cynomolgus 10 - 20 172 - 240 Liver
MeAαC Rat F344 100 100 Liver
Mouse CDF1 800 84 Liver, Blood vessels
AαC Mouse CDF1 800 98 Liver, Blood vessels
Glu-P-1 Rat F344 500 64 Liver, Small intestine, Colon, Zymbal gland, Clitoral gland
Mouse CDF1 500 57 Liver, Blood vessels
Glu-P-2 Rat F344 500 104 Liver, Small intestine, Colon, Zymbal gland, Clitoral gland
Mouse CDF1 500 84 Liver, Blood vessels
Trp-P-1 Rat F344 150 52 Liver
Mouse CDF1 200 89 Liver
Trp-P-2 Rat F3444 100 112 Liver, Bladder
Mouse CDF1 200 89 Liver
  1. areproduced with permission from [2]