MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Dong, Xiaobo; Wang, Jun; Wang, Gesheng; Wang, Jiayue; Wang, Lei; Du, Yong

doi:10.1186/s41021-021-00208-z

Genes and Environment

Table 1 Studies and data included in this meta-analysis

From: MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Author	Year	Country	Type	Population	Source of control	Sample size		case					control					NOS score	HWE
Author	Year	Country	Type	Population	Source of control	case	control	CC	CA	AA	C	A	CC	CA	AA	C	A	NOS score	HWE
Akar et al	2001	Turkey	IS	Children	NR	46	68	13	27	6	53	39	31	32	5	94	42	7	0.399
Lin et al	2004	China	IS	Adults	HB	68	50	50	16	2	116	20	35	15	0	85	15	8	0.212
Linnebank et al	2005	Germany	IS	Adults	PB	159	159	80	65	14	225	93	73	64	22	210	108	8	0.196
Sun et al	2005	China	IS	Adults	NR	97	94	55	40	2	150	44	60	31	3	151	37	8	0.676
Komitopoulou et al	2006	Greece	IS	Children	HB	89	103	35	45	9	115	63	50	40	13	140	66	7	0.272
Sazci et al	2006	Turkey	IS	Adults	NR	92	259	36	37	19	109	75	130	108	21	368	150	8	0.828
Sazci et al	2006	Turkey	HS	Adults	NR	28	259	16	9	3	41	15	130	108	21	368	150	8	0.828
Dikmen et al	2006	Turkey	IS	Adults	NR	154	55	59	79	16	197	111	19	33	3	71	39	7	0.021
Dikmen et al	2006	Turkey	HS	Adults	NR	49	55	19	23	7	61	37	19	33	3	71	39	7	0.021
Zhang et al	2007	China	IS	Adults	NR	100	100	56	40	4	152	48	64	33	3	161	39	8	0.609
Sirachainan et al	2008	Thailand	IS	Children	HB	44	164	22	19	3	63	25	82	69	13	233	95	6	0.774
Biswas et al	2009	India	IS	Children	NR	58	58	38	14	6	90	26	50	7	1	107	9	8	0.232
Morita et al	2009	America	IS	Children	PB	23	90	17	6	0	40	6	41	36	13	118	62	6	0.278
Sawula et al	2009	Poland	IS	Adults	HB	128	59	53	57	18	163	93	26	22	11	74	44	7	0.119
Almawi et al	2009	Bahrain	MIXED	Adults	HB	118	120	50	38	30	138	98	54	60	6	168	72	6	0.037
Biswas et al	2009	India	IS	Adults	HB	120	120	80	31	9	191	49	90	24	6	204	36	7	0.018
Chen et al	2010	China	IS	Adults	HB	470	495	354	109	7	817	123	387	105	3	879	111	7	0.146
Han et al	2010	Korea	IS	Adults	HB	264	234	179	80	5	438	90	182	51	1	415	53	8	0.193
Giusti et al	2010	Italy	IS	Adults	HB	501	1211	248	197	56	693	309	572	529	110	1673	749	7	0.434
Hultdin et al	2011	Sweden	IS	Adults	NR	314	767	135	142	37	412	216	328	346	93	1002	532	7	0.905
Hultdin et al	2011	Sweden	HS	Adults	NR	59	767	29	29	1	87	31	328	346	93	1002	532	7	0.905
Arsene et al	2011	Bahrain	IS	Adults	HB	67	60	30	28	9	88	46	25	27	8	77	43	7	0.868
Zhang et al	2012	China	IS	Adults	HB	67	71	38	29	0	105	29	57	14	0	128	14	7	0.357
Xu et al	2012	China	MIXED	Adults	HB	70	50	7	41	22	55	85	12	30	8	54	46	8	0.142
Zhang et al	2012	China	IS	Adults	HB	40	40	27	12	1	66	14	33	7	0	73	7	8	0.544
Fekih-Mrissa et al	2013	Tunisia	IS	Adults	HB	84	100	58	15	11	131	37	93	7	0	193	7	7	0.717
Gelfand et al	2013	America	IS	Children	PB	13	84	4	7	2	15	11	39	41	4	119	49	8	0.097
Zhou et al	2014	China	IS	Adults	HB	542	654	333	174	35	840	244	448	182	24	1078	230	8	0.308
Balcerzyk et al	2015	Poland	IS	Children	NR	88	111	51	30	7	132	44	53	47	11	153	69	7	0.902
Lv et al	2015	China	IS	Adults	NR	199	241	31	97	71	159	239	71	110	60	252	230	8	0.186
Wei et al	2015	Malaysia	IS	Adults	NR	297	297	184	95	18	463	131	186	104	7	476	118	6	0.085
Kamberi et al	2016	Albania	IS	Adults	PB	39	102	18	20	1	56	22	54	44	4	152	52	8	0.171
Herak et al	2017	Croatia	IS	Children	HB	73	100	34	33	6	101	45	52	39	9	143	57	8	0.667
Wang et al	2017	China	MIXED	Adults	NR	225	169	130	85	10	345	105	99	65	5	263	75	6	0.139
Zhao et al	2017	China	IS	Adults	HB	130	100	98	32	0	228	32	68	32	0	168	32	8	0.057
Hu et al	2017	China	IS	Adults	HB	181	169	106	67	8	279	83	99	65	5	263	75	8	0.139
Abidi et al	2018	Morocco	HS	Adults	HB	113	323	64	46	3	174	52	186	120	17	492	154	8	0.678
Hashemi et al	2019	Iran	IS	Adults	NR	106	157	72	31	3	175	37	120	32	5	272	42	8	0.131
Xiong et al	2019	China	MIXED	Adults	HB	92	140	64	24	4	152	32	90	44	6	224	56	8	0.833
Mazdeh et al	2020	Iran	IS	Children	HB	318	400	170	121	27	461	175	235	147	18	617	183	8	0.406

Back to article page

ISSN: 1880-7062

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com