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Table 1 Studies and data included in this meta-analysis

From: MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Author Year Country Type Population Source of control Sample size case control NOS score HWE
case control CC CA AA C A CC CA AA C A
Akar et al 2001 Turkey IS Children NR 46 68 13 27 6 53 39 31 32 5 94 42 7 0.399
Lin et al 2004 China IS Adults HB 68 50 50 16 2 116 20 35 15 0 85 15 8 0.212
Linnebank et al 2005 Germany IS Adults PB 159 159 80 65 14 225 93 73 64 22 210 108 8 0.196
Sun et al 2005 China IS Adults NR 97 94 55 40 2 150 44 60 31 3 151 37 8 0.676
Komitopoulou et al 2006 Greece IS Children HB 89 103 35 45 9 115 63 50 40 13 140 66 7 0.272
Sazci et al 2006 Turkey IS Adults NR 92 259 36 37 19 109 75 130 108 21 368 150 8 0.828
Sazci et al 2006 Turkey HS Adults NR 28 259 16 9 3 41 15 130 108 21 368 150 8 0.828
Dikmen et al 2006 Turkey IS Adults NR 154 55 59 79 16 197 111 19 33 3 71 39 7 0.021
Dikmen et al 2006 Turkey HS Adults NR 49 55 19 23 7 61 37 19 33 3 71 39 7 0.021
Zhang et al 2007 China IS Adults NR 100 100 56 40 4 152 48 64 33 3 161 39 8 0.609
Sirachainan et al 2008 Thailand IS Children HB 44 164 22 19 3 63 25 82 69 13 233 95 6 0.774
Biswas et al 2009 India IS Children NR 58 58 38 14 6 90 26 50 7 1 107 9 8 0.232
Morita et al 2009 America IS Children PB 23 90 17 6 0 40 6 41 36 13 118 62 6 0.278
Sawula et al 2009 Poland IS Adults HB 128 59 53 57 18 163 93 26 22 11 74 44 7 0.119
Almawi et al 2009 Bahrain MIXED Adults HB 118 120 50 38 30 138 98 54 60 6 168 72 6 0.037
Biswas et al 2009 India IS Adults HB 120 120 80 31 9 191 49 90 24 6 204 36 7 0.018
Chen et al 2010 China IS Adults HB 470 495 354 109 7 817 123 387 105 3 879 111 7 0.146
Han et al 2010 Korea IS Adults HB 264 234 179 80 5 438 90 182 51 1 415 53 8 0.193
Giusti et al 2010 Italy IS Adults HB 501 1211 248 197 56 693 309 572 529 110 1673 749 7 0.434
Hultdin et al 2011 Sweden IS Adults NR 314 767 135 142 37 412 216 328 346 93 1002 532 7 0.905
Hultdin et al 2011 Sweden HS Adults NR 59 767 29 29 1 87 31 328 346 93 1002 532 7 0.905
Arsene et al 2011 Bahrain IS Adults HB 67 60 30 28 9 88 46 25 27 8 77 43 7 0.868
Zhang et al 2012 China IS Adults HB 67 71 38 29 0 105 29 57 14 0 128 14 7 0.357
Xu et al 2012 China MIXED Adults HB 70 50 7 41 22 55 85 12 30 8 54 46 8 0.142
Zhang et al 2012 China IS Adults HB 40 40 27 12 1 66 14 33 7 0 73 7 8 0.544
Fekih-Mrissa et al 2013 Tunisia IS Adults HB 84 100 58 15 11 131 37 93 7 0 193 7 7 0.717
Gelfand et al 2013 America IS Children PB 13 84 4 7 2 15 11 39 41 4 119 49 8 0.097
Zhou et al 2014 China IS Adults HB 542 654 333 174 35 840 244 448 182 24 1078 230 8 0.308
Balcerzyk et al 2015 Poland IS Children NR 88 111 51 30 7 132 44 53 47 11 153 69 7 0.902
Lv et al 2015 China IS Adults NR 199 241 31 97 71 159 239 71 110 60 252 230 8 0.186
Wei et al 2015 Malaysia IS Adults NR 297 297 184 95 18 463 131 186 104 7 476 118 6 0.085
Kamberi et al 2016 Albania IS Adults PB 39 102 18 20 1 56 22 54 44 4 152 52 8 0.171
Herak et al 2017 Croatia IS Children HB 73 100 34 33 6 101 45 52 39 9 143 57 8 0.667
Wang et al 2017 China MIXED Adults NR 225 169 130 85 10 345 105 99 65 5 263 75 6 0.139
Zhao et al 2017 China IS Adults HB 130 100 98 32 0 228 32 68 32 0 168 32 8 0.057
Hu et al 2017 China IS Adults HB 181 169 106 67 8 279 83 99 65 5 263 75 8 0.139
Abidi et al 2018 Morocco HS Adults HB 113 323 64 46 3 174 52 186 120 17 492 154 8 0.678
Hashemi et al 2019 Iran IS Adults NR 106 157 72 31 3 175 37 120 32 5 272 42 8 0.131
Xiong et al 2019 China MIXED Adults HB 92 140 64 24 4 152 32 90 44 6 224 56 8 0.833
Mazdeh et al 2020 Iran IS Children HB 318 400 170 121 27 461 175 235 147 18 617 183 8 0.406