Fig. 9

Model indicating the  regulation of stress response, mediated by genetic interaction between SAF1 and RLM1 A. Stress mediated increased expression of RLM1 results in decreased transcription of AAH1 whereas increased transcription of SAF1 that results in post-transcriptional degradation of Aah1p in S.cerevisiae,  that may contribute to sensitivity to stress agents and transition from actively dividing state to quiescence phase B. The absence of both RLM1 and SAF1 leads to resistance phenotype in presence of a general stressor, that may result due to a steady level of Aah1p in the cells