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TableĀ 2 Histopathological changes and induction of liver micronuclei seen as very early responses of hepatocarcinogenesis

From: Detection of hepatocarcinogens by combination of liver micronucleus assay and histopathological examination in 2-week or 4-week repeated dose studies

  1. Group A: Genotoxic hepatocarcinogens, Group B: Genotoxic carcinogens but not liver targeted
  2. Mut: Liver MN induction, Ht: Hypertrophy, Pob: Proliferation oval cell or bile duct, TI: Tissue injuries, RC: Regenerative change, Inf: Inflammatory