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Table 1 Time-course changes of the % tail DNA in the corneal epithelial cells of rabbit

From: Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds

Compounds % tail DNA (%)
0.5 h 2 h 4 h 6 h 24 h
Saline 9.6 ± 4.8 (5.0) 13.4 ± 1.0 (8.3) 10.2 ± 1.3 (5.7) 9.8 ± 3.1 (3.2) 8.3 ± 1.7 (2.6)
1% EtBr 31.0 ± 3.0a (25.8) 28.1 ± 1.6a (22.6) 55.3 ± 1.4a (61.5) 41.0 ± 6.5a (40.4) 10.0 ± 4.0 (5.4)
3% MMS 66.2 ± 1.8a (70.8) 63.6 ± 4.4a (69.4) 47.1 ± 7.2a (48.9) 50.1 ± 2.8a (56.0) 40.1 ± 2.4a (38.1)
1% 4-NQO 55.2 ± 11.2a (58.3) 38.9 ± 7.8a (39.4) 35.9 ± 2.6a (36.0) 26.1 ± 2.6a (22.0) 18.7 ± 5.0a (14.5)
  1. Data are presented as the mean ± SD (n = 3). Parentheses indicate the median
  2. EtBr Ethidium bromide, MMS Methyl methanesulfonate, 4-NQO 4-nitroquinoline 1-oxide
  3. aSignificantly higher than the negative control group at 5% probability level (Student’s t-test, one-tailed)