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Table 1 Time-course changes of the % tail DNA in the corneal epithelial cells of rabbit

From: Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds

Compounds

% tail DNA (%)

0.5 h

2 h

4 h

6 h

24 h

Saline

9.6 ± 4.8 (5.0)

13.4 ± 1.0 (8.3)

10.2 ± 1.3 (5.7)

9.8 ± 3.1 (3.2)

8.3 ± 1.7 (2.6)

1% EtBr

31.0 ± 3.0a (25.8)

28.1 ± 1.6a (22.6)

55.3 ± 1.4a (61.5)

41.0 ± 6.5a (40.4)

10.0 ± 4.0 (5.4)

3% MMS

66.2 ± 1.8a (70.8)

63.6 ± 4.4a (69.4)

47.1 ± 7.2a (48.9)

50.1 ± 2.8a (56.0)

40.1 ± 2.4a (38.1)

1% 4-NQO

55.2 ± 11.2a (58.3)

38.9 ± 7.8a (39.4)

35.9 ± 2.6a (36.0)

26.1 ± 2.6a (22.0)

18.7 ± 5.0a (14.5)

  1. Data are presented as the mean ± SD (n = 3). Parentheses indicate the median
  2. EtBr Ethidium bromide, MMS Methyl methanesulfonate, 4-NQO 4-nitroquinoline 1-oxide
  3. aSignificantly higher than the negative control group at 5% probability level (Student’s t-test, one-tailed)