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Table 2 Time-course changes in the hedgehog frequency in the corneal epithelial cells of rabbit

From: Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds

Compounds

Frequency of hedgehog (%)

0.5 h

2 h

4 h

6 h

24 h

Saline

0.2 ± 0.6

1.1 ± 1.2

0.7 ± 1.0

0.7 ± 0.0

0.4 ± 0.6

1% EtBr

3.6 ± 2.5

3.3 ± 1.7

8.9 ± 3.5a

1.6 ± 2.3

0.4 ± 0.6

3% MMS

12.9 ± 7.8a

13.6 ± 8.3a

10.7 ± 1.0a

8.0 ± 2.0a

2.0 ± 1.0a

1% 4-NQO

9.8 ± 8.5a

3.8 ± 2.9

1.3 ± 1.0

1.1 ± 0.6

2.0 ± 2.0a

  1. Data are presented as the mean ± SD (n = 3)
  2. EtBr Ethidium bromide, MMS Methyl methanesulfonate, 4-NQO 4-nitroquinoline 1-oxide
  3. aSignificantly higher than the negative control group at 5% probability level (Student’s t-test, one-tailed)
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Genes and Environment

ISSN: 1880-7062

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