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Table 2 Time-course changes in the hedgehog frequency in the corneal epithelial cells of rabbit

From: Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds

Compounds Frequency of hedgehog (%)
0.5 h 2 h 4 h 6 h 24 h
Saline 0.2 ± 0.6 1.1 ± 1.2 0.7 ± 1.0 0.7 ± 0.0 0.4 ± 0.6
1% EtBr 3.6 ± 2.5 3.3 ± 1.7 8.9 ± 3.5a 1.6 ± 2.3 0.4 ± 0.6
3% MMS 12.9 ± 7.8a 13.6 ± 8.3a 10.7 ± 1.0a 8.0 ± 2.0a 2.0 ± 1.0a
1% 4-NQO 9.8 ± 8.5a 3.8 ± 2.9 1.3 ± 1.0 1.1 ± 0.6 2.0 ± 2.0a
  1. Data are presented as the mean ± SD (n = 3)
  2. EtBr Ethidium bromide, MMS Methyl methanesulfonate, 4-NQO 4-nitroquinoline 1-oxide
  3. aSignificantly higher than the negative control group at 5% probability level (Student’s t-test, one-tailed)