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Table 4 Specific gpt MF in distal colon of untreated- or DSS-treated Polk+/+ and Polk−/− mice

From: DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice

 

Water

 

DSS

 

Polk+/+

Polk−/−

Polk+/+

Polk−/−

No. of

%

SMF

No. of

%

SMF

Polk−/− / Polk+/+ (Fold)

No. of

%

SMF

No. of

%

SMF

Polk−/− / Polk+/+ (Fold)

mutant

(× 10–6)

mutant

(× 10–6)

mutant

(× 10–6)

mutant

(× 10–6)

Base substitution

 Transition

  G:C to A:T

6

35

1.6

14

37

1.9

1.2

6

33

1.3

18

29

2.9

2.2

  A:T to G:C

2

12

0.5

2

5

0.3

0.6

1

6

0.2

5

8

0.8

4.0

 Transversion

  G:C to T:A

6

35

1.6

7

18

1.0

0.6

4

22

0.9

17

27

2.8

3.1

  G:C to C:G

0

0

0.0

3

8

0.4

 

2

11

0.4

5

8

0.8

2.0

  A:T to T:A

0

0

0.0

6

16

0.8

 

1

6

0.2

7

11

1.1

5.5

  A:T to C:G

2

12

0.5

2

5

0.3

0.6

1

6

0.2

3

5

0.5

2.5

Deletion

 1 base pair

1

6

0.3

2

5

0.3

1.0

1

6

0.2

6

10

1.0

5.0

  > 2 base pairs

0

0

0.0

1

3

0.1

 

1

6

0.2

1

2

0.2

1.0

 Insertion

0

0

0.0

1

3

0.1

 

1

6

0.2

1

2

0.2

1.0

Total

17

100

4.4

38

100

5.2

1.2

18

100

4.0

63

100

10.3

2.6

  1. aSMF stands for specific MF, which was calculated by multiplying the MF by the ratio of the number of mutations in each class among the total number of gpt mutations
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Genes and Environment

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