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Fig. 4 | Genes and Environment

Fig. 4

From: Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms

Fig. 4

Interaction of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) with human and rodent CYP1A1. Placements of IQ for the N-oxidation (A, B and G), N-demethylation (C and H), inhibition (D, E), 4,5- (F) and 7,8-oxidations (I) on CYP1A1 Template are shown as 3D-structures of cylindrical shapes for pro-metabolized molecules and of stick shapes for trigger molecules. In the right-side of A-C, 90°-rotated structures are indicated in Width-gauge. A 2D-structure of IQ is shown with parts of position numbers. hCYP1A1; human CYP1A1, rCYP1A1; rodent CYP1A1. Functional and non-functional placements are indicated with dark- and grey-colored titles

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Genes and Environment

ISSN: 1880-7062

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