Fig. 5

Interaction of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline (MeIgQx) with human and rodent CYP1A1. Placements of MeIgQx for the N-oxidation (A, C and F), 6,7-oxidation (B), inhibition (D), and 4-oxidation (E) on CYP1A1 Template, for the N-oxidation on CYP1A2 Template (G, H and I) are shown as 3D-structures of cylindrical shapes for pro-metabolized molecules and of stick shapes for trigger molecules. In the right-side, 90°-rotated structures are indicated in Width-gauge. A 2D-structure of MeIgQx is shown with parts of position numbers. hCYP1A1; human CYP1A1, rCYP1A1; rodent CYP1A1. Functional and non-functional placements are indicated with dark- and grey-colored titles