Fig. 6

Interactions of typical PAHs with human and rodent CYP1A1. Placements of benzo[a]anthracene 5,6-oxidation, benzo[c]phenanthrene 5,6-oxidation, benzo[a]pyrene 4,5-oxidation, dibenzo[a,l]pyrene 8,9- (D and E), 11,12- (F) and 6,7-oxidations (6G) on CYP1A1 Template are shown as 3D-structures of cylindrical shapes for pro-metabolized molecules and of stick shapes for trigger molecules. In the right-side, 90°-rotated structures are indicated in Width-gauge. Trigger-molecules are omitted on E-G. 2D-structures of ligands are shown with parts of position numbers