Fig. 7

α-Naphthoflavone enhancement on CYP3A4 and norharman enhancement on CYP1A1. Placements of benzo[a]pyrene (BaP) 2,3-oxidation in the absence (A and B) and presence of α-naphthoflavone (ANF) (C), of benzo[e]pyrene 9,10-dihydro-9,10-diol (BeP 9,10-diol) 11,12-oxidation (D) and 2,3-oxidation (E) on CYP3A4 Template, and the 11,12-oxidation (F) on CYP1A1 Template in the presence of ANF, and of dibenzo[a,e]fluoranthene (DBF) 3,4- (G) and 12,13-oxidations (H) in the presence of norharman and the 2,3-oxidation in the absence of norharman (I) are shown as 3D-structures of cylindrical shapes for pro-metabolized molecules and of stick shapes for trigger molecules. In the right-side, 90°-rotated structures are indicated in Width-gauge, except for I. Functional and non-functional placements are indicated with dark- and grey-colored titles. Dark arrows indicate the possible cause of defects. 2D-structures of ligands are shown with parts of position numbers in the bottom