Fig. 8
Norharman enhancements on CYP enzymes and co-mutagenicity
Placements of Trp-P-2 N2-oxidation on CYP1A2 Template (A and B), and in the presence of norharman (C), of aniline for aminophenylnorharman (APNH) formation in the presence of norharman on Templates of CYP1A1 (D), CYP1A2 (E) and CYP3A4 (F), of the N-oxidation of aminomethylphenylnorharman (AMPNH) on CYP1A1 Template, and of the N-oxidations of APNH on Templates of CYP1A2 (H) and CYP2C9 (I) are shown as 3D-structures of cylindrical shapes for pro-metabolized molecules and of stick shapes for trigger molecules. In the right-side, 90°-rotated structures are indicated in Width-gauge. Grey-dashed and dark arrows indicate the possible causes of defects. and 2D-structures of ligands are shown with parts of position numbers in the bottom