TP53 mutations in Romanian patients with colorectal cancer

Genes and Environment

Table 2 Two novel frameshift TP53 mutations in Romanian patients with colorectal cancer

Sample ID	Sex	Age	Genomic co-ordinate (hg38)	Coding DNA description ^#	Genotype	Protein description	Exon number	Mutation type	Predicted mutation effect^$
RC21	M	63	g.7,676,204delA	c.165delT	t/-	p.E56Kfs*67	4-exon	frameshift	Deleterious/disease causing
RC38	M	68	g.7,673,600_7,673,593dup	c.928_935dup	-/aacaacac	p.S313Tfs*35	9-exon	frameshift	Deleterious/disease causing

^# Coding DNA is described using NM_000546.6,
^$ Mutation effect was predicted using MutationTaster2021, this web-based application tool uses Random Forest models to predict the effect of DNA variants and results are provided as tree votes in a binary prediction: deleterious (how many Random Forest decision trees indicate deleteriousness) versus benign (how many decision trees indicate benign change) [28]

ISSN: 1880-7062