Table 2 Carcinogenic epigenetic changes of benzo(a)pyrene
From: Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
Changes in methylation | Objects exposed to BaP | Reference | |
|---|---|---|---|
Genome-wide hypomethylation | 16HBE | ||
zebrafish embryo | [37], | ||
ICR mouse | [160] | ||
colorectal cancer tumor tissue | [66] | ||
Hypermethylation of specific genes | APC | human HCT116 | [156] |
c-fos, MLH1 | zebrafish embryo | [24] | |
FLT1 | 16HBE | [56] | |
DKK2, EN1 | 16HBE | [69] | |
TRIM36 | HBE | [55] | |
P14, P15, P16 | coke oven workers | [157] | |
GSTP | lung Cancer Patients | [131] | |
BCL6B | mice | [16] | |
RAR-β2 | human esophageal cancer cells | ||
RARβ, APC | Breast cancer patients | [144] | |
HIN1, CDH1 | breast cancer patients | [145] | |
eRα | mice | [117] | |
Hypomethylation of specific genes | GSTP1, CYP1A1 | 16HBE | [88] |
LINE-1, MGMT | workers exposed to PAHs | [33] | |
F2RL3, AHRR | creosote-exposed workers, chimney sweeps | [3] | |
TSC2 | human MCF-7, human HCC1806 | [115] | |
DAPK-1 | breast cancer cells | [145] | |