Table 4 Mutant frequencies in the transgenic mouse gene mutation test
Target genes | Chemicals | Doses | Mutant Frequency (×10−6) | |||
|---|---|---|---|---|---|---|
Spleen | Liver | Colon | Forestomach | |||
lacZ | Olive oil | 10 mL/kg | 40.4 ± 24.5 | 62.9 ± 10.1 | 82.5 ± 76.6 | 30.8 ± 2.7 |
AF-2 | 120 mg/kg | 30.4 ± 4.3 | 66.1 ± 8.1 | 39.9 ± 5.4 | 57.0 ± 30.7 | |
DBP | 6 mg/kg | 535.5 ± 230.0 | 280.7 ± 24.6 | 189.7 ± 40.1 | 220.4 ± 47.8 | |
cII | Olive oil | 10 mL/kg | 18.1 ± 12.5 | 31.1 ± 14.6 | 77.4 ± 65.8 | 42.6 ± 32.0 |
AF-2 | 120 mg/kg | 39.7 ± 22.9 | 45.9 ± 32.0 | 31.6 ± 10.6 | 29.8 ± 12.9 | |
DBP | 6 mg/kg | 348.9 ± 175.0 | 77.3 ± 28.4 | 123.7 ± 37.9 | 99.7 ± 15.4 | |