Fig. 3
From: Metformin suppresses proliferation and glycolysis of gastric cancer by modulating ADAMTS12
Metformin represses GC cell proliferation and glycolysis through manipulation of ADAMTS12. A: Cell viability after treatment with different concentrations of metformin as tested by CCK-8; B-C: ADAMTS12 expression after cell transfection as assayed by qRT-PCR; D: Cell viability after transfection as measured by CCK-8; E: Cell proliferation after transfection as detected via colony formation assay; F: Seahorse XP 96 analysis of ECAR and OCR of GC cells in different treatment groups; G: Detection of pyruvic acid, lactate, citrate, and malate levels in GC cells in each treatment group; H: HK-2, ATP5D and ATP5E expression after cell transfection as assayed by western blot; * P < 0.05