Fig. 1

Results of the in vivo bone marrow micronucleus test for the selective CDK4/6 inhibitor PD0332991 using rats. a Results of the %PCE and %MNPCE. White circles indicate individual %PCE, gray bars indicate mean of %MNPCE and error bars indicate standard deviation. † and * indicate statistically significant differences (†: Dunnett’s test compared with the vehicle control. Significance level was 5%, *: Fisher’s exact test and Bonferroni’s correction compared with the vehicle control. Significance level was 2.5% one-sided). b The number of PS and PL. White circles indicate individual PS, black circles indicate individual PL. * and † indicate statistically significant differences (*: Dunnett’s test compared with the vehicle control. †: Student’s t-test compared with the vehicle control. Significance level was 5%)