Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice

Genes and Environment

Table 1 Mutant frequencies in the liver of MutaMice treated with carbendazim

Substance	Dose (mg/kg/day)	Animal ID	No. of total plaques	No. of mutants	Mutant frequency (×10^− 6)	Mean ± S.D. (×10^− 6)
Corn oil	0	3001	417,600	11	26.3
		3002	363,600	12	33.0
		3003	566,100	30	53.0	40.9 ± 11.6
		3004	466,200	24	51.5
		3005	562,500	23	40.9
Carbendazim	250	3101	473,400	19	40.1
		3102	828,000	44	53.1
		3103	730,800	16	21.9	41.2 ± 12.8
		3104	399,600	21	52.6
		3105	626,400	24	38.3
	500	3201	432,000	17	39.4
		3202	343,800	11	32.0
		3203	438,300	20	45.6	39.2 ± 9.0
		3204	437,400	22	50.3
		3205	417,600	12	28.7
	1,000	3301	636,300	37	58.1
		3302	558,900	17	30.4
		3303	495,000	16	32.3	45.7 ± 15.7
		3304	304,200	20	65.7
		3305	478,800	20	41.8
ENU	100	3401	366,300	37	101.0
		3402	505,800	45	89.0
		3403	430,200	62	144.1	108.1 ± 23.8*(S)
		3404	549,900	48	87.3
		3405	302,400	36	119.0

Corn oil: Negative control (10 mL/kg)
ENU: Positive control (N -ethyl-N -nitrosourea, 10 mL/kg, i.p., dose once daily for 2 days, expression period; 10 days)
*: Significant difference from negative control (p < 0.05)
(S): Student’s t test

ISSN: 1880-7062