Fig. 1
From: Genetic susceptibility to arsenic-induced skin lesions and health effects: a review
Metabolic events upon arsenic consumption deplete the methylation pool within the cell. “**” indicates that AS3MT is a highly polymorphic enzyme. It’s polymorphic profile can determine the degree of biotransformation of inorganic arsenic within the cellular system. This may induce indirectly the epigenetic susceptibility as discussed in section Polymorphism and arsenic-induced epigenetic susceptibility