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Table 2 Formaldehyde and leukemia related major gene descriptions

From: Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach

Gene Functional class Cell process Disease
BCL2 SOD Angiogenesis, Apoptosis, DNA damage, Hemopoiesis, Inflammatory response, Oxidative stress ALL, AML, CLL, CML, Hematologic neoplasm, Hematopoietic system malignancy, Hodgkin’s disease, Leukemia, Lymphoma, Multiple myeloma, Myelodysplastic syndrome, Myeloid leukemia, non-Hodgkin’s lymphoma
DNMT3A   Apoptosis, DNA methylation, Hemopoiesis, Inflammatory response ALL, AML, CLL, CML, Hematologic neoplasm, Hematopoietic system malignancy, Leukemia, Lymphoma, Myelodysplastic syndrome, Myeloid leukemia, Myeloproliferative disorder
TNF GPx, SOD Angiogenesis, Apoptosis, DNA damage, Hemopoiesis, Inflammatory response, Oxidative stress ALL, AML, CLL, CML, Hodgkin’s disease, Leukemia, Lymphoma, Multiple myeloma, Myelodysplastic syndrome, non-Hodgkin’s lymphoma
TP53 SOD Angiogenesis, Apoptosis, DNA damage, DNA methylation, Hemopoiesis, Inflammatory response, Oxidative stress ALL, AML, Bone marrow failure, CLL, CML, Hematologic neoplasm, Hematopoietic system malignancy, Hodgkin’s disease, Leukemia, Lymphoid leukemia, Lymphoma, Multiple myeloma, Myelodysplastic syndrome, Myeloid leukemia, Myeloproliferative disorder, non-Hodgkin’s lymphoma
  1. SOD Superoxide dismutase, ALL Acute lymphoblastic leukemia, AML Acute myeloid leukemia, CLL Chronic lymphocytic leukemia, CML Chronic myeloid leukemia, GPx Glutathione peroxidase