Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach

Genes and Environment

Table 2 Formaldehyde and leukemia related major gene descriptions

Gene	Functional class	Cell process	Disease
BCL2	SOD	Angiogenesis, Apoptosis, DNA damage, Hemopoiesis, Inflammatory response, Oxidative stress	ALL, AML, CLL, CML, Hematologic neoplasm, Hematopoietic system malignancy, Hodgkin’s disease, Leukemia, Lymphoma, Multiple myeloma, Myelodysplastic syndrome, Myeloid leukemia, non-Hodgkin’s lymphoma
DNMT3A		Apoptosis, DNA methylation, Hemopoiesis, Inflammatory response	ALL, AML, CLL, CML, Hematologic neoplasm, Hematopoietic system malignancy, Leukemia, Lymphoma, Myelodysplastic syndrome, Myeloid leukemia, Myeloproliferative disorder
TNF	GPx, SOD	Angiogenesis, Apoptosis, DNA damage, Hemopoiesis, Inflammatory response, Oxidative stress	ALL, AML, CLL, CML, Hodgkin’s disease, Leukemia, Lymphoma, Multiple myeloma, Myelodysplastic syndrome, non-Hodgkin’s lymphoma
TP53	SOD	Angiogenesis, Apoptosis, DNA damage, DNA methylation, Hemopoiesis, Inflammatory response, Oxidative stress	ALL, AML, Bone marrow failure, CLL, CML, Hematologic neoplasm, Hematopoietic system malignancy, Hodgkin’s disease, Leukemia, Lymphoid leukemia, Lymphoma, Multiple myeloma, Myelodysplastic syndrome, Myeloid leukemia, Myeloproliferative disorder, non-Hodgkin’s lymphoma

SOD Superoxide dismutase, ALL Acute lymphoblastic leukemia, AML Acute myeloid leukemia, CLL Chronic lymphocytic leukemia, CML Chronic myeloid leukemia, GPx Glutathione peroxidase

ISSN: 1880-7062