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  1. Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated f...

    Authors: Shosuke Kawanishi, Shiho Ohnishi, Ning Ma, Yusuke Hiraku, Shinji Oikawa and Mariko Murata
    Citation: Genes and Environment 2017 38:26
    Content type: Review Published on:

  4. Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major products is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). The mutagenic potentials of this oxidized base have been exa...

    Authors: Tetsuya Suzuki and Hiroyuki Kamiya
    Citation: Genes and Environment 2016 39:2
    Content type: Review Published on:

    The Erratum to this article has been published in Genes and Environment 2017 39:20

  5. Actinidia arguta, known as sarunashi in Japan, is a vine tree native to east-Asia, including Japan, that produces small fruit rich in anthocyanins, catechins, vitamin C, chlorophyll, b...

    Authors: Mari Nishimura, Yuma Okimasu, Naoko Miyake, Misako Tada, Ryoko Hida, Tomoe Negishi and Sakae Arimoto-Kobayashi
    Citation: Genes and Environment 2016 38:25
    Content type: Research Published on:

  6. We investigated the enhancing effect of metal ions on several mutagens and examined their mechanism of action. We performed the Ames tests on six mutagens, i.e., 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, 4-ni...

    Authors: Nobuyoshi Fujii, Shigemitsu Yano and Kenji Takeshita
    Citation: Genes and Environment 2016 38:21
    Content type: Research Published on:

  8. Carcinogens are known to cause swelling of the mammalian cell nucleus. However, the mechanism of the swelling and its toxicological significance have not been fully elucidated. Since nuclear swelling (NS herea...

    Authors: Kenji Takeshita, Hiroaki I. Ogawa and Toshinari Maeda
    Citation: Genes and Environment 2016 38:22
    Content type: Research Published on:

  10. Cytosine residues in CpG dinucleotides often undergo various types of modification, such as methylation, deamination, and halogenation. These types of modifications can be pro-mutagenic and can contribute to t...

    Authors: Akira Sassa, Yuki Kanemaru, Nagisa Kamoshita, Masamitsu Honma and Manabu Yasui
    Citation: Genes and Environment 2016 38:17
    Content type: Short report Published on:

  12. Toxicogenomics is a rapidly developing discipline focused on the elucidation of the molecular and cellular effects of chemicals on biological systems. As a collaborative study group of Toxicogenomics/JEMS·MMS,...

    Authors: Chie Furihata, Takashi Watanabe, Takayoshi Suzuki, Shuichi Hamada and Madoka Nakajima
    Citation: Genes and Environment 2016 38:15
    Content type: Review Published on:

  13. Cancer is now the leading cause of death in Japan. A rapid increase in cancer mortality is expected as Japan is facing a super-aged society. Many causes of cancer are known to be closely linked to life style f...

    Authors: Yasusei Kudo, Hidesuke Tada, Natsumi Fujiwara, Yoshiko Tada, Takaaki Tsunematsu, Yoichiro Miyake and Naozumi Ishimaru
    Citation: Genes and Environment 2016 38:13
    Content type: Review Published on:

  16. The editors of Genes and Environment would like to thank all our reviewers who have contributed to the journal in Volume XXXVII (2015).

    Authors: Takashi Yagi
    Citation: Genes and Environment 2016 39:1
    Content type: Reviewer acknowledgement Published on:

    The Erratum to this article has been published in Genes and Environment 2017 39:20

  17. The linear no-threshold model (LNT) has been the basis for radiation protection policies worldwide for 60 years. LNT was fabricated without correct data. The lifespan study of Atomic bomb survivors (LSS) has p...

    Authors: Shizuyo Sutou
    Citation: Genes and Environment 2016 38:12
    Content type: Commentary Published on:

  18. The mucosal immune system is unique to the gastrointestinal mucosa, in which a large number of immune cells are located and exert multiple functions. Meanwhile, ~100 trillion microorganisms are thought to co-i...

    Authors: Mayuko Yamamoto and Satoshi Matsumoto
    Citation: Genes and Environment 2016 38:11
    Content type: Review Published on:

  21. Germline mutations are heritable and may cause health disadvantages in the next generation. To investigate trans-generational mutations, we treated male gpt delta mice with N-ethyl-N-nitrosourea (ENU) (85 mg/kg i...

    Authors: Kenichi Masumura, Naomi Toyoda-Hokaiwado, Akiko Ukai, Yoichi Gondo, Masamitsu Honma and Takehiko Nohmi
    Citation: Genes and Environment 2016 38:10
    Content type: Research Published on:

  22. Evidence from epidemiological and experimental studies has shown that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colorectal cancer (CRC). The function of NSAIDs and the molecular targets...

    Authors: Takahiro Hamoya, Gen Fujii, Shingo Miyamoto, Mami Takahashi, Yukari Totsuka, Keiji Wakabayashi, Jiro Toshima and Michihiro Mutoh
    Citation: Genes and Environment 2016 38:6
    Content type: Review Published on:

  23. Pesticide exposure possesses risk of genotoxicity to humans, particularly farmers. Despite accumulating evidences linking genotoxicity to pesticide exposure, epidemiological studies to address pesticide toxici...

    Authors: Zariyantey Abdul Hamid, Mohd Faizal Mohd Zulkifly, Asmah Hamid, Syarif Husin Lubis, Nihayah Mohammad, Ismarulyusda Ishak, Nur Zakiah Mohd Saat, Hidayatul Fathi Othman, Ahmad Rohi Ghazali, Mohd Jamil Mohd Rafaai, Mohamad Roff Mohd Noor and Nor Fadilah Rajab
    Citation: Genes and Environment 2016 38:7
    Content type: Research Published on:

  24. The study was carried out to identify the polymorphisms in mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo population and to correlate the involvement of demographic factors.

    Authors: Freda Lalrohlui, Sunaina Thapa, Souvik Ghatak, John Zohmingthanga and Nachimuthu Senthil Kumar
    Citation: Genes and Environment 2016 38:5
    Content type: Short report Published on:

  26. Several alkenylbenzenes, including methyleugenol (ME), are present in a wide range of botanicals and exhibit carcinogenic and mutagenic properties. Negative results are generally obtained for alkenylbenzenes i...

    Authors: Hiroshi Honda, Kazuyuki Minegawa, Yurika Fujita, Noriko Yamaguchi, Yoshihiro Oguma, Hansruedi Glatt, Naohiro Nishiyama and Toshio Kasamatsu
    Citation: Genes and Environment 2016 38:1
    Content type: Short report Published on:

  27. Tobacco smoking is a major cause of lung cancer. It has been suggested that there is an approximately linear dose–response relationship between the number of cigarettes smoked per day and clinical outcome such...

    Authors: Masahiko Watanabe
    Citation: Genes and Environment 2016 38:3
    Content type: Review Published on:

  28. The bacterial reverse mutation test, commonly called Ames test, is used worldwide. In Japan, the genetically modified organisms (GMOs) are regulated under the Cartagena Domestic Law, and organisms obtained by ...

    Authors: Kei-ichi Sugiyama, Masami Yamada, Takumi Awogi and Atsushi Hakura
    Citation: Genes and Environment 2016 38:2
    Content type: Commentary Published on:

  29. Asian dust events, transport of dust particles from arid and semi-arid areas in China and Mongolia to the east by prevailing westerlies, are often observed in Japan in spring. In recent decades, consumption of...

    Authors: Souleymane Coulibaly, Hiroki Minami, Maho Abe, Tomohiro Hasei, Tadashi Oro, Kunihiro Funasaka, Daichi Asakawa, Masanari Watanabe, Naoko Honda, Keiji Wakabayashi and Tetsushi Watanabe
    Citation: Genes and Environment 2015 37:25
    Content type: Research Published on:

  30. Transgenic gpt delta mouse and rat models were developed to perform gpt and Spi− assays for in vivo mutagenicity tests. The animals were established by integration of lambda EG10 phage DNA as a transgene into the...

    Authors: Kenichi Masumura, Yasuteru Sakamoto, Wakako Kumita, Masamitsu Honma, Akiyoshi Nishikawa and Takehiko Nohmi
    Citation: Genes and Environment 2015 37:24
    Content type: Research Published on:

  32. 2,2,4-Triamino-5(2H)-oxazolone (Oz) in a DNA strand is an oxidation product of guanine and 8-oxo-7, 8-dihydroguanine, and such a lesion can cause G-to-C transversions. Previously, Fpg/Nei and Nth were shown to ha...

    Authors: Katsuhito Kino, Masayo Suzuki, Masayuki Morikawa, Takanobu Kobayashi, Shigenori Iwai and Hiroshi Miyazawa
    Citation: Genes and Environment 2015 37:22
    Content type: Short report Published on:

  35. The nicotinic α5 receptor subunit, encoded by CHRNA5, harbors multiple functional single nucleotide polymorphisms (SNPs) that affect mRNA expression and alter the encoded protein. These polymorphisms are most not...

    Authors: Jessica E. Ramsay, C. Harker Rhodes, Keerthi Thirtamara-Rajamani and Ryan M. Smith
    Citation: Genes and Environment 2015 37:14
    Content type: Research article Published on:

  36. Progerin, the protein responsible for the Hutchinson-Gilford Progeria Syndrome (HGPS), is a partially deleted form of nuclear lamin A, and its expression has been suggested as a cause for dysfunctional nuclear...

    Authors: Asao Noda, Shuji Mishima, Yuko Hirai, Kanya Hamasaki, Reid D. Landes, Hiroshi Mitani, Kei Haga, Tohru Kiyono, Nori Nakamura and Yoshiaki Kodama
    Citation: Genes and Environment 2015 37:13
    Content type: Research article Published on:

  37. The 4th Asian Conference on Environmental Mutagens was held at CSIR Indian Institute of Chemical Biology, Kolkata, during December 10–12, 2014, in collaboration with All India Congress of Cytology and Genetics...

    Authors: Ashok K. Giri and Takashi Yagi
    Citation: Genes and Environment 2015 37:19
    Content type: Meeting report Published on:

  38. According to published information, it has not been determined whether the inhalation of cigarette smoke can induce chromosome aberrations and/or point mutations in mice, though cigarette smoke is clearly carc...

    Authors: Takanori Nakamura, Yumi Ishida, Kasumi Ainai, Shigeto Nakamura, Satoru Shirata, Kazuhiro Murayama, Shin-ichiro Kurimoto, Katsuyasu Saigo, Ryo Murashige, Shuji Tsuda and Yu F. Sasaki
    Citation: Genes and Environment 2015 37:17
    Content type: Research article Published on:

  40. Here we describe recent advances in our understanding of the natural history of the house mouse, Mus musculus, with a focus on the genetic characteristics of the home territories and how this relates to prehistor...

    Authors: Hitoshi Suzuki, Lyudmila V. Yakimenko, Daiki Usuda and Liubov V. Frisman
    Citation: Genes and Environment 2015 37:20
    Content type: Review Published on:

  41. In DNA, 8-oxo-7,8-dihydroguanine (GO, 8-hydroxyguanine) is one of the most pivotal oxidatively damaged bases and induces G:C → T:A transversion mutations. DNA polymerase λ preferentially inserts dCTP opposite GO ...

    Authors: Hiroyuki Kamiya, Masahiro Kurokawa, Tetsuaki Makino, Miwako Kobayashi and Ichiro Matsuoka
    Citation: Genes and Environment 2015 37:10
    Content type: Research article Published on:

  43. Biological studies in animals and epidemiological findings in humans clearly demonstrate that estrogens including 17β-estradiol (E2) are weak carcinogens via both genetic and epigenetic mechanisms. Carcinogene...

    Authors: Zhuhong Zhang, Haifang Li, Mugimane G. Manjanatha, Tao Chen and Nan Mei
    Citation: Genes and Environment 2015 37:16
    Content type: Research article Published on:

  44. The Public Symposium of the Japanese Environmental Mutagen Society (JEMS), entitled “Regulatory Science”, was held at the Shiba-Kyoritsu campus of Keio University, Tokyo, on May 24, 2014. The concept of regula...

    Authors: Hajime Kojima and Toshio Kasamatsu
    Citation: Genes and Environment 2015 37:12
    Content type: Meeting report Published on:

  45. Hepatic cytochrome P450s (CYPs) play an important role in the metabolism of plant carcinogen, aristolochic acid I (AAI). In the present study, we employed hepatic NADPH-cytochrome P450 reductase null (HRN) gpt de...

    Authors: Yang Luan, Guozhen Xing, Jin Ren and Jun Gu
    Citation: Genes and Environment 2015 37:11
    Content type: Research article Published on:

  47. Asbestos-induced formation of mesothelioma has been attributed to phenotypic and morphological changes in cells caused by polyploidization and aneuploidization, and multiwalled carbon nanotubes (MWCNTs) are su...

    Authors: Manabu Yasui, Nagisa Kamoshita, Tetsuji Nishimura and Masamitsu Honma
    Citation: Genes and Environment 2015 37:6
    Content type: Short report Published on:

  48. Genes and Environment is now at the start of a new era of publication as an open access journal. I believe that open access publication marks a turning point that will make Genes and Environment unique in the Asi...

    Authors: Yasunobu Aoki
    Citation: Genes and Environment 2015 37:5
    Content type: Letter to the Editor Published on:

  50. The Health and Environmental Sciences Institute (HESI) is a non-profit scientific research organization based in Washington, D.C., U.S.A. HESI was established in 1989 as a global branch of the International Li...

    Authors: Ayako Takei
    Citation: Genes and Environment 2015 37:1
    Content type: Review Published on:

Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).

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