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  1. Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity...

    Authors: Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata and Masamitsu Honma
    Citation: Genes and Environment 2021 43:16
    Content type: Research Published on:

  2. CRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result ...

    Authors: Hussein Sabit, Shaimaa Abdel-Ghany, Huseyin Tombuloglu, Emre Cevik, Amany Alqosaibi, Fatma Almulhim and Afnan Al-Muhanaa
    Citation: Genes and Environment 2021 43:15
    Content type: Review Published on:

  3. Cancer is one of the main health challenges and leading causes of deaths in the world. Various environmental and genetic risk factors are associated with tumorigenesis. Epigenetic deregulations are also import...

    Authors: Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Abbaszadegan and Meysam Moghbeli
    Citation: Genes and Environment 2021 43:14
    Content type: Review Published on:

  4. Formaldehyde is a widely used but highly reactive and toxic chemical. The International Agency for Research on Cancer classifies formaldehyde as a Group 1 carcinogen, based on nasopharyngeal cancer and leukemi...

    Authors: Doo Seok Kang, Hyun Soo Kim, Jong-Hyeon Jung, Cheol Min Lee, Yeon-Soon Ahn and Young Rok Seo
    Citation: Genes and Environment 2021 43:13
    Content type: Review Published on:

  5. A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings. Recent technological developments have f...

    Authors: Ippei Ohnishi, Yuji Iwashita, Yuto Matsushita, Shunsuke Ohtsuka, Takashi Yamashita, Keisuke Inaba, Atsuko Fukazawa, Hideto Ochiai, Keigo Matsumoto, Nobuhito Kurono, Yoshitaka Matsushima, Hiroki Mori, Shioto Suzuki, Shohachi Suzuki, Fumihiko Tanioka and Haruhiko Sugimura
    Citation: Genes and Environment 2021 43:12
    Content type: Research Published on:

  6. The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue. The comet assay of hepatocytes is well established; however, t...

    Authors: Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono and Masaaki Kurata
    Citation: Genes and Environment 2021 43:11
    Content type: Research Published on:

  7. The PIGRET assay is one of the Pig-a assays targeting reticulocytes (RETs), an in vivo genotoxicity evaluation method using flow cytometry with endogenous reporter glycosylphosphatidylinositol anchor protein. The...

    Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata
    Citation: Genes and Environment 2021 43:10
    Content type: Method Published on:

  8. Radio-adaptive response (RAR) is transient phenomena, where cells conditioned with a small dose (priming) of ionizing radiation shows significantly reduced DNA damage with a subsequent high challenging dose. T...

    Authors: Shridevi Shelke and Birajalaxmi Das
    Citation: Genes and Environment 2021 43:9
    Content type: Research Published on:

  10. Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagen...

    Authors: Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura…
    Citation: Genes and Environment 2021 43:7
    Content type: Research Published on:

  11. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Marzieh Siavashifar, Fatemeh Rezaei, Tahereh Motallebirad, Davood Azadi, Abdorrahim Absalan, Zahra Naserramezani, Mohadeseh Golshani, Morteza Jafarinia and Kazem Ghaffari
    Citation: Genes and Environment 2021 43:6
    Content type: Correction Published on:

    The original article was published in Genes and Environment 2021 43:2

  13. Acrylamide (AA) is a rodent carcinogen and classified by the IARC into Group 2A (probable human carcinogen). AA has been reported to induce mutations in transgenic rodent gene mutation assays (TGR assays), the...

    Authors: Soichiro Hagio, Naho Tsuji, Satoshi Furukawa, Kazuya Takeuchi, Seigo Hayashi, Yusuke Kuroda, Masamitsu Honma and Kenichi Masumura
    Citation: Genes and Environment 2021 43:4
    Content type: Research Published on:

  14. There are very few studies covering the epidemiological risk factors associated with Epstein Barr Virus (EBV) and Microsatellite stability for Gastric Cancer (GC) cases. Early diagnosis of GC through epidemiologi...

    Authors: Payel Chakraborty, Souvik Ghatak, Saia Chenkual, Lalawmpuii Pachuau, John Zohmingthanga, Zothankima Bawihtlung, Lalfakzuala Khenglawt, Jeremy L. Pautu, Arindam Maitra, Lalchhandama Chhakchhuak and Nachimuthu Senthil Kumar
    Citation: Genes and Environment 2021 43:3
    Content type: Research Published on:

  15. Hospital environmental resources have a significant role in cross-transmission of opportunistic pathogens such as actinomycetes species to the patients. Actinomycetes have a remarkable capability to survive in...

    Authors: Marzieh Siavashifar, Fatemeh Rezaei, Tahereh Motallebirad, Davood Azadi, Abdorrahim Absalan, Zahra Naserramezani, Mohadeseh Golshani, Morteza Jafarinia and Kazem Ghaffari
    Citation: Genes and Environment 2021 43:2
    Content type: Research Published on:

    The Correction to this article has been published in Genes and Environment 2021 43:6

  16. Coronary Artery Disease (CAD) is caused by the blockage of the coronary arteries. it is argued that there has an association between the Interleukin-6 gene and the occurrence of atherosclerosis, coronary arter...

    Authors: Nader Salari, Kamran Mansouri, Amin Hosseinian-Far, Hooman Ghasemi, Masoud Mohammadi, Rostam Jalali and Aliakbar Vaisi-Raygani
    Citation: Genes and Environment 2021 43:1
    Content type: Research Published on:

  18. (Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies. We evalu...

    Authors: Masamitsu Honma, Airi Kitazawa, Toshio Kasamatsu and Kei-ichi Sugiyama
    Citation: Genes and Environment 2020 42:32
    Content type: Research Published on:

  19. The 6th Asian Congress on Environmental Mutagens (ACEM) was held at Hitotsubashi Hall, Chiyoda City, Tokyo on November 18–20, 2019, in conjunction with the 48th Annual Meeting of the Japanese Environmental Mut...

    Authors: Masamitsu Honma
    Citation: Genes and Environment 2020 42:30
    Content type: Meeting report Published on:

  20. DNA damage is generated by various intrinsic and extrinsic sources such as reactive oxygen species (ROS) and environmental mutagens, and causes genomic alterations. DNA damage response (DDR) is activated to in...

    Authors: Ako Matsui, Kazunari Hashiguchi, Masao Suzuki and Qiu-Mei Zhang-Akiyama
    Citation: Genes and Environment 2020 42:29
    Content type: Short report Published on:

  22. The use of in silico predictions for the assessment of bacterial mutagenicity under the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline is...

    Authors: Robert S. Foster, Adrian Fowkes, Alex Cayley, Andrew Thresher, Anne-Laure D. Werner, Chris G. Barber, Grace Kocks, Rachael E. Tennant, Richard V. Williams, Steven Kane and Susanne A. Stalford
    Citation: Genes and Environment 2020 42:27
    Content type: Short report Published on:

  23. Urinary nicotine and cotinine levels are often measured as biomarkers for tobacco smoke exposure. However, these biomarkers are not appropriate to evaluate the effects of quitting smoking for several days, bec...

    Authors: Yuya Kawasaki, Yun-Shan Li, Yuko Ootsuyama, Kazuhiko Nagata, Hiroshi Yamato and Kazuaki Kawai
    Citation: Genes and Environment 2020 42:26
    Content type: Research Published on:

  24. Hydroxychloroquine (HCQ) and Chloroquine (CQ) are two anti-malarial drugs that are now being extensively used by front-line healthcare workers and other common people as a prophylactic drug against the Corona ...

    Authors: Allan Giri, Ankita Das, Ajoy K. Sarkar and Ashok K. Giri
    Citation: Genes and Environment 2020 42:25
    Content type: Review Published on:

  25. Melanoma Antigen Genes (MAGEs) are a family of genes that have piqued the interest of scientists for their unique expression pattern. A subset of MAGEs (Type I) are expressed in spermatogonial cells and in no ...

    Authors: Ashley Colemon, Taylor M. Harris and Saumya Ramanathan
    Citation: Genes and Environment 2020 42:24
    Content type: Research Published on:

  27. Rare earth minerals of the lanthanide series are widely used in the field of medical and clinical application. Gadolinium (Gd), the most preferred rare earth mineral is frequently used as magnets, superconduct...

    Authors: Ee Ling Siew, Ahmad Faizzudin Farris, Noramiwati Rashid, Kok Meng Chan and Nor Fadilah Rajab
    Citation: Genes and Environment 2020 42:22
    Content type: Research Published on:

  28. Exogenous formaldehyde is classified by the IARC as a Category 1 known human carcinogen. Meanwhile, a significant amount of endogenous formaldehyde is produced in the human body; as such, formaldehyde-derived ...

    Authors: Jun Nakamura, Darcy W. Holley, Toshihiro Kawamoto and Scott J. Bultman
    Citation: Genes and Environment 2020 42:21
    Content type: Short report Published on:

  29. Sex steroid hormone receptors are classified into three classes of receptors: estrogen receptors (ER) α and β, androgen receptor (AR), and progesterone receptor (PR). They belong to the nuclear receptor superf...

    Authors: Sayoko Ito-Harashima, Mami Matano, Kana Onishi, Tomofumi Nomura, Saki Nakajima, Shingo Ebata, Kazuhiro Shiizaki, Masanobu Kawanishi and Takashi Yagi
    Citation: Genes and Environment 2020 42:20
    Content type: Research Published on:

  30. DNA-dependent protein kinase (DNA-PK), consisting of a Ku heterodimer (Ku70/80) and a large catalytic subunit (DNA-PKcs), plays an important role in the repair of DNA double-strand breaks via non-homologous en...

    Authors: Kenichi Masumura, Fumio Yatagai, Masako Ochiai, Hitoshi Nakagama and Takehiko Nohmi
    Citation: Genes and Environment 2020 42:19
    Content type: Short report Published on:

  32. In the course of our research to investigate the cancer prevention potency of natural products derived from plant materials, we isolated fifty-five compounds, including twenty-one new compounds from the peels of

    Authors: Takahiro Matsumoto and Tetsushi Watanabe
    Citation: Genes and Environment 2020 42:17
    Content type: Review Published on:

  33. Kaolin is a clay mineral with the chemical composition Al2Si2O5(OH)4. It is an important industrial material, and is also used as a white cosmetic pigment. We previously reported that fine particles of kaolin hav...

    Authors: Masanobu Kawanishi, Reimi Yoneda, Yukari Totsuka and Takashi Yagi
    Citation: Genes and Environment 2020 42:16
    Content type: Short report Published on:

  34. Various challenges have been overcome with regard to applying ‘omics technologies for chemical risk assessments. Previously we published results detailing targeted mRNA sequencing (RNA-Seq) on a next generatio...

    Authors: Chie Furihata, Xinyue You, Takeshi Toyoda, Kumiko Ogawa and Takayoshi Suzuki
    Citation: Genes and Environment 2020 42:15
    Content type: Short report Published on:

  35. The standard Ames test strains owe their high sensitivity to chemical and physical mutagens to the episomal Y-family DNA polymerase RI encoded by the mucAB operon. The S. typhimurium test strains carry also anoth...

    Authors: Petr Grúz, Masatomi Shimizu, Kei-ichi Sugiyama, Masami Yamada and Masamitsu Honma
    Citation: Genes and Environment 2020 42:14
    Content type: Research Published on:

  36. The endocrine disruptor Bisphenol-A (BPA), has been involved in dysregulating adipose tissue development and increasing the risk of obesity. The objective of this experiment was to investigate whether treatmen...

    Authors: Amin Salehpour, Farzad Shidfar, Mehdi Hedayati, Asal Neshatbini Tehrani, Ali Asghar Farshad and Saeed Mohammadi
    Citation: Genes and Environment 2020 42:13
    Content type: Research Published on:

  37. Colibactin is a small genotoxic molecule produced by enteric bacteria, including certain Escherichia coli (E. coli) strains harbored in the human large intestine. This polyketide-peptide genotoxin is considered t...

    Authors: Masanobu Kawanishi, Chiaki Shimohara, Yoshimitsu Oda, Yuuta Hisatomi, Yuta Tsunematsu, Michio Sato, Yuichiro Hirayama, Noriyuki Miyoshi, Yuji Iwashita, Yuko Yoshikawa, Haruhiko Sugimura, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Takashi Yagi and Kenji Watanabe
    Citation: Genes and Environment 2020 42:12
    Content type: Short report Published on:

  39. In the original publication of this article [1], the author made a correction but wasn’t carried out.

    Authors: Tetsuya Suzuki, Nobuhiko Miura, Rieko Hojo, Yukie Yanagiba, Megumi Suda, Tatsuya Hasegawa, Muneyuki Miyagawa and Rui-Sheng Wang
    Citation: Genes and Environment 2020 42:10
    Content type: Correction Published on:

    The original article was published in Genes and Environment 2020 42:7

  40. Translesion synthesis (TLS) is an error-prone pathway required to overcome replication blockage by DNA damage. Aberrant activation of TLS has been suggested to play a role in tumorigenesis by promoting genetic...

    Authors: Megumi Sasatani, Elena Karamfilova Zaharieva and Kenji Kamiya
    Citation: Genes and Environment 2020 42:9
    Content type: Review Published on:

  41. Next Generation Sequencer (NGS) is a powerful tool for a high-throughput sequencing of human genome. It is important to ensure reliability and sensitivity of the sequence data for a clinical use of the NGS. Va...

    Authors: Takayoshi Suzuki, Yoshinori Tsukumo, Chie Furihata, Mikihiko Naito and Arihiro Kohara
    Citation: Genes and Environment 2020 42:8
    Content type: Short report Published on:

  42. A variety of in vivo and in vitro studies to assess the genotoxicity of titanium dioxide nanoparticles (TiO2 NPs) have been reported, but the results are inconsistent. Recently, we reported that TiO2 NPs exhibit ...

    Authors: Tetsuya Suzuki, Nobuhiko Miura, Rieko Hojo, Yukie Yanagiba, Megumi Suda, Tatsuya Hasegawa, Muneyuki Miyagawa and Rui-Sheng Wang
    Citation: Genes and Environment 2020 42:7
    Content type: Research Published on:

    The Correction to this article has been published in Genes and Environment 2020 42:10

  43. There is increasing evidence indicating an incidence of infertility and also the risk of endometrial cancers among smokers. However, the mechanism underlying nicotine adverse effect on female reproduction rema...

    Authors: Fatemeh Zal, Amir Yarahmadi, Hamidreza Totonchi, Mahdi Barazesh and Mostafa Moradi Sarabi
    Citation: Genes and Environment 2020 42:6
    Content type: Research Published on:

  44. Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards and modes of action for chemical toxicology. In ge...

    Authors: Julie K. Buick, Andrew Williams, Rémi Gagné, Carol D. Swartz, Leslie Recio, Stephen S. Ferguson and Carole L. Yauk
    Citation: Genes and Environment 2020 42:5
    Content type: Research Published on:

  45. It has yet to be determined whether or not the probability of developing cancer due to radiation exposure levels of low doses is proportional to the dose. Herein, for radiation hormesis occurring at low doses,...

    Authors: Katsuhito Kino
    Citation: Genes and Environment 2020 42:4
    Content type: Commentary Published on:

  46. Acetone is a common alternative solvent used in the Ames test when test chemicals are unstable or poorly soluble in water or dimethyl sulfoxide (DMSO). Yet, there is a very limited number of studies evaluating...

    Authors: Tomomi Shibata, Takeshi Yamagata, Akihiro Kawade, Shoji Asakura, Naoki Toritsuka, Naoki Koyama and Atsushi Hakura
    Citation: Genes and Environment 2020 42:3
    Content type: Research Published on:

  47. Acetaldehyde, produced upon exposure to alcohol, cigarette smoke, polluted air and sugar, is a highly reactive compound that is carcinogenic to humans and causes a variety of DNA lesions in living human cells....

    Authors: Haruka Tsuruta, Yuina Sonohara, Kosuke Tohashi, Narumi Aoki Shioi, Shigenori Iwai and Isao Kuraoka
    Citation: Genes and Environment 2020 42:2
    Content type: Research Published on:

  49. Surface waters receive a variety of organic pollutants via wastewater discharge, and sediment represents a sink for hydrophobic contaminants. In this study, we used in vitro yeast-based reporter gene assays an...

    Authors: Pei-Hsin Chou, Chien-Hsun Chen, Kuang-Yu Chen, Fung-Chi Ko, Tsung-Ya Tsai and Yi-Po Yeh
    Citation: Genes and Environment 2019 41:24
    Content type: Research Published on:

  50. Development of chemotherapeutic/preventive drugs that selectively kill cancer - the Holy Grail of cancer research - is a major challenge. A particular difficulty arises when chemotherapeutics and radiation are...

    Authors: John R. Ridpath and Jun Nakamura
    Citation: Genes and Environment 2019 41:23
    Content type: Short report Published on:

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