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  1. Ames test is used worldwide for detecting the bacterial mutagenicity of chemicals. In silico analyses of bacterial mutagenicity have recently gained acceptance by regulatory agencies; however, current in silico m...

    Authors: Atsushi Hakura, Takumi Awogi, Toshiyuki Shiragiku, Atsushi Ohigashi, Mika Yamamoto, Kayoko Kanasaki, Hiroaki Oka, Yasuaki Dewa, Shunsuke Ozawa, Kouji Sakamoto, Tatsuya Kato and Eiji Yamamura
    Citation: Genes and Environment 2021 43:41
    Content type: Research Published on:

  2. Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately...

    Authors: Xiaobo Dong, Jun Wang, Gesheng Wang, Jiayue Wang, Lei Wang and Yong Du
    Citation: Genes and Environment 2021 43:40
    Content type: Research Published on:

  3. Due to the complex structure and function of central nervous system (CNS), human CNS in vitro modeling is still a great challenge. Neurotoxicity testing of environmental chemicals mainly depends on the traditi...

    Authors: Yuanyuan Zheng, Fangrong Zhang, Shengmin Xu and Lijun Wu
    Citation: Genes and Environment 2021 43:39
    Content type: Review Published on:

  4. Chemical carcinogens to humans have been usually identified by epidemiological studies on the relationships between occupational or environmental exposure to the agents and specific cancer induction. In contra...

    Authors: Takehiko Nohmi and Masahiko Watanabe
    Citation: Genes and Environment 2021 43:38
    Content type: Review Published on:

  5. The liver micronucleus (MN) assay is an effective and important in vivo test for detecting genotoxic compounds. In particular, the repeated-dose liver MN (RDLMN) assay which greatly facilitates incorporation o...

    Authors: Miyuki Shigano, Hironao Takasawa and Shuichi Hamada
    Citation: Genes and Environment 2021 43:37
    Content type: Short report Published on:

  6. Pentavalent antimonial compounds are currently used to treat leishmaniasis and resistance to these drugs is a serious problem. Multidrug resistance protein is an efflux pump of the cell membrane that expels fo...

    Authors: Maryam Fekri Soofi Abadi, Alireza Moradabadi, Reza Vahidi, Saeedeh Shojaeepour, Sara Rostami, Iman Rad and Shahriar Dabiri
    Citation: Genes and Environment 2021 43:36
    Content type: Research Published on:

  7. Peroxiredoxin 1 (PRDX1) is a member of a ubiquitous family of thiol peroxidases that catalyze the reduction of peroxides, including hydrogen peroxide. It functions as an antioxidant enzyme, similar to catalase...

    Authors: Takahito Moriwaki, Akari Yoshimura, Yuki Tamari, Hiroyuki Sasanuma, Shunichi Takeda, Masayuki Seki and Keizo Tano
    Citation: Genes and Environment 2021 43:35
    Content type: Research Published on:

  8. Multi-walled carbon nanotube (MWCNT) is one of the most widely used manufactured nanomaterials, however, its potential harmful effect on human health is of great concern. Previously we have shown the acute and...

    Authors: Li Ju, Lijin Zhu, Hao Wu, Min Yu, Xianhong Yin, Zhenyu Jia, Lingfang Feng, Shibo Ying, Hailing Xia, Shuzhi Zhang, Jianlin Lou and Jun Yang
    Citation: Genes and Environment 2021 43:34
    Content type: Research Published on:

  12. Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA...

    Authors: Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama and Kenichi Masumura
    Citation: Genes and Environment 2021 43:30
    Content type: Research Published on:

  14. Alcohol consumption and the ingestion of red meat and oxidized cooking oil are risk factors of gastric and colorectal cancers. We reported that acetaldehyde (AcAld) is generated from Heme/Mb/Meat-Linoleate-EtO...

    Authors: Hiroshi Kasai and Kazuaki Kawai
    Citation: Genes and Environment 2021 43:28
    Content type: Research Published on:

  15. Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the ty...

    Authors: Yasunobu Aoki, Mizuki Ohno, Michiyo Matsumoto, Michi Matsumoto, Kenichi Masumura, Takehiko Nohmi and Teruhisa Tsuzuki
    Citation: Genes and Environment 2021 43:27
    Content type: Research Published on:

  16. To evaluate the relationship between transcription factor 7-like 2 (TCF7L2) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han p...

    Authors: Peng Xue, Haihong Cao, Zhimin Ma, Ying Zhou and Nian Wang
    Citation: Genes and Environment 2021 43:26
    Content type: Research Published on:

  17. Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have...

    Authors: Kenichi Masumura, Tomoko Ando, Akiko Ukai, Sho Fujiwara, Shigeo Yokose, Xinyue You, Takayoshi Suzuki, Hiroyuki Hayashi, Takehiko Nohmi, Hisayoshi Takagi and Masamitsu Honma
    Citation: Genes and Environment 2021 43:25
    Content type: Research Published on:

  19. Exposure to respirable crystalline silica (RCS) can induce accelerated silicosis (AS), a form of silicosis that is more progressive and severe form of silicosis. In this project we aimed to assess processes of...

    Authors: Linlin Sai, Xuejie Qi, Gongchang Yu, Juan Zhang, Yuxin Zheng, Qiang Jia and Cheng Peng
    Citation: Genes and Environment 2021 43:23
    Content type: Research Published on:

  20. Malaria is a disease annually causing over 400,000 deaths. Deep understanding of molecular and genetic processes underlying its life cycle and pathogenicity is required to efficiently resist it. RNA interferen...

    Authors: Alexandr Grinev, Natalya Fokina, Denis Bogomolov, Iza Berechikidze and Yuliya Lazareva
    Citation: Genes and Environment 2021 43:22
    Content type: Research Published on:

  23. We designed a case-control study to investigate the effect of vitamin D receptor gene (VDR) gene single nucleotide polymorphisms (SNPs) and possible gene- environment interaction on the susceptibility of renal...

    Authors: Tian Jianhai, Lv Jian, Zhang Long, Wang Wei, Zhang Shumao, Wang Yiming and Li Xiaojuan
    Citation: Genes and Environment 2021 43:19
    Content type: Research Published on:

  26. Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity...

    Authors: Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata and Masamitsu Honma
    Citation: Genes and Environment 2021 43:16
    Content type: Research Published on:

  27. CRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result ...

    Authors: Hussein Sabit, Shaimaa Abdel-Ghany, Huseyin Tombuloglu, Emre Cevik, Amany Alqosaibi, Fatma Almulhim and Afnan Al-Muhanaa
    Citation: Genes and Environment 2021 43:15
    Content type: Review Published on:

  28. Cancer is one of the main health challenges and leading causes of deaths in the world. Various environmental and genetic risk factors are associated with tumorigenesis. Epigenetic deregulations are also import...

    Authors: Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Abbaszadegan and Meysam Moghbeli
    Citation: Genes and Environment 2021 43:14
    Content type: Review Published on:

  29. Formaldehyde is a widely used but highly reactive and toxic chemical. The International Agency for Research on Cancer classifies formaldehyde as a Group 1 carcinogen, based on nasopharyngeal cancer and leukemi...

    Authors: Doo Seok Kang, Hyun Soo Kim, Jong-Hyeon Jung, Cheol Min Lee, Yeon-Soon Ahn and Young Rok Seo
    Citation: Genes and Environment 2021 43:13
    Content type: Review Published on:

  30. A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings. Recent technological developments have f...

    Authors: Ippei Ohnishi, Yuji Iwashita, Yuto Matsushita, Shunsuke Ohtsuka, Takashi Yamashita, Keisuke Inaba, Atsuko Fukazawa, Hideto Ochiai, Keigo Matsumoto, Nobuhito Kurono, Yoshitaka Matsushima, Hiroki Mori, Shioto Suzuki, Shohachi Suzuki, Fumihiko Tanioka and Haruhiko Sugimura
    Citation: Genes and Environment 2021 43:12
    Content type: Research Published on:

  31. The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue. The comet assay of hepatocytes is well established; however, t...

    Authors: Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono and Masaaki Kurata
    Citation: Genes and Environment 2021 43:11
    Content type: Research Published on:

  32. The PIGRET assay is one of the Pig-a assays targeting reticulocytes (RETs), an in vivo genotoxicity evaluation method using flow cytometry with endogenous reporter glycosylphosphatidylinositol anchor protein. The...

    Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata
    Citation: Genes and Environment 2021 43:10
    Content type: Method Published on:

  33. Radio-adaptive response (RAR) is transient phenomena, where cells conditioned with a small dose (priming) of ionizing radiation shows significantly reduced DNA damage with a subsequent high challenging dose. T...

    Authors: Shridevi Shelke and Birajalaxmi Das
    Citation: Genes and Environment 2021 43:9
    Content type: Research Published on:

  35. Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagen...

    Authors: Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura…
    Citation: Genes and Environment 2021 43:7
    Content type: Research Published on:

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Marzieh Siavashifar, Fatemeh Rezaei, Tahereh Motallebirad, Davood Azadi, Abdorrahim Absalan, Zahra Naserramezani, Mohadeseh Golshani, Morteza Jafarinia and Kazem Ghaffari
    Citation: Genes and Environment 2021 43:6
    Content type: Correction Published on:

    The original article was published in Genes and Environment 2021 43:2

  38. Acrylamide (AA) is a rodent carcinogen and classified by the IARC into Group 2A (probable human carcinogen). AA has been reported to induce mutations in transgenic rodent gene mutation assays (TGR assays), the...

    Authors: Soichiro Hagio, Naho Tsuji, Satoshi Furukawa, Kazuya Takeuchi, Seigo Hayashi, Yusuke Kuroda, Masamitsu Honma and Kenichi Masumura
    Citation: Genes and Environment 2021 43:4
    Content type: Research Published on:

  39. There are very few studies covering the epidemiological risk factors associated with Epstein Barr Virus (EBV) and Microsatellite stability for Gastric Cancer (GC) cases. Early diagnosis of GC through epidemiologi...

    Authors: Payel Chakraborty, Souvik Ghatak, Saia Chenkual, Lalawmpuii Pachuau, John Zohmingthanga, Zothankima Bawihtlung, Lalfakzuala Khenglawt, Jeremy L. Pautu, Arindam Maitra, Lalchhandama Chhakchhuak and Nachimuthu Senthil Kumar
    Citation: Genes and Environment 2021 43:3
    Content type: Research Published on:

  40. Hospital environmental resources have a significant role in cross-transmission of opportunistic pathogens such as actinomycetes species to the patients. Actinomycetes have a remarkable capability to survive in...

    Authors: Marzieh Siavashifar, Fatemeh Rezaei, Tahereh Motallebirad, Davood Azadi, Abdorrahim Absalan, Zahra Naserramezani, Mohadeseh Golshani, Morteza Jafarinia and Kazem Ghaffari
    Citation: Genes and Environment 2021 43:2
    Content type: Research Published on:

    The Correction to this article has been published in Genes and Environment 2021 43:6

  41. Coronary Artery Disease (CAD) is caused by the blockage of the coronary arteries. it is argued that there has an association between the Interleukin-6 gene and the occurrence of atherosclerosis, coronary arter...

    Authors: Nader Salari, Kamran Mansouri, Amin Hosseinian-Far, Hooman Ghasemi, Masoud Mohammadi, Rostam Jalali and Aliakbar Vaisi-Raygani
    Citation: Genes and Environment 2021 43:1
    Content type: Research Published on:

  43. (Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies. We evalu...

    Authors: Masamitsu Honma, Airi Kitazawa, Toshio Kasamatsu and Kei-ichi Sugiyama
    Citation: Genes and Environment 2020 42:32
    Content type: Research Published on:

  44. The 6th Asian Congress on Environmental Mutagens (ACEM) was held at Hitotsubashi Hall, Chiyoda City, Tokyo on November 18–20, 2019, in conjunction with the 48th Annual Meeting of the Japanese Environmental Mut...

    Authors: Masamitsu Honma
    Citation: Genes and Environment 2020 42:30
    Content type: Meeting report Published on:

  45. DNA damage is generated by various intrinsic and extrinsic sources such as reactive oxygen species (ROS) and environmental mutagens, and causes genomic alterations. DNA damage response (DDR) is activated to in...

    Authors: Ako Matsui, Kazunari Hashiguchi, Masao Suzuki and Qiu-Mei Zhang-Akiyama
    Citation: Genes and Environment 2020 42:29
    Content type: Short report Published on:

  47. The use of in silico predictions for the assessment of bacterial mutagenicity under the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline is...

    Authors: Robert S. Foster, Adrian Fowkes, Alex Cayley, Andrew Thresher, Anne-Laure D. Werner, Chris G. Barber, Grace Kocks, Rachael E. Tennant, Richard V. Williams, Steven Kane and Susanne A. Stalford
    Citation: Genes and Environment 2020 42:27
    Content type: Short report Published on:

  48. Urinary nicotine and cotinine levels are often measured as biomarkers for tobacco smoke exposure. However, these biomarkers are not appropriate to evaluate the effects of quitting smoking for several days, bec...

    Authors: Yuya Kawasaki, Yun-Shan Li, Yuko Ootsuyama, Kazuhiko Nagata, Hiroshi Yamato and Kazuaki Kawai
    Citation: Genes and Environment 2020 42:26
    Content type: Research Published on:

  49. Hydroxychloroquine (HCQ) and Chloroquine (CQ) are two anti-malarial drugs that are now being extensively used by front-line healthcare workers and other common people as a prophylactic drug against the Corona ...

    Authors: Allan Giri, Ankita Das, Ajoy K. Sarkar and Ashok K. Giri
    Citation: Genes and Environment 2020 42:25
    Content type: Review Published on:

  50. Melanoma Antigen Genes (MAGEs) are a family of genes that have piqued the interest of scientists for their unique expression pattern. A subset of MAGEs (Type I) are expressed in spermatogonial cells and in no ...

    Authors: Ashley Colemon, Taylor M. Harris and Saumya Ramanathan
    Citation: Genes and Environment 2020 42:24
    Content type: Research Published on:

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