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  1. Translesion synthesis (TLS) is an error-prone pathway required to overcome replication blockage by DNA damage. Aberrant activation of TLS has been suggested to play a role in tumorigenesis by promoting genetic...

    Authors: Megumi Sasatani, Elena Karamfilova Zaharieva and Kenji Kamiya
    Citation: Genes and Environment 2020 42:9
  2. Next Generation Sequencer (NGS) is a powerful tool for a high-throughput sequencing of human genome. It is important to ensure reliability and sensitivity of the sequence data for a clinical use of the NGS. Va...

    Authors: Takayoshi Suzuki, Yoshinori Tsukumo, Chie Furihata, Mikihiko Naito and Arihiro Kohara
    Citation: Genes and Environment 2020 42:8
  3. A variety of in vivo and in vitro studies to assess the genotoxicity of titanium dioxide nanoparticles (TiO2 NPs) have been reported, but the results are inconsistent. Recently, we reported that TiO2 NPs exhibit ...

    Authors: Tetsuya Suzuki, Nobuhiko Miura, Rieko Hojo, Yukie Yanagiba, Megumi Suda, Tatsuya Hasegawa, Muneyuki Miyagawa and Rui-Sheng Wang
    Citation: Genes and Environment 2020 42:7

    The Correction to this article has been published in Genes and Environment 2020 42:10

  4. There is increasing evidence indicating an incidence of infertility and also the risk of endometrial cancers among smokers. However, the mechanism underlying nicotine adverse effect on female reproduction rema...

    Authors: Fatemeh Zal, Amir Yarahmadi, Hamidreza Totonchi, Mahdi Barazesh and Mostafa Moradi Sarabi
    Citation: Genes and Environment 2020 42:6
  5. Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards and modes of action for chemical toxicology. In ge...

    Authors: Julie K. Buick, Andrew Williams, Rémi Gagné, Carol D. Swartz, Leslie Recio, Stephen S. Ferguson and Carole L. Yauk
    Citation: Genes and Environment 2020 42:5
  6. It has yet to be determined whether or not the probability of developing cancer due to radiation exposure levels of low doses is proportional to the dose. Herein, for radiation hormesis occurring at low doses,...

    Authors: Katsuhito Kino
    Citation: Genes and Environment 2020 42:4
  7. Acetone is a common alternative solvent used in the Ames test when test chemicals are unstable or poorly soluble in water or dimethyl sulfoxide (DMSO). Yet, there is a very limited number of studies evaluating...

    Authors: Tomomi Shibata, Takeshi Yamagata, Akihiro Kawade, Shoji Asakura, Naoki Toritsuka, Naoki Koyama and Atsushi Hakura
    Citation: Genes and Environment 2020 42:3
  8. Acetaldehyde, produced upon exposure to alcohol, cigarette smoke, polluted air and sugar, is a highly reactive compound that is carcinogenic to humans and causes a variety of DNA lesions in living human cells....

    Authors: Haruka Tsuruta, Yuina Sonohara, Kosuke Tohashi, Narumi Aoki Shioi, Shigenori Iwai and Isao Kuraoka
    Citation: Genes and Environment 2020 42:2
  9. Surface waters receive a variety of organic pollutants via wastewater discharge, and sediment represents a sink for hydrophobic contaminants. In this study, we used in vitro yeast-based reporter gene assays an...

    Authors: Pei-Hsin Chou, Chien-Hsun Chen, Kuang-Yu Chen, Fung-Chi Ko, Tsung-Ya Tsai and Yi-Po Yeh
    Citation: Genes and Environment 2019 41:24
  10. Development of chemotherapeutic/preventive drugs that selectively kill cancer - the Holy Grail of cancer research - is a major challenge. A particular difficulty arises when chemotherapeutics and radiation are...

    Authors: John R. Ridpath and Jun Nakamura
    Citation: Genes and Environment 2019 41:23
  11. An extract from Spatholobus suberectus (S. suberectus) Dunn has been reported to show potent antimutagenic effects against N-alkyl-N-nitrosoureas in umu screening. The aim of this study was to identify the antimu...

    Authors: Keiko Inami, Yoshihisa Asada, Takumi Harada, Yuta Okayama, Noriko Usui and Masataka Mochizuki
    Citation: Genes and Environment 2019 41:22
  12. During the process of acclimatization, when our organism needs to adjust several metabolic processes in the attempt of establishing a better oxygenation, it is normal that individuals present some symptoms tha...

    Authors: Ricardo Muller Bottura, Giscard Humberto Oliveira Lima, Debora Cristina Hipolide and João Bosco Pesquero
    Citation: Genes and Environment 2019 41:18
  13. The open symposium of the Japanese Environmental Mutagen Society (JEMS), under the title of “Comprehensive framework between environment and genomic stability,” was held in the Main Conference Room of the Foun...

    Authors: Katsuyoshi Horibata, Masashi Sekimoto and Kei-ichi Sugiyama
    Citation: Genes and Environment 2019 41:17
  14. Diagnostic and therapeutic ionizing radiation (IR) is one of the well known long term risk factors of breast cancer. Extremely lethal consequences of IR causes double-strand breaks, which are mainly responsibl...

    Authors: Gugalavath Shailender, Seema Kumari, Patnala Kiranmayi and Rama Rao Malla
    Citation: Genes and Environment 2019 41:16
  15. The human genome is constantly exposed to numerous environmental genotoxicants. To prevent the detrimental consequences induced by the expansion of damaged cells, cellular protective systems such as nucleotide...

    Authors: Akira Sassa, Takayuki Fukuda, Akiko Ukai, Maki Nakamura, Michihito Takabe, Takeji Takamura-Enya, Masamitsu Honma and Manabu Yasui
    Citation: Genes and Environment 2019 41:15
  16. Frustrated phagocytosis occurs when an asbestos fiber > 10 μm in length is engulfed imperfectly by a macrophage, and it is believed to be associated with chromosomal instability. Few studies have focused on dy...

    Authors: Takenori Ishida, Nobutoshi Fujihara, Tomoki Nishimura, Hisakage Funabashi, Ryuichi Hirota, Takeshi Ikeda and Akio Kuroda
    Citation: Genes and Environment 2019 41:14
  17. The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. I...

    Authors: Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita and Makoto Hayashi
    Citation: Genes and Environment 2019 41:13
  18. The MucA’ and MucB proteins comprise the core of DNA polymerase RI which is a strong mutator utilized in mutagenicity assays such as the standard Ames test. A close relative DNA polymerase V, composed of the h...

    Authors: Petr Grúz, Kei-ichi Sugiyama, Masamitsu Honma and Takehiko Nohmi
    Citation: Genes and Environment 2019 41:10
  19. In the original publication of this article [1], the author pointed out the reference list mismatched citations in the main text. All citations and reference has been updated.

    Authors: Shizuyo Sutou
    Citation: Genes and Environment 2019 41:12

    The original article was published in Genes and Environment 2018 40:26

  20. Chloroethylnitrosourea (CENU) derivatives, such as nimustine (ACNU) and carmustine (BCNU), are employed in brain tumor chemotherapy due to their ability to cross the blood-brain barrier. They are thought to su...

    Authors: Yoko Yamada, Shinji Watanabe, Keinosuke Okamoto, Sakae Arimoto, Eizo Takahashi, Kazuo Negishi and Tomoe Negishi
    Citation: Genes and Environment 2019 41:11
  21. The harmful effects of fine particles with an aerodynamic diameter less than 2.5 μm (PM2.5) on respiratory organs are emphasized in pollution studies because PM2.5 have high deposition rates in the respiratory...

    Authors: Kazutoshi Sugita, Yuka Kin, Mayuko Yagishita, Fumikazu Ikemori, Kimiyo Kumagai, Toshihiko Ohara, Makoto Kinoshita, Kazuyuki Nishimura, Yukihiko Takagi and Daisuke Nakajima
    Citation: Genes and Environment 2019 41:7
  22. The Pig-a assay, a promising tool for evaluating in vivo genotoxicity, is based on flow cytometric enumeration of red blood cells (RBCs) that are deficient in glycosylphosphatidylinositol anchor protein. Various ...

    Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata
    Citation: Genes and Environment 2019 41:5
  23. The in vitro micronucleus (MN) test is an important component of a genotoxicity test battery that evaluates chemicals. Although the standard method of manually scoring micronucleated (MNed) cells by microscope...

    Authors: Akira Takeiri, Kaori Matsuzaki, Shigeki Motoyama, Mariko Yano, Asako Harada, Chiaki Katoh, Kenji Tanaka and Masayuki Mishima
    Citation: Genes and Environment 2019 41:4
  24. Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the genome. In mammalian global genomic NER, the XPC protein complex initiates...

    Authors: Masayuki Kusakabe, Yuki Onishi, Haruto Tada, Fumika Kurihara, Kanako Kusao, Mari Furukawa, Shigenori Iwai, Masayuki Yokoi, Wataru Sakai and Kaoru Sugasawa
    Citation: Genes and Environment 2019 41:2
  25. Evidence from epidemiological and experimental studies has shown that the etiology of colorectal cancer (CRC) is related to lifestyle, mainly diet. At the same time, there are many foods and beverages that hav...

    Authors: Shuya Tamura, Takumi Narita, Gen Fujii, Shingo Miyamoto, Takahiro Hamoya, Yurie Kurokawa, Maiko Takahashi, Kouhei Miki, Yui Matsuzawa, Masami Komiya, Masaru Terasaki, Tomohiro Yano and Michihiro Mutoh
    Citation: Genes and Environment 2019 41:1
  26. The US National Academy of Sciences (NAS) presented the linear no-threshold hypothesis (LNT) in 1956, which indicates that the lowest doses of ionizing radiation are hazardous in proportion to the dose. This s...

    Authors: Shizuyo Sutou
    Citation: Genes and Environment 2018 40:26

    The Correction to this article has been published in Genes and Environment 2019 41:12

  27. Previously we found that DNA adducts were accumulated in the lungs of the rats exposed to ambient air in the Tokyo metropolitan area. To examine chronological change in in vivo mutagenicity of airborne particl...

    Authors: Yasunobu Aoki, Daisuke Nakajima, Michiyo Matsumoto, Mayuko Yagishita, Michi Matsumoto, Rie Yanagisawa, Sumio Goto, Kenichi Masumura and Takehiko Nohmi
    Citation: Genes and Environment 2018 40:25
  28. A wide variety of DNA lesions interfere with replication and transcription, leading to mutations and cell death. DNA repair mechanisms act upon these DNA lesions present in the genomic DNA. To investigate a DN...

    Authors: Mika Yukutake, Mika Hayashida, Narumi Shioi Aoki and Isao Kuraoka
    Citation: Genes and Environment 2018 40:23
  29. The Open Symposium of the Japanese Environmental Mutagen Society (JEMS) entitled “Challenges of Young Scientists at the Cutting-edge of Genotoxicity Research” was held in the Main Conference Room of the Founda...

    Authors: Manabu Yasui, Shigeharu Muto and Akira Sassa
    Citation: Genes and Environment 2018 40:22
  30. According to the linear no-threshold model (LNT), even the smallest amount of radiation is hazardous. Although the LNT is not based on solid data, this hypothesis has been applied to mutagens and carcinogens. ...

    Authors: Shizuyo Sutou, Akiko Koeda, Kana Komatsu, Toshiyuki Shiragiku, Hiroshi Seki, Kohji Yamakage, Takeru Niitsuma, Toshiyuki Kudo and Akihiro Wakata
    Citation: Genes and Environment 2018 40:20
  31. Use of Quantitative Structure-Activity Relationships ((Q)SAR) prediction tools has been increasing since the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use ...

    Authors: Masayuki Mishima, Tsuneo Hashizume, Yu Haranosono, Yusuke Nagato, Kentaro Takeshita, Junichi Fukuchi and Masamitsu Homma
    Citation: Genes and Environment 2018 40:19
  32. The carcinogenic potential of dimethylaniline (DMA) isomers in rodents and humans has been previously reported, and there is sufficient evidence for the carcinogenicity of 2,6-DMA in experimental animals. The ...

    Authors: Arihiro Kohara, Mariko Matsumoto, Akihiko Hirose, Makoto Hayashi, Masamitsu Honma and Takayoshi Suzuki
    Citation: Genes and Environment 2018 40:18
  33. Grx6 is a yeast Golgi/endoplasmic reticulum protein involved in iron-sulfur binding that belongs to monothiol glutaredoxin-protein family. Grx6 has been biochemically characterized previously. Grx6 contains a ...

    Authors: Mohnad Abdalla, Wafa Ali Eltayb, Amr Ahmed El-Arabey, Raihan Mo, T. I. M. Dafaalla, Hamed I. Hamouda, Eijaz Ahmed Bhat, Annoor Awadasseid and Hassan Abdellha Ahmed Ali
    Citation: Genes and Environment 2018 40:15
  34. Nucleoside triphosphates participate in fundamental cellular processes as building blocks of DNA and RNA, energy carriers, and cofactors in enzymatic reactions, and their balance is tightly regulated. Here, we...

    Authors: Shun Matsuda and Toshihiko Kasahara
    Citation: Genes and Environment 2018 40:13
  35. There is still considerable debate about the effects of exposure to bisphenol A (BPA) an endocrine disrupter at low doses. Recently, many studies using animal models have shown that prenatal BPA exposure induc...

    Authors: Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi and Seiichiroh Ohsako
    Citation: Genes and Environment 2018 40:12

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