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  1. Sex steroid hormone receptors are classified into three classes of receptors: estrogen receptors (ER) α and β, androgen receptor (AR), and progesterone receptor (PR). They belong to the nuclear receptor superf...

    Authors: Sayoko Ito-Harashima, Mami Matano, Kana Onishi, Tomofumi Nomura, Saki Nakajima, Shingo Ebata, Kazuhiro Shiizaki, Masanobu Kawanishi and Takashi Yagi
    Citation: Genes and Environment 2020 42:20
    Content type: Research Published on:

  2. DNA-dependent protein kinase (DNA-PK), consisting of a Ku heterodimer (Ku70/80) and a large catalytic subunit (DNA-PKcs), plays an important role in the repair of DNA double-strand breaks via non-homologous en...

    Authors: Kenichi Masumura, Fumio Yatagai, Masako Ochiai, Hitoshi Nakagama and Takehiko Nohmi
    Citation: Genes and Environment 2020 42:19
    Content type: Short report Published on:

  4. In the course of our research to investigate the cancer prevention potency of natural products derived from plant materials, we isolated fifty-five compounds, including twenty-one new compounds from the peels of

    Authors: Takahiro Matsumoto and Tetsushi Watanabe
    Citation: Genes and Environment 2020 42:17
    Content type: Review Published on:

  5. Kaolin is a clay mineral with the chemical composition Al2Si2O5(OH)4. It is an important industrial material, and is also used as a white cosmetic pigment. We previously reported that fine particles of kaolin hav...

    Authors: Masanobu Kawanishi, Reimi Yoneda, Yukari Totsuka and Takashi Yagi
    Citation: Genes and Environment 2020 42:16
    Content type: Short report Published on:

  6. Various challenges have been overcome with regard to applying ‘omics technologies for chemical risk assessments. Previously we published results detailing targeted mRNA sequencing (RNA-Seq) on a next generatio...

    Authors: Chie Furihata, Xinyue You, Takeshi Toyoda, Kumiko Ogawa and Takayoshi Suzuki
    Citation: Genes and Environment 2020 42:15
    Content type: Short report Published on:

  7. The standard Ames test strains owe their high sensitivity to chemical and physical mutagens to the episomal Y-family DNA polymerase RI encoded by the mucAB operon. The S. typhimurium test strains carry also anoth...

    Authors: Petr Grúz, Masatomi Shimizu, Kei-ichi Sugiyama, Masami Yamada and Masamitsu Honma
    Citation: Genes and Environment 2020 42:14
    Content type: Research Published on:

  8. The endocrine disruptor Bisphenol-A (BPA), has been involved in dysregulating adipose tissue development and increasing the risk of obesity. The objective of this experiment was to investigate whether treatmen...

    Authors: Amin Salehpour, Farzad Shidfar, Mehdi Hedayati, Asal Neshatbini Tehrani, Ali Asghar Farshad and Saeed Mohammadi
    Citation: Genes and Environment 2020 42:13
    Content type: Research Published on:

  9. Colibactin is a small genotoxic molecule produced by enteric bacteria, including certain Escherichia coli (E. coli) strains harbored in the human large intestine. This polyketide-peptide genotoxin is considered t...

    Authors: Masanobu Kawanishi, Chiaki Shimohara, Yoshimitsu Oda, Yuuta Hisatomi, Yuta Tsunematsu, Michio Sato, Yuichiro Hirayama, Noriyuki Miyoshi, Yuji Iwashita, Yuko Yoshikawa, Haruhiko Sugimura, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Takashi Yagi and Kenji Watanabe
    Citation: Genes and Environment 2020 42:12
    Content type: Short report Published on:

  11. In the original publication of this article [1], the author made a correction but wasn’t carried out.

    Authors: Tetsuya Suzuki, Nobuhiko Miura, Rieko Hojo, Yukie Yanagiba, Megumi Suda, Tatsuya Hasegawa, Muneyuki Miyagawa and Rui-Sheng Wang
    Citation: Genes and Environment 2020 42:10
    Content type: Correction Published on:

    The original article was published in Genes and Environment 2020 42:7

  12. Translesion synthesis (TLS) is an error-prone pathway required to overcome replication blockage by DNA damage. Aberrant activation of TLS has been suggested to play a role in tumorigenesis by promoting genetic...

    Authors: Megumi Sasatani, Elena Karamfilova Zaharieva and Kenji Kamiya
    Citation: Genes and Environment 2020 42:9
    Content type: Review Published on:

  13. Next Generation Sequencer (NGS) is a powerful tool for a high-throughput sequencing of human genome. It is important to ensure reliability and sensitivity of the sequence data for a clinical use of the NGS. Va...

    Authors: Takayoshi Suzuki, Yoshinori Tsukumo, Chie Furihata, Mikihiko Naito and Arihiro Kohara
    Citation: Genes and Environment 2020 42:8
    Content type: Short report Published on:

  14. A variety of in vivo and in vitro studies to assess the genotoxicity of titanium dioxide nanoparticles (TiO2 NPs) have been reported, but the results are inconsistent. Recently, we reported that TiO2 NPs exhibit ...

    Authors: Tetsuya Suzuki, Nobuhiko Miura, Rieko Hojo, Yukie Yanagiba, Megumi Suda, Tatsuya Hasegawa, Muneyuki Miyagawa and Rui-Sheng Wang
    Citation: Genes and Environment 2020 42:7
    Content type: Research Published on:

    The Correction to this article has been published in Genes and Environment 2020 42:10

  15. There is increasing evidence indicating an incidence of infertility and also the risk of endometrial cancers among smokers. However, the mechanism underlying nicotine adverse effect on female reproduction rema...

    Authors: Fatemeh Zal, Amir Yarahmadi, Hamidreza Totonchi, Mahdi Barazesh and Mostafa Moradi Sarabi
    Citation: Genes and Environment 2020 42:6
    Content type: Research Published on:

  16. Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards and modes of action for chemical toxicology. In ge...

    Authors: Julie K. Buick, Andrew Williams, Rémi Gagné, Carol D. Swartz, Leslie Recio, Stephen S. Ferguson and Carole L. Yauk
    Citation: Genes and Environment 2020 42:5
    Content type: Research Published on:

  17. It has yet to be determined whether or not the probability of developing cancer due to radiation exposure levels of low doses is proportional to the dose. Herein, for radiation hormesis occurring at low doses,...

    Authors: Katsuhito Kino
    Citation: Genes and Environment 2020 42:4
    Content type: Commentary Published on:

  18. Acetone is a common alternative solvent used in the Ames test when test chemicals are unstable or poorly soluble in water or dimethyl sulfoxide (DMSO). Yet, there is a very limited number of studies evaluating...

    Authors: Tomomi Shibata, Takeshi Yamagata, Akihiro Kawade, Shoji Asakura, Naoki Toritsuka, Naoki Koyama and Atsushi Hakura
    Citation: Genes and Environment 2020 42:3
    Content type: Research Published on:

  19. Acetaldehyde, produced upon exposure to alcohol, cigarette smoke, polluted air and sugar, is a highly reactive compound that is carcinogenic to humans and causes a variety of DNA lesions in living human cells....

    Authors: Haruka Tsuruta, Yuina Sonohara, Kosuke Tohashi, Narumi Aoki Shioi, Shigenori Iwai and Isao Kuraoka
    Citation: Genes and Environment 2020 42:2
    Content type: Research Published on:

  21. Surface waters receive a variety of organic pollutants via wastewater discharge, and sediment represents a sink for hydrophobic contaminants. In this study, we used in vitro yeast-based reporter gene assays an...

    Authors: Pei-Hsin Chou, Chien-Hsun Chen, Kuang-Yu Chen, Fung-Chi Ko, Tsung-Ya Tsai and Yi-Po Yeh
    Citation: Genes and Environment 2019 41:24
    Content type: Research Published on:

  22. Development of chemotherapeutic/preventive drugs that selectively kill cancer - the Holy Grail of cancer research - is a major challenge. A particular difficulty arises when chemotherapeutics and radiation are...

    Authors: John R. Ridpath and Jun Nakamura
    Citation: Genes and Environment 2019 41:23
    Content type: Short report Published on:

  23. An extract from Spatholobus suberectus (S. suberectus) Dunn has been reported to show potent antimutagenic effects against N-alkyl-N-nitrosoureas in umu screening. The aim of this study was to identify the antimu...

    Authors: Keiko Inami, Yoshihisa Asada, Takumi Harada, Yuta Okayama, Noriko Usui and Masataka Mochizuki
    Citation: Genes and Environment 2019 41:22
    Content type: Research Published on:

  26. During the process of acclimatization, when our organism needs to adjust several metabolic processes in the attempt of establishing a better oxygenation, it is normal that individuals present some symptoms tha...

    Authors: Ricardo Muller Bottura, Giscard Humberto Oliveira Lima, Debora Cristina Hipolide and João Bosco Pesquero
    Citation: Genes and Environment 2019 41:18
    Content type: Research Published on:

  28. The open symposium of the Japanese Environmental Mutagen Society (JEMS), under the title of “Comprehensive framework between environment and genomic stability,” was held in the Main Conference Room of the Foun...

    Authors: Katsuyoshi Horibata, Masashi Sekimoto and Kei-ichi Sugiyama
    Citation: Genes and Environment 2019 41:17
    Content type: Meeting report Published on:

  29. Diagnostic and therapeutic ionizing radiation (IR) is one of the well known long term risk factors of breast cancer. Extremely lethal consequences of IR causes double-strand breaks, which are mainly responsibl...

    Authors: Gugalavath Shailender, Seema Kumari, Patnala Kiranmayi and Rama Rao Malla
    Citation: Genes and Environment 2019 41:16
    Content type: Short report Published on:

  30. The human genome is constantly exposed to numerous environmental genotoxicants. To prevent the detrimental consequences induced by the expansion of damaged cells, cellular protective systems such as nucleotide...

    Authors: Akira Sassa, Takayuki Fukuda, Akiko Ukai, Maki Nakamura, Michihito Takabe, Takeji Takamura-Enya, Masamitsu Honma and Manabu Yasui
    Citation: Genes and Environment 2019 41:15
    Content type: Research Published on:

  31. Frustrated phagocytosis occurs when an asbestos fiber > 10 μm in length is engulfed imperfectly by a macrophage, and it is believed to be associated with chromosomal instability. Few studies have focused on dy...

    Authors: Takenori Ishida, Nobutoshi Fujihara, Tomoki Nishimura, Hisakage Funabashi, Ryuichi Hirota, Takeshi Ikeda and Akio Kuroda
    Citation: Genes and Environment 2019 41:14
    Content type: Research Published on:

  32. The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. I...

    Authors: Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita and Makoto Hayashi
    Citation: Genes and Environment 2019 41:13
    Content type: Research Published on:

  33. The MucA’ and MucB proteins comprise the core of DNA polymerase RI which is a strong mutator utilized in mutagenicity assays such as the standard Ames test. A close relative DNA polymerase V, composed of the h...

    Authors: Petr Grúz, Kei-ichi Sugiyama, Masamitsu Honma and Takehiko Nohmi
    Citation: Genes and Environment 2019 41:10
    Content type: Research Published on:

  34. In the original publication of this article [1], the author pointed out the reference list mismatched citations in the main text. All citations and reference has been updated.

    Authors: Shizuyo Sutou
    Citation: Genes and Environment 2019 41:12
    Content type: Correction Published on:

    The original article was published in Genes and Environment 2018 40:26

  35. Chloroethylnitrosourea (CENU) derivatives, such as nimustine (ACNU) and carmustine (BCNU), are employed in brain tumor chemotherapy due to their ability to cross the blood-brain barrier. They are thought to su...

    Authors: Yoko Yamada, Shinji Watanabe, Keinosuke Okamoto, Sakae Arimoto, Eizo Takahashi, Kazuo Negishi and Tomoe Negishi
    Citation: Genes and Environment 2019 41:11
    Content type: Research Published on:

  39. The harmful effects of fine particles with an aerodynamic diameter less than 2.5 μm (PM2.5) on respiratory organs are emphasized in pollution studies because PM2.5 have high deposition rates in the respiratory...

    Authors: Kazutoshi Sugita, Yuka Kin, Mayuko Yagishita, Fumikazu Ikemori, Kimiyo Kumagai, Toshihiko Ohara, Makoto Kinoshita, Kazuyuki Nishimura, Yukihiko Takagi and Daisuke Nakajima
    Citation: Genes and Environment 2019 41:7
    Content type: Research Published on:

  40. The Pig-a assay, a promising tool for evaluating in vivo genotoxicity, is based on flow cytometric enumeration of red blood cells (RBCs) that are deficient in glycosylphosphatidylinositol anchor protein. Various ...

    Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata
    Citation: Genes and Environment 2019 41:5
    Content type: Method Published on:

  41. The in vitro micronucleus (MN) test is an important component of a genotoxicity test battery that evaluates chemicals. Although the standard method of manually scoring micronucleated (MNed) cells by microscope...

    Authors: Akira Takeiri, Kaori Matsuzaki, Shigeki Motoyama, Mariko Yano, Asako Harada, Chiaki Katoh, Kenji Tanaka and Masayuki Mishima
    Citation: Genes and Environment 2019 41:4
    Content type: Research Published on:

  43. Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the genome. In mammalian global genomic NER, the XPC protein complex initiates...

    Authors: Masayuki Kusakabe, Yuki Onishi, Haruto Tada, Fumika Kurihara, Kanako Kusao, Mari Furukawa, Shigenori Iwai, Masayuki Yokoi, Wataru Sakai and Kaoru Sugasawa
    Citation: Genes and Environment 2019 41:2
    Content type: Review Published on:

  44. Evidence from epidemiological and experimental studies has shown that the etiology of colorectal cancer (CRC) is related to lifestyle, mainly diet. At the same time, there are many foods and beverages that hav...

    Authors: Shuya Tamura, Takumi Narita, Gen Fujii, Shingo Miyamoto, Takahiro Hamoya, Yurie Kurokawa, Maiko Takahashi, Kouhei Miki, Yui Matsuzawa, Masami Komiya, Masaru Terasaki, Tomohiro Yano and Michihiro Mutoh
    Citation: Genes and Environment 2019 41:1
    Content type: Research Published on:

  46. The US National Academy of Sciences (NAS) presented the linear no-threshold hypothesis (LNT) in 1956, which indicates that the lowest doses of ionizing radiation are hazardous in proportion to the dose. This s...

    Authors: Shizuyo Sutou
    Citation: Genes and Environment 2018 40:26
    Content type: Commentary Published on:

    The Correction to this article has been published in Genes and Environment 2019 41:12

  47. Previously we found that DNA adducts were accumulated in the lungs of the rats exposed to ambient air in the Tokyo metropolitan area. To examine chronological change in in vivo mutagenicity of airborne particl...

    Authors: Yasunobu Aoki, Daisuke Nakajima, Michiyo Matsumoto, Mayuko Yagishita, Michi Matsumoto, Rie Yanagisawa, Sumio Goto, Kenichi Masumura and Takehiko Nohmi
    Citation: Genes and Environment 2018 40:25
    Content type: Research Published on:

  48. A wide variety of DNA lesions interfere with replication and transcription, leading to mutations and cell death. DNA repair mechanisms act upon these DNA lesions present in the genomic DNA. To investigate a DN...

    Authors: Mika Yukutake, Mika Hayashida, Narumi Shioi Aoki and Isao Kuraoka
    Citation: Genes and Environment 2018 40:23
    Content type: Research Published on:

  49. The Open Symposium of the Japanese Environmental Mutagen Society (JEMS) entitled “Challenges of Young Scientists at the Cutting-edge of Genotoxicity Research” was held in the Main Conference Room of the Founda...

    Authors: Manabu Yasui, Shigeharu Muto and Akira Sassa
    Citation: Genes and Environment 2018 40:22
    Content type: Meeting report Published on:

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