Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).
Articles
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Citation: Genes and Environment 2024 46:9
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The spectrum of TP53 mutations in Rwandan patients with gastric cancer
Gastric cancer is the sixth most frequently diagnosed cancer and third in causing cancer-related death globally. The most frequently mutated gene in human cancers is TP53, which plays a pivotal role in cancer ini...
Citation: Genes and Environment 2024 46:8 -
Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice
Carbendazim (methyl 2-benzimidazolecarbamate, CASRN: 10605-21-7) exhibits spindle poisoning effects and is widely used as a fungicide. With respect to genotoxicity, carbendazim is deemed to be non-mutagenic in...
Citation: Genes and Environment 2024 46:7 -
Correction: NCAPD2 is a favorable predictor of prognostic and immunotherapeutic biomarker for multiple cancer types including lung cancer
Citation: Genes and Environment 2024 46:6 -
Understanding exposomes and its relation with cancer risk in Malaysia based on epidemiological evidence: a narrative review
The prevalence of cancer is increasing globally, and Malaysia is no exception. The exposome represents a paradigm shift in cancer research, emphasizing the importance of a holistic approach that considers the ...
Citation: Genes and Environment 2024 46:5 -
Curcumin piperidone derivatives induce caspase-dependent apoptosis and suppress miRNA-21 expression in LN-18 human glioblastoma cells
Previously, we have reported on the two curcuminoid analogues with piperidone derivatives, namely FLDP-5 and FLDP-8 have more potent anti-proliferative and anti-migration effects than curcumin. In this study, ...
Citation: Genes and Environment 2024 46:4 -
CDK4/6 inhibitor-induced bone marrow micronuclei might be caused by cell cycle arrest during erythropoiesis
A micronucleus test is generally used to evaluate the genotoxic potential of chemicals. Exaggerated erythropoiesis, as occurs following bleeding, may induce an unexpected increase in micronucleus frequency. Th...
Citation: Genes and Environment 2024 46:3 -
NCAPD2 is a favorable predictor of prognostic and immunotherapeutic biomarker for multiple cancer types including lung cancer
Non-SMC condensin I complex subunit D2 (NCAPD2) belongs to the chromosomal structural maintenance family. While the different contribution of NCAPD2 to chromosome in mitosis have been thoroughly investigated, ...
Citation: Genes and Environment 2024 46:2 -
Metformin suppresses proliferation and glycolysis of gastric cancer by modulating ADAMTS12
Gastric cancer (GC) is a common malignancy with its morbidity increasing worldwide. Hence, it is imperative to develop effective treatments. Studies have shown that metformin has potential antitumor effects. T...
Citation: Genes and Environment 2024 46:1 -
Selenium biofortification improves bioactive composition and antioxidant status in Plantago ovata Forsk., a medicinal plant
Selenium (Se) is an essential micronutrient for humans, but its deficiency as well as toxicity affects large number of people worldwide. Plantago ovata, a commercially important medicinal plant, is mainly cultiva...
Citation: Genes and Environment 2023 45:38 -
Absolute quantification of DNA damage response proteins
DNA damage response (DDR) and repair are vital for safeguarding genetic information and ensuring the survival and accurate transmission of genetic material. DNA damage, such as DNA double-strand breaks (DSBs),...
Citation: Genes and Environment 2023 45:37 -
Considerations for the genotoxicity assessment of middle size peptide drugs containing non-canonical amino acid residues
Middle size peptides (MSPs) have emerged as a promising new pharmaceutical modality. We are seeking the best way to assess the non-clinical safety of MSPs.
Citation: Genes and Environment 2023 45:36 -
Current status and challenges of breast cancer prevention~DNA methylation would lead to groundbreaking progress in breast cancer prevention~
The number of breast cancer patients is increasing worldwide. Furthermore, breast cancer often develops in young people, even those only in their 30s, who play a central role in their families and society. Res...
Citation: Genes and Environment 2023 45:35 -
The Malaysian Society of Toxicology: from establishment to evolution, a promising future!
The Malaysian Society of Toxicology (MySOT), founded in 2010, emerged as a response to the growing need for a collective and interdisciplinary effort to study the effects of substances on human health, and the...
Citation: Genes and Environment 2023 45:34 -
Carcinogenic risk of food additive AF-2 banned in Japan: a case study on reassessment of genotoxicity
Carcinogenic risk assessment studies have been repeatedly improved and are still being debated to find a goal. Evaluation might be changed if new approaches would be applied to some chemicals which means that ...
Citation: Genes and Environment 2023 45:33 -
Detection of EGFR gene polymorphisms in non-small cell lung cancer Egyptian patients: a case–control study
Non-Small Cell Lung Cancer displays several genetic mutations including epidermal growth factor receptor. This study's objective was to determine if the EGFR exon19 rs121913438 and exon21 rs121434568 variation...
Citation: Genes and Environment 2023 45:32 -
Risk assessment of aflatoxin B1 in herbal medicines and plant food supplements marketed in Malaysia using margin of exposure and RISK21 approaches
Aflatoxin B1 (AFB1) is a mycotoxin produced by several species of Aspergillus fungi which can cause liver cancer in animals and humans. This study aims to perform the risk assessment of AFB1 in herbal medicines a...
Citation: Genes and Environment 2023 45:31 -
Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques
Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic en...
Citation: Genes and Environment 2023 45:30 -
In vivo mutagenicity assessment of orally treated tert-butyl hydroperoxide in the liver and glandular stomach of MutaMouse
tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester. It is a high-production chemical...
Citation: Genes and Environment 2023 45:29 -
Genoprotective potential of Macaranga species phytochemical compounds on HT-29 human colorectal adenocarcinoma cell line
The species of genus Macaranga are widely found in Malaysian secondary forests and has been used as an alternative for treating varieties of illness. Studies have shown that the medicinal properties of this genus...
Citation: Genes and Environment 2023 45:28 -
Formation of the mutagenic DNA lesion 1,N2-ethenoguanine induced by heated cooking oil and identification of causative agents
The DNA-damaging compounds in heated cooking oil were identified as guanosine adducts. Heated vegetable oil was subjected to deep-frying conditions at 170 °C for 45 min, reacted with isopropylidene guanosine (...
Citation: Genes and Environment 2023 45:27 -
Genetic characteristics of spouse selection based on short tandem repeats in DNA and lunula count on fingertip
The aim of this study was to assess the correlation of spouse selection with short tandem repeats (STRs) in DNA and with the number of fingertip lunulae to investigate the role of heredity in spouse selection.
Citation: Genes and Environment 2023 45:26 -
Association of PSA variability with prostate cancer development using large-scale medical information data: a retrospective cohort study
Prostate cancer is one of the most common cancers among men worldwide and the fourth most common cause of death. The number of prostate cancer cases and deaths is increasing every year because of population ag...
Citation: Genes and Environment 2023 45:25 -
LncRNA PVT1 induces apoptosis and inflammatory response of bronchial epithelial cells by regulating miR-30b-5p/BCL2L11 axis in COPD
Chronic obstructive pulmonary disease (COPD) is a serious health burden worldwide with high mortality. LncRNA plasmacytoma variant translocation 1 (PVT1) has been illustrated to serve as a biomarker for COPD p...
Citation: Genes and Environment 2023 45:24 -
M6A transcriptome-wide map of circRNAs identified in the testis of normal and AZ-treated Xenopus laevis
Evidence showed that N6-methyladenosine (m6A) is strongly associated with male germline development. However, the role of m6A methylation on circRNAs in amphibians remains unknown. In this study, we conducted m6A...
Citation: Genes and Environment 2023 45:23 -
Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms
Understanding of metabolic processes is a key factor to evaluate biological effects of carcinogen and mutagens. Applicability of fused-grid Template* systems of CYP enzymes (Drug Metab Pharmacokinet 2019, 2020...
Citation: Genes and Environment 2023 45:22 -
Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced D...
Citation: Genes and Environment 2023 45:21 -
TP53 mutations in Romanian patients with colorectal cancer
Colorectal cancer (CRC) has been ranked as the second most deadly cancer and the third most diagnosed cancer cases for the year 2020. Specifically for Romania, the number of CRC-related deaths in 2019 was esti...
Citation: Genes and Environment 2023 45:20 -
Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice
We investigated the chemopreventive effects of beer, nonalcoholic beers (NABs), and beer-components (glycine betaine (GB)) on NNK-induced lung tumorigenesis in A/J mice, and the possible mechanisms underlying ...
Citation: Genes and Environment 2023 45:19 -
Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy
Helicobacter pylori secretes cytotoxin-associated gene A (CagA) into the gastric epithelium, causing gastric mucosal atrophy (GMA) and gastric cancer. In contrast, host cells degrade CagA via autophagy. However, ...
Citation: Genes and Environment 2023 45:18 -
Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle
Environmental heat stress in dairy cattle leads to poor health, reduced milk production and decreased reproductive efficiency. Multiple genes interact and coordinate the response to overcome the impact of heat...
Citation: Genes and Environment 2023 45:17 -
Non-linear dose response of DNA double strand breaks in response to chronic low dose radiation in individuals from high level natural radiation areas of Kerala coast
The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects of low dose and low dose rate ionizing radiation below 10...
Citation: Genes and Environment 2023 45:16 -
DNA polymerase Îş suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice
Chronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase Îş (Pol Îş), involved in translesion DNA synthesis, counteracts mutagenesis induced ...
Citation: Genes and Environment 2023 45:15 -
Development of a micronucleus test using the EpiAirway™ organotypic human airway model
The use of organotypic human tissue models in genotoxicity has increased as an alternative to animal testing. Genotoxicity is generally examined using a battery of in vitro assays such as Ames and micronucleus...
Citation: Genes and Environment 2023 45:14 -
The H2TH-like motif of the Escherichia coli multifunctional protein KsgA is required for DNA binding involved in DNA repair and the suppression of mutation frequencies
DNA oxidatively damaged by reactive oxygen species is repaired by base excision repair (BER) pathway proteins, with DNA glycosylases removing damaged or mismatched bases in the first step of BER. KsgA is a mul...
Citation: Genes and Environment 2023 45:13 -
In vivo mutagenicity assessment of styrene in MutaMouse liver and lung
Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a smal...
Citation: Genes and Environment 2023 45:12 -
Mutation and apoptosis are well-coordinated for protecting against DNA damage-inducing toxicity in Drosophila
Apoptotic cell death is an important survival system for multicellular organisms because it removes damaged cells. Mutation is also a survival method for dealing with damaged cells in multicellular and also un...
Citation: Genes and Environment 2023 45:11 -
Exposure to environmental chemicals and cancer risk: epidemiological evidence from Japanese studies
Exposure to certain chemicals in the environment may contribute to the risk of developing cancer. Although cancer risk from environmental chemical exposure among general populations is considered low compared ...
Citation: Genes and Environment 2023 45:10 -
Analytical technologies to revolutionize the environmental mutagenesis-and genome- research -from the basics to the cutting-edge research-: the Open Symposium of the Japanese Environmental Mutagen and Genome Society (JEMS), 2022
The Open Symposium of the Japanese Environmental Mutagen and Genome Society (JEMS) entitled “Analytical technologies to revolutionize the environmental mutagenesis and genome research -From the basics to the c...
Citation: Genes and Environment 2023 45:9 -
Screening method toward ClbP-specific inhibitors
Colibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal cancer (CRC) of their symbiosis hosts, including human. A peptidase ClbP is ...
Citation: Genes and Environment 2023 45:8 -
Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR
Next-generation RNA sequencing (RNA-Seq) has identified more differentially expressed protein-coding genes (DEGs) and provided a wider quantitative range of expression level changes than conventional DNA micro...
Citation: Genes and Environment 2023 45:7 -
Report of the online meeting of the 7th Asian Conference on Environmental Mutagens (ACEM), China, November 5-6, 2022
The 7th Asian Conference on Environmental Mutagens (ACEM 2022) was held online from November 5–6, 2022. However, the 19th Chinese Environmental Mutagen Society Meeting was postponed due to the pandemic prevent...
Citation: Genes and Environment 2023 45:6 -
Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell
Heat shock proteins (Hsps) are overexpressed in several tumors and contribute to cell proliferation, metastasis, and anticancer drug resistance. Therefore, Hsp inhibitors have enhanced cytotoxicity as chemothe...
Citation: Genes and Environment 2023 45:5 -
Micronucleus test using formalin-fixed rat glandular stomach and colon
Genotoxicity in tissues other than hematopoietic tissues, such as the liver and gastrointestinal (GI) tract, is an important focus in the risk assessment of chemicals in humans. We previously developed a rat m...
Citation: Genes and Environment 2023 45:4 -
Effects of plasma-activated Ringer’s lactate solution on cancer cells: evaluation of genotoxicity
Non-thermal atmospheric pressure plasma technologies form the core of many scientific advances, including in the electronic, industrial, and biotechnological fields. The use of plasma as a cancer therapy has r...
Citation: Genes and Environment 2023 45:3 -
Environmental impact on carcinogenesis under BRCA1 haploinsufficiency
Cancer is the primary cause of human mortality in Japan since 1981. Although numerous novel therapies have been developed and applied in clinics, the number of deaths from cancer is still increasing worldwide....
Citation: Genes and Environment 2023 45:2 -
Non-CpG sites preference in G:C > A:T transition of TP53 in gastric cancer of Eastern Europe (Poland, Romania and Hungary) compared to East Asian countries (China and Japan)
Mutation spectrum of TP53 in gastric cancer (GC) has been investigated world-widely, but a comparison of mutation spectrum among GCs from various regions in the world are still sparsely documented. In order to id...
Citation: Genes and Environment 2023 45:1 -
Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse
Previously, we reported the inhibitory effect of Actinidia arguta juice, known as sarunashi juice (sar-j) in Japan, on mutagenesis, inflammation, and mouse skin tumorigenesis. The components of A. arguta responsi...
Citation: Genes and Environment 2022 44:26 -
Easily-controllable, helper phage-free single-stranded phagemid production system
Single-stranded (ss) DNAs are utilized in various molecular biological and biotechnological applications including the construction of double-stranded DNAs with a DNA lesion, and are commonly prepared by using...
Citation: Genes and Environment 2022 44:25 -
In vivo genotoxicity assessment of a multiwalled carbon nanotube in a mouse ex vivo culture
Multiwalled carbon nanotubes (MWCNTs) are suspected lung carcinogens because their shape and size are similar to asbestos. Various MWCNT types are manufactured; however, only MWNT-7 is classified into Group 2B...
Citation: Genes and Environment 2022 44:24
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