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  1. Content type: Research

    Kaolin is white clay mineral with the chemical composition Al2Si2O5(OH)4, and many varieties of kaolins having different crystal structures are utilized in industrial, cosmetic and medical fields. To evaluate the...

    Authors: Tatsuya Kato, Tatsushi Toyooka, Yuko Ibuki, Shuichi Masuda, Masatoshi Watanabe and Yukari Totsuka

    Citation: Genes and Environment 2017 39:12

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  5. Content type: Letter to the Editor

    The Japanese Environmental Mutagen Society (JEMS) was established in 1972 by 147 members, 11 of whom are still on the active list as of May 1, 2016. As one of them, I introduce some historic topics here. These...

    Authors: Shizuyo Sutou

    Citation: Genes and Environment 2017 39:9

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  7. Content type: Letter to the Editor

    The evolution of methods to assess genotoxicity of test compounds is thought to be one of the important subjects in The Japanese Environmental and Mutagen Society (JEMS). In 1970, the Ministry of Education of...

    Authors: Toshio Sofuni

    Citation: Genes and Environment 2017 39:15

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  8. Content type: Review

    Rats are a standard experimental animal for cancer bioassay and toxicological research for chemicals. Although the genetic analyses were behind mice, rats have been more frequently used for toxicological resea...

    Authors: Takehiko Nohmi, Kenichi Masumura and Naomi Toyoda-Hokaiwado

    Citation: Genes and Environment 2017 39:11

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  10. Content type: Research

    Cytochrome P450 CYP1A1 helps detoxify the potential carcinogens in tobacco smoke, it was reported that polymorphisms in the coding gene result in variation in the expression and activity levels which alter met...

    Authors: Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El-Bastawisy, Mirhane Hassan, Shereen Abd El-Aziz, Mohamed Abdel-Hamid and Amal Saad-Hussein

    Citation: Genes and Environment 2017 39:7

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  11. Content type: Research

    Interactions between genes and environment are critical factors for causing cancer in humans. The genotoxicity of environmental chemicals can be enhanced via the modulation of susceptible genes in host human c...

    Authors: Yuki Kanemaru, Tetsuya Suzuki, Akira Sassa, Kyomu Matsumoto, Noritaka Adachi, Masamitsu Honma, Satoshi Numazawa and Takehiko Nohmi

    Citation: Genes and Environment 2017 39:6

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  12. Content type: Research

    A powdered ethanolic extract of Glycyrrhiza aspera root exhibits antimutagenic activity against N-methyl-N-nitrosourea (MNU) based on the Ames assay with Salmonella typhimurium TA1535. The aim of this study was t...

    Authors: Keiko Inami, Yusuke Mine, Jin Tatsuzaki, Chihiro Mori and Masataka Mochizuki

    Citation: Genes and Environment 2017 39:5

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  13. Content type: Short report

    It is known that fibrous particles of micrometer length, such as carbon nanotubes, which have same dimensions as asbestos, are carcinogenic. Carcinogenicity of nanomaterials is strongly related to inflammatory...

    Authors: Katsuyoshi Horibata, Akiko Ukai, Akio Ogata, Dai Nakae, Hiroshi Ando, Yoshikazu Kubo, Akemichi Nagasawa, Katsuhiro Yuzawa and Masamitsu Honma

    Citation: Genes and Environment 2017 39:4

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  14. Content type: Review

    Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated f...

    Authors: Shosuke Kawanishi, Shiho Ohnishi, Ning Ma, Yusuke Hiraku, Shinji Oikawa and Mariko Murata

    Citation: Genes and Environment 2017 38:26

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  17. Content type: Review

    Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major products is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). The mutagenic potentials of this oxidized base have been exa...

    Authors: Tetsuya Suzuki and Hiroyuki Kamiya

    Citation: Genes and Environment 2016 39:2

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    The Erratum to this article has been published in Genes and Environment 2017 39:20

  18. Content type: Research

    Actinidia arguta, known as sarunashi in Japan, is a vine tree native to east-Asia, including Japan, that produces small fruit rich in anthocyanins, catechins, vitamin C, chlorophyll, b...

    Authors: Mari Nishimura, Yuma Okimasu, Naoko Miyake, Misako Tada, Ryoko Hida, Tomoe Negishi and Sakae Arimoto-Kobayashi

    Citation: Genes and Environment 2016 38:25

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  19. Content type: Research

    We investigated the enhancing effect of metal ions on several mutagens and examined their mechanism of action. We performed the Ames tests on six mutagens, i.e., 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, 4-ni...

    Authors: Nobuyoshi Fujii, Shigemitsu Yano and Kenji Takeshita

    Citation: Genes and Environment 2016 38:21

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  21. Content type: Research

    Carcinogens are known to cause swelling of the mammalian cell nucleus. However, the mechanism of the swelling and its toxicological significance have not been fully elucidated. Since nuclear swelling (NS herea...

    Authors: Kenji Takeshita, Hiroaki I. Ogawa and Toshinari Maeda

    Citation: Genes and Environment 2016 38:22

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  23. Content type: Short report

    Cytosine residues in CpG dinucleotides often undergo various types of modification, such as methylation, deamination, and halogenation. These types of modifications can be pro-mutagenic and can contribute to t...

    Authors: Akira Sassa, Yuki Kanemaru, Nagisa Kamoshita, Masamitsu Honma and Manabu Yasui

    Citation: Genes and Environment 2016 38:17

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  25. Content type: Review

    Toxicogenomics is a rapidly developing discipline focused on the elucidation of the molecular and cellular effects of chemicals on biological systems. As a collaborative study group of Toxicogenomics/JEMS·MMS,...

    Authors: Chie Furihata, Takashi Watanabe, Takayoshi Suzuki, Shuichi Hamada and Madoka Nakajima

    Citation: Genes and Environment 2016 38:15

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  26. Content type: Review

    Cancer is now the leading cause of death in Japan. A rapid increase in cancer mortality is expected as Japan is facing a super-aged society. Many causes of cancer are known to be closely linked to life style f...

    Authors: Yasusei Kudo, Hidesuke Tada, Natsumi Fujiwara, Yoshiko Tada, Takaaki Tsunematsu, Yoichiro Miyake and Naozumi Ishimaru

    Citation: Genes and Environment 2016 38:13

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  29. Content type: Reviewer acknowledgement

    The editors of Genes and Environment would like to thank all our reviewers who have contributed to the journal in Volume XXXVII (2015).

    Authors: Takashi Yagi

    Citation: Genes and Environment 2016 39:1

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    The Erratum to this article has been published in Genes and Environment 2017 39:20

  30. Content type: Commentary

    The linear no-threshold model (LNT) has been the basis for radiation protection policies worldwide for 60 years. LNT was fabricated without correct data. The lifespan study of Atomic bomb survivors (LSS) has p...

    Authors: Shizuyo Sutou

    Citation: Genes and Environment 2016 38:12

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  31. Content type: Review

    The mucosal immune system is unique to the gastrointestinal mucosa, in which a large number of immune cells are located and exert multiple functions. Meanwhile, ~100 trillion microorganisms are thought to co-i...

    Authors: Mayuko Yamamoto and Satoshi Matsumoto

    Citation: Genes and Environment 2016 38:11

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  34. Content type: Research

    Germline mutations are heritable and may cause health disadvantages in the next generation. To investigate trans-generational mutations, we treated male gpt delta mice with N-ethyl-N-nitrosourea (ENU) (85 mg/kg i...

    Authors: Kenichi Masumura, Naomi Toyoda-Hokaiwado, Akiko Ukai, Yoichi Gondo, Masamitsu Honma and Takehiko Nohmi

    Citation: Genes and Environment 2016 38:10

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  35. Content type: Review

    Evidence from epidemiological and experimental studies has shown that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colorectal cancer (CRC). The function of NSAIDs and the molecular targets...

    Authors: Takahiro Hamoya, Gen Fujii, Shingo Miyamoto, Mami Takahashi, Yukari Totsuka, Keiji Wakabayashi, Jiro Toshima and Michihiro Mutoh

    Citation: Genes and Environment 2016 38:6

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  36. Content type: Research

    Pesticide exposure possesses risk of genotoxicity to humans, particularly farmers. Despite accumulating evidences linking genotoxicity to pesticide exposure, epidemiological studies to address pesticide toxici...

    Authors: Zariyantey Abdul Hamid, Mohd Faizal Mohd Zulkifly, Asmah Hamid, Syarif Husin Lubis, Nihayah Mohammad, Ismarulyusda Ishak, Nur Zakiah Mohd Saat, Hidayatul Fathi Othman, Ahmad Rohi Ghazali, Mohd Jamil Mohd Rafaai, Mohamad Roff Mohd Noor and Nor Fadilah Rajab

    Citation: Genes and Environment 2016 38:7

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  37. Content type: Short report

    The study was carried out to identify the polymorphisms in mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo population and to correlate the involvement of demographic factors.

    Authors: Freda Lalrohlui, Sunaina Thapa, Souvik Ghatak, John Zohmingthanga and Nachimuthu Senthil Kumar

    Citation: Genes and Environment 2016 38:5

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  39. Content type: Short report

    Several alkenylbenzenes, including methyleugenol (ME), are present in a wide range of botanicals and exhibit carcinogenic and mutagenic properties. Negative results are generally obtained for alkenylbenzenes i...

    Authors: Hiroshi Honda, Kazuyuki Minegawa, Yurika Fujita, Noriko Yamaguchi, Yoshihiro Oguma, Hansruedi Glatt, Naohiro Nishiyama and Toshio Kasamatsu

    Citation: Genes and Environment 2016 38:1

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  40. Content type: Review

    Tobacco smoking is a major cause of lung cancer. It has been suggested that there is an approximately linear dose–response relationship between the number of cigarettes smoked per day and clinical outcome such...

    Authors: Masahiko Watanabe

    Citation: Genes and Environment 2016 38:3

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  41. Content type: Commentary

    The bacterial reverse mutation test, commonly called Ames test, is used worldwide. In Japan, the genetically modified organisms (GMOs) are regulated under the Cartagena Domestic Law, and organisms obtained by ...

    Authors: Kei-ichi Sugiyama, Masami Yamada, Takumi Awogi and Atsushi Hakura

    Citation: Genes and Environment 2016 38:2

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  42. Content type: Research

    Asian dust events, transport of dust particles from arid and semi-arid areas in China and Mongolia to the east by prevailing westerlies, are often observed in Japan in spring. In recent decades, consumption of...

    Authors: Souleymane Coulibaly, Hiroki Minami, Maho Abe, Tomohiro Hasei, Tadashi Oro, Kunihiro Funasaka, Daichi Asakawa, Masanari Watanabe, Naoko Honda, Keiji Wakabayashi and Tetsushi Watanabe

    Citation: Genes and Environment 2015 37:25

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  43. Content type: Research

    Transgenic gpt delta mouse and rat models were developed to perform gpt and Spi− assays for in vivo mutagenicity tests. The animals were established by integration of lambda EG10 phage DNA as a transgene into the...

    Authors: Kenichi Masumura, Yasuteru Sakamoto, Wakako Kumita, Masamitsu Honma, Akiyoshi Nishikawa and Takehiko Nohmi

    Citation: Genes and Environment 2015 37:24

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  45. Content type: Short report

    2,2,4-Triamino-5(2H)-oxazolone (Oz) in a DNA strand is an oxidation product of guanine and 8-oxo-7, 8-dihydroguanine, and such a lesion can cause G-to-C transversions. Previously, Fpg/Nei and Nth were shown to ha...

    Authors: Katsuhito Kino, Masayo Suzuki, Masayuki Morikawa, Takanobu Kobayashi, Shigenori Iwai and Hiroshi Miyazawa

    Citation: Genes and Environment 2015 37:22

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  48. Content type: Research article

    The nicotinic α5 receptor subunit, encoded by CHRNA5, harbors multiple functional single nucleotide polymorphisms (SNPs) that affect mRNA expression and alter the encoded protein. These polymorphisms are most not...

    Authors: Jessica E. Ramsay, C. Harker Rhodes, Keerthi Thirtamara-Rajamani and Ryan M. Smith

    Citation: Genes and Environment 2015 37:14

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  49. Content type: Research article

    Progerin, the protein responsible for the Hutchinson-Gilford Progeria Syndrome (HGPS), is a partially deleted form of nuclear lamin A, and its expression has been suggested as a cause for dysfunctional nuclear...

    Authors: Asao Noda, Shuji Mishima, Yuko Hirai, Kanya Hamasaki, Reid D. Landes, Hiroshi Mitani, Kei Haga, Tohru Kiyono, Nori Nakamura and Yoshiaki Kodama

    Citation: Genes and Environment 2015 37:13

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  50. Content type: Research article

    According to published information, it has not been determined whether the inhalation of cigarette smoke can induce chromosome aberrations and/or point mutations in mice, though cigarette smoke is clearly carc...

    Authors: Takanori Nakamura, Yumi Ishida, Kasumi Ainai, Shigeto Nakamura, Satoru Shirata, Kazuhiro Murayama, Shin-ichiro Kurimoto, Katsuyasu Saigo, Ryo Murashige, Shuji Tsuda and Yu F. Sasaki

    Citation: Genes and Environment 2015 37:17

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0.516 - SCImago Journal Rank (SJR)
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Genes and Environment

ISSN: 1880-7062

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