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  1. Research

    Structural chromosome aberrations cause swelling of the nucleus

    Carcinogens are known to cause swelling of the mammalian cell nucleus. However, the mechanism of the swelling and its toxicological significance have not been fully elucidated. Since nuclear swelling (NS herea...

    Kenji Takeshita, Hiroaki I. Ogawa and Toshinari Maeda

    Genes and Environment 2016 38:22

    Published on: 1 October 2016

  2. Review

    Oral environment and cancer

    Cancer is now the leading cause of death in Japan. A rapid increase in cancer mortality is expected as Japan is facing a super-aged society. Many causes of cancer are known to be closely linked to life style f...

    Yasusei Kudo, Hidesuke Tada, Natsumi Fujiwara, Yoshiko Tada, Takaaki Tsunematsu, Yoichiro Miyake and Naozumi Ishimaru

    Genes and Environment 2016 38:13

    Published on: 1 August 2016

  3. Review

    Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics

    Toxicogenomics is a rapidly developing discipline focused on the elucidation of the molecular and cellular effects of chemicals on biological systems. As a collaborative study group of Toxicogenomics/JEMS·MMS,...

    Chie Furihata, Takashi Watanabe, Takayoshi Suzuki, Shuichi Hamada and Madoka Nakajima

    Genes and Environment 2016 38:15

    Published on: 1 August 2016

  4. Reviewer acknowledgement

    Acknowledgement to reviewers

    The editors of Genes and Environment would like to thank all our reviewers who have contributed to the journal in Volume XXXVII (2015).

    Takashi Yagi

    Genes and Environment 2016 39:1

    Published on: 22 June 2016

    The Erratum to this article has been published in Genes and Environment 2017 39:20

  5. Commentary

    A message to Fukushima: nothing to fear but fear itself

    The linear no-threshold model (LNT) has been the basis for radiation protection policies worldwide for 60 years. LNT was fabricated without correct data. The lifespan study of Atomic bomb survivors (LSS) has p...

    Shizuyo Sutou

    Genes and Environment 2016 38:12

    Published on: 1 June 2016

  6. Review

    Gut microbiota and colorectal cancer

    The mucosal immune system is unique to the gastrointestinal mucosa, in which a large number of immune cells are located and exert multiple functions. Meanwhile, ~100 trillion microorganisms are thought to co-i...

    Mayuko Yamamoto and Satoshi Matsumoto

    Genes and Environment 2016 38:11

    Published on: 1 June 2016

  7. Review

    Mechanisms of interstrand DNA crosslink repair and human disorders

    Interstrand DNA crosslinks (ICLs) are the link between Watson-Crick strands of DNAs with the covalent bond and prevent separation of DNA strands. Since the ICL lesion affects both strands of the DNA, the ICL r...

    Satoru Hashimoto, Hirofumi Anai and Katsuhiro Hanada

    Genes and Environment 2016 38:9

    Published on: 1 May 2016

  8. Research

    Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice

    Germline mutations are heritable and may cause health disadvantages in the next generation. To investigate trans-generational mutations, we treated male gpt delta mice with N-ethyl-N-nitrosourea (ENU) (85 mg/kg i...

    Kenichi Masumura, Naomi Toyoda-Hokaiwado, Akiko Ukai, Yoichi Gondo, Masamitsu Honma and Takehiko Nohmi

    Genes and Environment 2016 38:10

    Published on: 1 April 2016

  9. Review

    Effects of NSAIDs on the risk factors of colorectal cancer: a mini review

    Evidence from epidemiological and experimental studies has shown that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colorectal cancer (CRC). The function of NSAIDs and the molecular targets...

    Takahiro Hamoya, Gen Fujii, Shingo Miyamoto, Mami Takahashi, Yukari Totsuka, Keiji Wakabayashi, Jiro Toshima and Michihiro Mutoh

    Genes and Environment 2016 38:6

    Published on: 1 April 2016

  10. Research

    The association of nuclear abnormalities in exfoliated buccal epithelial cells with the health status of different agricultural activities farmers in Peninsular Malaysia

    Pesticide exposure possesses risk of genotoxicity to humans, particularly farmers. Despite accumulating evidences linking genotoxicity to pesticide exposure, epidemiological studies to address pesticide toxici...

    Zariyantey Abdul Hamid, Mohd Faizal Mohd Zulkifly, Asmah Hamid, Syarif Husin Lubis, Nihayah Mohammad, Ismarulyusda Ishak, Nur Zakiah Mohd Saat, Hidayatul Fathi Othman, Ahmad Rohi Ghazali, Mohd Jamil Mohd Rafaai, Mohamad Roff Mohd Noor and Nor Fadilah Rajab

    Genes and Environment 2016 38:7

    Published on: 1 March 2016

  11. Short report

    Mitochondrial complex I and V gene polymorphisms in type II diabetes mellitus among high risk Mizo-Mongoloid population, Northeast India

    The study was carried out to identify the polymorphisms in mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo population and to correlate the involvement of demographic factors.

    Freda Lalrohlui, Sunaina Thapa, Souvik Ghatak, John Zohmingthanga and Nachimuthu Senthil Kumar

    Genes and Environment 2016 38:5

    Published on: 1 March 2016

  12. Short report

    Modified Ames test using a strain expressing human sulfotransferase 1C2 to assess the mutagenicity of methyleugenol

    Several alkenylbenzenes, including methyleugenol (ME), are present in a wide range of botanicals and exhibit carcinogenic and mutagenic properties. Negative results are generally obtained for alkenylbenzenes i...

    Hiroshi Honda, Kazuyuki Minegawa, Yurika Fujita, Noriko Yamaguchi, Yoshihiro Oguma, Hansruedi Glatt, Naohiro Nishiyama and Toshio Kasamatsu

    Genes and Environment 2016 38:1

    Published on: 7 February 2016

  13. Commentary

    The strains recommended for use in the bacterial reverse mutation test (OECD guideline 471) can be certified as non-genetically modified organisms

    The bacterial reverse mutation test, commonly called Ames test, is used worldwide. In Japan, the genetically modified organisms (GMOs) are regulated under the Cartagena Domestic Law, and organisms obtained by ...

    Kei-ichi Sugiyama, Masami Yamada, Takumi Awogi and Atsushi Hakura

    Genes and Environment 2016 38:2

    Published on: 22 January 2016

  14. Review

    Smoking: additional burden on aging and death

    Tobacco smoking is a major cause of lung cancer. It has been suggested that there is an approximately linear dose–response relationship between the number of cigarettes smoked per day and clinical outcome such...

    Masahiko Watanabe

    Genes and Environment 2016 38:3

    Published on: 22 January 2016

  15. Research

    Long-range transport of mutagens and other air pollutants from mainland East Asia to western Japan

    Asian dust events, transport of dust particles from arid and semi-arid areas in China and Mongolia to the east by prevailing westerlies, are often observed in Japan in spring. In recent decades, consumption of...

    Souleymane Coulibaly, Hiroki Minami, Maho Abe, Tomohiro Hasei, Tadashi Oro, Kunihiro Funasaka, Daichi Asakawa, Masanari Watanabe, Naoko Honda, Keiji Wakabayashi and Tetsushi Watanabe

    Genes and Environment 2015 37:25

    Published on: 8 December 2015

  16. Research

    Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents

    Transgenic gpt delta mouse and rat models were developed to perform gpt and Spi assays for in vivo mutagenicity tests. The animals were established by integration of lambda EG10 phage DNA as a transgene into the...

    Kenichi Masumura, Yasuteru Sakamoto, Wakako Kumita, Masamitsu Honma, Akiyoshi Nishikawa and Takehiko Nohmi

    Genes and Environment 2015 37:24

    Published on: 1 December 2015

  17. Short report

    Chlorella virus pyrimidine dimer glycosylase and Escherichia coli endonucleases IV and V have incision activity on 2,2,4-triamino-5(2H)-oxazolone

    2,2,4-Triamino-5(2H)-oxazolone (Oz) in a DNA strand is an oxidation product of guanine and 8-oxo-7, 8-dihydroguanine, and such a lesion can cause G-to-C transversions. Previously, Fpg/Nei and Nth were shown to ha...

    Katsuhito Kino, Masayo Suzuki, Masayuki Morikawa, Takanobu Kobayashi, Shigenori Iwai and Hiroshi Miyazawa

    Genes and Environment 2015 37:22

    Published on: 1 November 2015

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