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  1. Non-Small Cell Lung Cancer displays several genetic mutations including epidermal growth factor receptor. This study's objective was to determine if the EGFR exon19 rs121913438 and exon21 rs121434568 variation...

    Authors: Omali Y. El-khawaga, Mohammed F. Al-azzawy, Afaf M. ElSaid, Sherif Refaat and Aliaa N. El-Dawa
    Citation: Genes and Environment 2023 45:32
  2. Aflatoxin B1 (AFB1) is a mycotoxin produced by several species of Aspergillus fungi which can cause liver cancer in animals and humans. This study aims to perform the risk assessment of AFB1 in herbal medicines a...

    Authors: Siti Soleha Ab Dullah, Mohd Redzwan Sabran, Ab Hamid Hasiah and Rozaini Abdullah
    Citation: Genes and Environment 2023 45:31
  3. Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic en...

    Authors: Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma and Kei-ichi Sugiyama
    Citation: Genes and Environment 2023 45:30
  4. tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester. It is a high-production chemical...

    Authors: Yasumasa Murata, Kenichiro Suzuki, Yoshiyuki Shigeta, Takako Iso, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura and Mariko Matsumoto
    Citation: Genes and Environment 2023 45:29
  5. The species of genus Macaranga are widely found in Malaysian secondary forests and has been used as an alternative for treating varieties of illness. Studies have shown that the medicinal properties of this genus...

    Authors: Ee Ling Siew, Lishantini Pearanpan, Zhafri Zamkhuri, Fariza Juliana Nordin, Theng Choon Ooi, Kok Meng Chan, Aisyah Salihah Kamarozaman, Norizan Ahmat and Nor Fadilah Rajab
    Citation: Genes and Environment 2023 45:28
  6. The DNA-damaging compounds in heated cooking oil were identified as guanosine adducts. Heated vegetable oil was subjected to deep-frying conditions at 170 °C for 45 min, reacted with isopropylidene guanosine (...

    Authors: Hiroshi Kasai and Kazuaki Kawai
    Citation: Genes and Environment 2023 45:27
  7. The aim of this study was to assess the correlation of spouse selection with short tandem repeats (STRs) in DNA and with the number of fingertip lunulae to investigate the role of heredity in spouse selection.

    Authors: Qi Xia, Ullah Anwar, Yu Weijian, Wang Yingshuai and Liu Hui
    Citation: Genes and Environment 2023 45:26
  8. Prostate cancer is one of the most common cancers among men worldwide and the fourth most common cause of death. The number of prostate cancer cases and deaths is increasing every year because of population ag...

    Authors: Ayako Maeda-Minami, Tomoki Nishikawa, Hideki Ishikawa, Michihiro Mutoh, Kazunori Akimoto, Yutaka Matsuyama, Yasunari Mano and Hiroji Uemura
    Citation: Genes and Environment 2023 45:25
  9. Chronic obstructive pulmonary disease (COPD) is a serious health burden worldwide with high mortality. LncRNA plasmacytoma variant translocation 1 (PVT1) has been illustrated to serve as a biomarker for COPD p...

    Authors: Taoli Fu, Hui Tian, Hui Rong, Ping Ai and Xiaoping Li
    Citation: Genes and Environment 2023 45:24
  10. Evidence showed that N6-methyladenosine (m6A) is strongly associated with male germline development. However, the role of m6A methylation on circRNAs in amphibians remains unknown. In this study, we conducted m6A...

    Authors: Xin Zhang, Linlin Sai, Weiliang Zhang, Xingzheng Kan, Qiang Jia, Cunxiang Bo, Wenhui Yin, Hua Shao, Mingming Han and Cheng Peng
    Citation: Genes and Environment 2023 45:23
  11. Understanding of metabolic processes is a key factor to evaluate biological effects of carcinogen and mutagens. Applicability of fused-grid Template* systems of CYP enzymes (Drug Metab Pharmacokinet 2019, 2020...

    Authors: Yasushi Yamazoe, Norie Murayama, Tomoko Kawamura and Takashi Yamada
    Citation: Genes and Environment 2023 45:22
  12. Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced D...

    Authors: Huizeng Wang, Bingchun Liu, Hong Chen, Peixin Xu, Huiting Xue and Jianlong Yuan
    Citation: Genes and Environment 2023 45:21
  13. Colorectal cancer (CRC) has been ranked as the second most deadly cancer and the third most diagnosed cancer cases for the year 2020. Specifically for Romania, the number of CRC-related deaths in 2019 was esti...

    Authors: Felix Manirakiza, Hidetaka Yamada, Yuji Iwashita, Keiko Ishino, Rei Ishikawa, Zsolt Kovacs, Eva Osvath, Augustin Nzitakera, Simona Gurzu and Haruhiko Sugimura
    Citation: Genes and Environment 2023 45:20
  14. We investigated the chemopreventive effects of beer, nonalcoholic beers (NABs), and beer-components (glycine betaine (GB)) on NNK-induced lung tumorigenesis in A/J mice, and the possible mechanisms underlying ...

    Authors: Jun Takata, Katsuyuki Kiura, Takamasa Nakasuka, Atsuko Hirabae and Sakae Arimoto-Kobayashi
    Citation: Genes and Environment 2023 45:19
  15. Helicobacter pylori secretes cytotoxin-associated gene A (CagA) into the gastric epithelium, causing gastric mucosal atrophy (GMA) and gastric cancer. In contrast, host cells degrade CagA via autophagy. However, ...

    Authors: Naoyuki Yamaguchi, Takuki Sakaguchi, Hajime Isomoto, Tatsuo Inamine, Ryoya Tsukamoto, Daisuke Fukuda, Ken Ohnita, Tsutomu Kanda, Kayoko Matsushima, Tatsuro Hirayama, Kazuo Yashima and Kazuhiro Tsukamoto
    Citation: Genes and Environment 2023 45:18
  16. Environmental heat stress in dairy cattle leads to poor health, reduced milk production and decreased reproductive efficiency. Multiple genes interact and coordinate the response to overcome the impact of heat...

    Authors: Basavaraj Sajjanar, Mohd Tanzeel Aalam, Owais Khan, Gunturu Narasimha Tanuj, Aditya Prasad Sahoo, Gundallahalli B. Manjunathareddy, Ravi Kumar Gandham, Sujoy K. Dhara, Praveen K. Gupta, Bishnu Prasad Mishra, Triveni Dutt and Gyanendra Singh
    Citation: Genes and Environment 2023 45:17
  17. The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects of low dose and low dose rate ionizing radiation below 10...

    Authors: Vinay Jain, Divyalakshmi Saini, D. C. Soren, V. Anil Kumar, P. R. Vivek Kumar, P. K. M. Koya, G. Jaikrishan and Birajalaxmi Das
    Citation: Genes and Environment 2023 45:16
  18. Chronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in translesion DNA synthesis, counteracts mutagenesis induced ...

    Authors: Atsushi Hakura, Hajime Sui, Yuki Seki, Jiro Sonoda, Yusaku Yoshida, Hisayoshi Takagi, Shigeo Yokose, Tomonari Matsuda, Shoji Asakura and Takehiko Nohmi
    Citation: Genes and Environment 2023 45:15
  19. The use of organotypic human tissue models in genotoxicity has increased as an alternative to animal testing. Genotoxicity is generally examined using a battery of in vitro assays such as Ames and micronucleus...

    Authors: Satoru Munakata, Taku Watanabe, Tomohiro Takahashi, Shiori Kimuro, Kanae Ishimori and Tsuneo Hashizume
    Citation: Genes and Environment 2023 45:14
  20. DNA oxidatively damaged by reactive oxygen species is repaired by base excision repair (BER) pathway proteins, with DNA glycosylases removing damaged or mismatched bases in the first step of BER. KsgA is a mul...

    Authors: Yuichiro Hayashi, Masafumi Funakoshi, Kaname Hirosawa and Qiu-Mei Zhang-Akiyama
    Citation: Genes and Environment 2023 45:13
  21. Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a smal...

    Authors: Yasumasa Murata, Masakatsu Natsume, Takako Iso, Yoshiyuki Shigeta, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura, Akihiko Hirose and Mariko Matsumoto
    Citation: Genes and Environment 2023 45:12
  22. Apoptotic cell death is an important survival system for multicellular organisms because it removes damaged cells. Mutation is also a survival method for dealing with damaged cells in multicellular and also un...

    Authors: Megumi Toyoshima-Sasatani, Fumika Imura, Yuko Hamatake, Akihiro Fukunaga and Tomoe Negishi
    Citation: Genes and Environment 2023 45:11
  23. Exposure to certain chemicals in the environment may contribute to the risk of developing cancer. Although cancer risk from environmental chemical exposure among general populations is considered low compared ...

    Authors: Motoki Iwasaki, Hiroaki Itoh, Norie Sawada and Shoichiro Tsugane
    Citation: Genes and Environment 2023 45:10
  24. The Open Symposium of the Japanese Environmental Mutagen and Genome Society (JEMS) entitled “Analytical technologies to revolutionize the environmental mutagenesis and genome research -From the basics to the c...

    Authors: Naoki Koyama and Akira Sassa
    Citation: Genes and Environment 2023 45:9
  25. Colibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal cancer (CRC) of their symbiosis hosts, including human. A peptidase ClbP is ...

    Authors: Tao Zhou, Takayuki Ando, Akihiro Kudo, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi and Kenji Watanabe
    Citation: Genes and Environment 2023 45:8
  26. Next-generation RNA sequencing (RNA-Seq) has identified more differentially expressed protein-coding genes (DEGs) and provided a wider quantitative range of expression level changes than conventional DNA micro...

    Authors: Chie Furihata and Takayoshi Suzuki
    Citation: Genes and Environment 2023 45:7
  27. Heat shock proteins (Hsps) are overexpressed in several tumors and contribute to cell proliferation, metastasis, and anticancer drug resistance. Therefore, Hsp inhibitors have enhanced cytotoxicity as chemothe...

    Authors: Takahiro Matsumoto, Erika Ohnishi, Takahiro Kitagawa, Masaya Okayama, Youhei Saito, Hayato Yoshikawa, Tomoe Ohta, Tatsusada Yoshida, Yuji Nakayama and Tetsushi Watanabe
    Citation: Genes and Environment 2023 45:5
  28. Genotoxicity in tissues other than hematopoietic tissues, such as the liver and gastrointestinal (GI) tract, is an important focus in the risk assessment of chemicals in humans. We previously developed a rat m...

    Authors: Wakako Ohyama, Yohei Fujiishi, Emiko Okada, Kazunori Narumi and Makoto Hayashi
    Citation: Genes and Environment 2023 45:4
  29. Non-thermal atmospheric pressure plasma technologies form the core of many scientific advances, including in the electronic, industrial, and biotechnological fields. The use of plasma as a cancer therapy has r...

    Authors: Yang Liu, Yoshimichi Nakatsu, Hiromasa Tanaka, Kazunori Koga, Kenji Ishikawa, Masaharu Shiratani and Masaru Hori
    Citation: Genes and Environment 2023 45:3
  30. Cancer is the primary cause of human mortality in Japan since 1981. Although numerous novel therapies have been developed and applied in clinics, the number of deaths from cancer is still increasing worldwide....

    Authors: Shinya Toyokuni, Yingyi Kong, Yashiro Motooka and Shinya Akatsuka
    Citation: Genes and Environment 2023 45:2
  31. Mutation spectrum of TP53 in gastric cancer (GC) has been investigated world-widely, but a comparison of mutation spectrum among GCs from various regions in the world are still sparsely documented. In order to id...

    Authors: Hiroko Natsume, Kinga Szczepaniak, Hidetaka Yamada, Yuji Iwashita, Marta Gędek, Jelena Šuto, Keiko Ishino, Rika Kasajima, Tomonari Matsuda, Felix Manirakiza, Augustin Nzitakera, Yijia Wu, Nong Xiao, Qiong He, Wenwen Guo, Zhenming Cai…
    Citation: Genes and Environment 2023 45:1
  32. Previously, we reported the inhibitory effect of Actinidia arguta juice, known as sarunashi juice (sar-j) in Japan, on mutagenesis, inflammation, and mouse skin tumorigenesis. The components of A. arguta responsi...

    Authors: Jun Takata, Naoko Miyake, Yusuke Saiki, Misako Tada, Kensuke Sasaki, Toshio Kubo, Katsuyuki Kiura and Sakae Arimoto-Kobayashi
    Citation: Genes and Environment 2022 44:26
  33. Multiwalled carbon nanotubes (MWCNTs) are suspected lung carcinogens because their shape and size are similar to asbestos. Various MWCNT types are manufactured; however, only MWNT-7 is classified into Group 2B...

    Authors: Katsuyoshi Horibata, Hironao Takasawa, Motoki Hojo, Yuhji Taquahashi, Miyuki Shigano, Satoshi Yokota, Norihiro Kobayashi, Kei-ichi Sugiyama, Masamitsu Honma and Shuichi Hamada
    Citation: Genes and Environment 2022 44:24
  34. Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary vascular remodeling, which can be caused by abnormal proliferation and migration of pulmonary artery smooth muscle cells (PASMCs). Sev...

    Authors: Ting Li, Xiaoqin Tan, Yuexia Huang, Jun Cui, Fan Chen and Ying Xiong
    Citation: Genes and Environment 2022 44:23
  35. The repeated-dose liver micronucleus (RDLMN) assay has been well-developed and applied because of its simplicity and the ease of integration into general toxicity studies which is the preferred method from the...

    Authors: Kensuke Satomoto, Isamu Suzuki, Koji Mita, Atsushi Wakita, Hiroshi Yamagata, Tatsuya Mitsumoto and Shuichi Hamada
    Citation: Genes and Environment 2022 44:21
  36. Bisphenol-A (BPA) is an important environmental contaminant with adverse health effects suspected to be mediated through epigenetic mechanisms. We had reported that the FLO1-dependent flocculation of transgeni...

    Authors: Kei-ichi Sugiyama, Mawo Kinoshita, Petr Grúz, Toshio Kasamatsu and Masamitsu Honma
    Citation: Genes and Environment 2022 44:20
  37. Patatin-like phospholipase domain containing 3 (PNPLA3) is the main nonalcoholic fatty liver disease (NAFLD) susceptibility. Its expression is regulated tightly by nutritional and energy status, but the mechan...

    Authors: Xiao Xu, Xiaojie Deng, Yunzhi Chen, Wen Xu, Fen Xu and Hua Liang
    Citation: Genes and Environment 2022 44:18
  38. The principal objective of this project was to investigate the Epidermal Growth Factor Receptor (EGFR) gene mutation characteristics of lung cancer patients, which can provide a molecular basis for explaining the...

    Authors: Jun-Ling Wang, Yu-Dong Fu, Yan-Hong Gao, Xiu-Ping Li, Qian Xiong, Rui Li, Bo Hou, Ruo-Shan Huang, Jun-Feng Wang, Jian-Kun Zhang, Jia-Ling Lv, Chao Zhang and Hong-Wei Li
    Citation: Genes and Environment 2022 44:17
  39. The most frequent malignancy in women is breast cancer (BC). Gastric cancer (GC) is also the leading cause of cancer-related mortality. Long non-coding RNAs (lncRNAs) are thought to be important neurotic regul...

    Authors: Mansoureh Azadeh, Ali Salehzadeh, Kamran Ghaedi and Soheila Talesh Sasani
    Citation: Genes and Environment 2022 44:16
  40. Purpurin (1,2,4-trihydroxy-9,10-anthraquinone), a natural red anthraquinone pigment, has historically been used as a textile dye. However, purpurin induced urinary bladder tumors in rats, and displayed a mutag...

    Authors: Hatasu Kobayashi, Yurie Mori, Ryo Iwasa, Yuichiro Hirao, Shinya Kato, Shosuke Kawanishi, Mariko Murata and Shinji Oikawa
    Citation: Genes and Environment 2022 44:15
  41. In eye-drop drug development, the additional genotoxicity tests in some cases might be necessary to assess genotoxicity in the ocular surface since the ocular surface is exposed directly to high drug concentra...

    Authors: Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono and Masaaki Kurata
    Citation: Genes and Environment 2022 44:14
  42. We previously developed a rodent gastrointestinal (GI) tract micronucleus (MN) test using the glandular stomach and/or colon, and evaluated this test method using several genotoxic carcinogens (clastogens) and...

    Authors: Emiko Okada, Yohei Fujiishi, Kazunori Narumi and Wakako Ohyama
    Citation: Genes and Environment 2022 44:12
  43. Several rodent models with chemically induced colon cancer have been developed. Among these models, dextran sulfate sodium (DSS), a colitis inducer, combined with azoxymethane as a colon mutagenic carcinogen, ...

    Authors: Atsushi Hakura, Naoki Koyama, Yuki Seki, Jiro Sonoda and Shoji Asakura
    Citation: Genes and Environment 2022 44:11
  44. Aromatic amines, often used as intermediates for pharmaceutical synthesis, may be mutagenic and therefore pose a challenge as metabolites or impurities in drug development. However, predicting the mutagenicity...

    Authors: Ayaka Furukawa, Satoshi Ono, Katsuya Yamada, Nao Torimoto, Mahoko Asayama and Shigeharu Muto
    Citation: Genes and Environment 2022 44:10
  45. Environmental pollution is a risk factor for adverse birth outcomes, especially preterm birth (PTB) and early-term birth (ETB). It has been revealed that exposure to fine particulate matter (PM2.5) during pregnan...

    Authors: Kaixin Cao, Hongyan Jin, Haoxin Li, Mengmeng Tang, Jianhong Ge, Zekang Li, Xiaoyun Wang and Xuetao Wei
    Citation: Genes and Environment 2022 44:9

Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).

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