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  1. The microbial ecosystem in the human gut varies between individuals with differences in diet. Selenium is one of most common trace elements in everyday diet, and selenium intake affects the human gut microbiot...

    Authors: Zi-xiong Zhang, Hua Xiang, Guo-gen Sun, Yan-hua Yang, Chen Chen and Tuo Li
    Citation: Genes and Environment 2021 43:56
    Content type: Research Published on:

  2. Neurodegenerative diseases are becoming major socio-economic burdens. However, most of them still have no effective treatment. Growing evidence indicates excess exposure to pesticides are involved in the devel...

    Authors: Guangxia Yu, Qianqian Su, Yao Chen, Lingyan Wu, Siying Wu and Huangyuan Li
    Citation: Genes and Environment 2021 43:55
    Content type: Review Published on:

  3. The PIG-A gene mutation assay is a valuable tool for measuring in vivo gene mutations in blood cells. The human PIG-A assay, used as a potential genotoxicity biomarker, is minimally invasive, sensitive, and cost-...

    Authors: Yiyi Cao, Jing Xi, Chuanxi Tang, Ziying Yang, Weiying Liu, Xinyue You, Nannan Feng, Xin Yu Zhang, Jingui Wu, Yingxin Yu and Yang Luan
    Citation: Genes and Environment 2021 43:54
    Content type: Research Published on:

  4. In 2020, we discovered glycoprotein 2 (GP2) variants associated with pancreatic cancer susceptibility in a genome-wide association study involving the Japanese population. Individuals carrying a missense coding v...

    Authors: Yingsong Lin, Masahiro Nakatochi, Naoki Sasahira, Makoto Ueno, Naoto Egawa, Yasushi Adachi and Shogo Kikuchi
    Citation: Genes and Environment 2021 43:53
    Content type: Review Published on:

  5. DNA adducts, covalent modifications to DNA due to exposure to specific carcinogens, cause the mispairing of DNA bases, which ultimately results in DNA mutations. DNA methylation in the promoter region, another...

    Authors: Yuto Matsushita, Yuji Iwashita, Shunsuke Ohtsuka, Ippei Ohnishi, Takashi Yamashita, Hideaki Miyake and Haruhiko Sugimura
    Citation: Genes and Environment 2021 43:52
    Content type: Research Published on:

  6. Thorium is ubiquitous in the environment and its relationship with birth defects is still under discussion. This study aimed to investigate the associations of maternal exposure to thorium with risk of neural ...

    Authors: Bin Wang, Yiming Pang, Yali Zhang, Le Zhang, Rongwei Ye, Lailai Yan, Zhiwen Li and Aiguo Ren
    Citation: Genes and Environment 2021 43:51
    Content type: Research Published on:

  7. Mutation, inflammation, and oxidative damage including lipid-peroxidation are factors involved in the development of cancer. We investigated the antimutagenic, in vivo and in vitro anti-inflammatory, and antioxid...

    Authors: Sakae Arimoto-Kobayashi, Ryoko Hida, Nana Fujii and Ryosuke Mochioka
    Citation: Genes and Environment 2021 43:50
    Content type: Research Published on:

  8. Increasing evidence suggested N6-methyladenosine (m6A) modification is crucial for male germline development. However, m6A modification of lncRNAs gains a little attention in amphibians in recent years. Xenopus l...

    Authors: Xuejie Qi, Xiao Geng, Juan Zhang, Binpeng Qu, Xin Zhang, Qiang Jia, Wenhui Yin, Cunxiang Bo, Yan Liu, Hao Li, Linlin Sai, Mingming Han and Cheng Peng
    Citation: Genes and Environment 2021 43:49
    Content type: Research Published on:

  12. Stress response is mediated by the transcription of stress-responsive genes. The F-box motif protein Saf1p is involved in SCF-E3 ligase mediated degradation of the adenine deaminase, Aah1p upon nutrient stress...

    Authors: Meenu Sharma, V. Verma and Narendra K. Bairwa
    Citation: Genes and Environment 2021 43:45
    Content type: Research Published on:

  13. To explore the role of folate metabolism in 1,3-Butadiene (BD)'s genotoxicity, we conducted a match-up study in BD-exposed workers in China to analyze the associations between the polymorphisms of methylenetet...

    Authors: Menglong Xiang, Zhi Wang, Peng Zou, Xi Ling, Guowei Zhang, Ziyuan Zhou, Jia Cao and Lin Ao
    Citation: Genes and Environment 2021 43:44
    Content type: Research Published on:

  14. Gene mutations induced in germ cells may be transmitted to the next generation and cause adverse effects such as genetic diseases. Certain mutations may result in infertility or death in early development. Thu...

    Authors: Kenichi Masumura, Tomoko Ando, Naomi Toyoda-Hokaiwado, Akiko Ukai, Takehiko Nohmi and Masamitsu Honma
    Citation: Genes and Environment 2021 43:43
    Content type: Research Published on:

  15. Rheumatoid arthritis (RA) is the most common autoimmune system diseases in our world. More studies in recent years have shown that FCRL gene polymorphisms is closely related to autoimmune diseases. It is suggeste...

    Authors: Yonghui Yang, Dandan Li, Chunjuan He, Linna Peng, Shishi Xing, Mei Bai, Hao Rong, Dongya Yuan, Yongjun He, Xue He, Li Wang and Tianbo Jin
    Citation: Genes and Environment 2021 43:42
    Content type: Research Published on:

  16. Ames test is used worldwide for detecting the bacterial mutagenicity of chemicals. In silico analyses of bacterial mutagenicity have recently gained acceptance by regulatory agencies; however, current in silico m...

    Authors: Atsushi Hakura, Takumi Awogi, Toshiyuki Shiragiku, Atsushi Ohigashi, Mika Yamamoto, Kayoko Kanasaki, Hiroaki Oka, Yasuaki Dewa, Shunsuke Ozawa, Kouji Sakamoto, Tatsuya Kato and Eiji Yamamura
    Citation: Genes and Environment 2021 43:41
    Content type: Research Published on:

  17. Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately...

    Authors: Xiaobo Dong, Jun Wang, Gesheng Wang, Jiayue Wang, Lei Wang and Yong Du
    Citation: Genes and Environment 2021 43:40
    Content type: Research Published on:

  18. Due to the complex structure and function of central nervous system (CNS), human CNS in vitro modeling is still a great challenge. Neurotoxicity testing of environmental chemicals mainly depends on the traditi...

    Authors: Yuanyuan Zheng, Fangrong Zhang, Shengmin Xu and Lijun Wu
    Citation: Genes and Environment 2021 43:39
    Content type: Review Published on:

  19. Chemical carcinogens to humans have been usually identified by epidemiological studies on the relationships between occupational or environmental exposure to the agents and specific cancer induction. In contra...

    Authors: Takehiko Nohmi and Masahiko Watanabe
    Citation: Genes and Environment 2021 43:38
    Content type: Review Published on:

  20. The liver micronucleus (MN) assay is an effective and important in vivo test for detecting genotoxic compounds. In particular, the repeated-dose liver MN (RDLMN) assay which greatly facilitates incorporation o...

    Authors: Miyuki Shigano, Hironao Takasawa and Shuichi Hamada
    Citation: Genes and Environment 2021 43:37
    Content type: Short report Published on:

  21. Pentavalent antimonial compounds are currently used to treat leishmaniasis and resistance to these drugs is a serious problem. Multidrug resistance protein is an efflux pump of the cell membrane that expels fo...

    Authors: Maryam Fekri Soofi Abadi, Alireza Moradabadi, Reza Vahidi, Saeedeh Shojaeepour, Sara Rostami, Iman Rad and Shahriar Dabiri
    Citation: Genes and Environment 2021 43:36
    Content type: Research Published on:

  22. Peroxiredoxin 1 (PRDX1) is a member of a ubiquitous family of thiol peroxidases that catalyze the reduction of peroxides, including hydrogen peroxide. It functions as an antioxidant enzyme, similar to catalase...

    Authors: Takahito Moriwaki, Akari Yoshimura, Yuki Tamari, Hiroyuki Sasanuma, Shunichi Takeda, Masayuki Seki and Keizo Tano
    Citation: Genes and Environment 2021 43:35
    Content type: Research Published on:

  23. Multi-walled carbon nanotube (MWCNT) is one of the most widely used manufactured nanomaterials, however, its potential harmful effect on human health is of great concern. Previously we have shown the acute and...

    Authors: Li Ju, Lijin Zhu, Hao Wu, Min Yu, Xianhong Yin, Zhenyu Jia, Lingfang Feng, Shibo Ying, Hailing Xia, Shuzhi Zhang, Jianlin Lou and Jun Yang
    Citation: Genes and Environment 2021 43:34
    Content type: Research Published on:

  27. Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA...

    Authors: Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama and Kenichi Masumura
    Citation: Genes and Environment 2021 43:30
    Content type: Research Published on:

  29. Alcohol consumption and the ingestion of red meat and oxidized cooking oil are risk factors of gastric and colorectal cancers. We reported that acetaldehyde (AcAld) is generated from Heme/Mb/Meat-Linoleate-EtO...

    Authors: Hiroshi Kasai and Kazuaki Kawai
    Citation: Genes and Environment 2021 43:28
    Content type: Research Published on:

  30. Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the ty...

    Authors: Yasunobu Aoki, Mizuki Ohno, Michiyo Matsumoto, Michi Matsumoto, Kenichi Masumura, Takehiko Nohmi and Teruhisa Tsuzuki
    Citation: Genes and Environment 2021 43:27
    Content type: Research Published on:

  31. To evaluate the relationship between transcription factor 7-like 2 (TCF7L2) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han p...

    Authors: Peng Xue, Haihong Cao, Zhimin Ma, Ying Zhou and Nian Wang
    Citation: Genes and Environment 2021 43:26
    Content type: Research Published on:

  32. Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have...

    Authors: Kenichi Masumura, Tomoko Ando, Akiko Ukai, Sho Fujiwara, Shigeo Yokose, Xinyue You, Takayoshi Suzuki, Hiroyuki Hayashi, Takehiko Nohmi, Hisayoshi Takagi and Masamitsu Honma
    Citation: Genes and Environment 2021 43:25
    Content type: Research Published on:

  34. Exposure to respirable crystalline silica (RCS) can induce accelerated silicosis (AS), a form of silicosis that is more progressive and severe form of silicosis. In this project we aimed to assess processes of...

    Authors: Linlin Sai, Xuejie Qi, Gongchang Yu, Juan Zhang, Yuxin Zheng, Qiang Jia and Cheng Peng
    Citation: Genes and Environment 2021 43:23
    Content type: Research Published on:

  35. Malaria is a disease annually causing over 400,000 deaths. Deep understanding of molecular and genetic processes underlying its life cycle and pathogenicity is required to efficiently resist it. RNA interferen...

    Authors: Alexandr Grinev, Natalya Fokina, Denis Bogomolov, Iza Berechikidze and Yuliya Lazareva
    Citation: Genes and Environment 2021 43:22
    Content type: Research Published on:

  38. We designed a case-control study to investigate the effect of vitamin D receptor gene (VDR) gene single nucleotide polymorphisms (SNPs) and possible gene- environment interaction on the susceptibility of renal...

    Authors: Tian Jianhai, Lv Jian, Zhang Long, Wang Wei, Zhang Shumao, Wang Yiming and Li Xiaojuan
    Citation: Genes and Environment 2021 43:19
    Content type: Research Published on:

  41. Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity...

    Authors: Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata and Masamitsu Honma
    Citation: Genes and Environment 2021 43:16
    Content type: Research Published on:

  42. CRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result ...

    Authors: Hussein Sabit, Shaimaa Abdel-Ghany, Huseyin Tombuloglu, Emre Cevik, Amany Alqosaibi, Fatma Almulhim and Afnan Al-Muhanaa
    Citation: Genes and Environment 2021 43:15
    Content type: Review Published on:

  43. Cancer is one of the main health challenges and leading causes of deaths in the world. Various environmental and genetic risk factors are associated with tumorigenesis. Epigenetic deregulations are also import...

    Authors: Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Abbaszadegan and Meysam Moghbeli
    Citation: Genes and Environment 2021 43:14
    Content type: Review Published on:

  44. Formaldehyde is a widely used but highly reactive and toxic chemical. The International Agency for Research on Cancer classifies formaldehyde as a Group 1 carcinogen, based on nasopharyngeal cancer and leukemi...

    Authors: Doo Seok Kang, Hyun Soo Kim, Jong-Hyeon Jung, Cheol Min Lee, Yeon-Soon Ahn and Young Rok Seo
    Citation: Genes and Environment 2021 43:13
    Content type: Review Published on:

  45. A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings. Recent technological developments have f...

    Authors: Ippei Ohnishi, Yuji Iwashita, Yuto Matsushita, Shunsuke Ohtsuka, Takashi Yamashita, Keisuke Inaba, Atsuko Fukazawa, Hideto Ochiai, Keigo Matsumoto, Nobuhito Kurono, Yoshitaka Matsushima, Hiroki Mori, Shioto Suzuki, Shohachi Suzuki, Fumihiko Tanioka and Haruhiko Sugimura
    Citation: Genes and Environment 2021 43:12
    Content type: Research Published on:

  46. The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue. The comet assay of hepatocytes is well established; however, t...

    Authors: Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono and Masaaki Kurata
    Citation: Genes and Environment 2021 43:11
    Content type: Research Published on:

  47. The PIGRET assay is one of the Pig-a assays targeting reticulocytes (RETs), an in vivo genotoxicity evaluation method using flow cytometry with endogenous reporter glycosylphosphatidylinositol anchor protein. The...

    Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata
    Citation: Genes and Environment 2021 43:10
    Content type: Method Published on:

  48. Radio-adaptive response (RAR) is transient phenomena, where cells conditioned with a small dose (priming) of ionizing radiation shows significantly reduced DNA damage with a subsequent high challenging dose. T...

    Authors: Shridevi Shelke and Birajalaxmi Das
    Citation: Genes and Environment 2021 43:9
    Content type: Research Published on:

  50. Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagen...

    Authors: Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura…
    Citation: Genes and Environment 2021 43:7
    Content type: Research Published on:

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