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  1. Review

    Generation, repair and replication of guanine oxidation products

    Guanine is the most readily oxidized of the four DNA bases, and guanine oxidation products cause G:C-T:A and G:C-C:G transversions through DNA replication. 8-Oxo-7,8-dihydroguanine (8-oxoG) causes G:C-T:A tran...

    Katsuhito Kino, Masayo Hirao-Suzuki, Masayuki Morikawa, Akane Sakaga and Hiroshi Miyazawa

    Genes and Environment 2017 39:21

    Published on: 1 August 2017

  2. Research

    Association between transported Asian dust and outdoor fungal concentration during winter in a rural area of western Japan

    Recently, Asian dust (AD) has become a serious health problem and several studies have clearly proven that AD can aggravate asthma. However, it remains unclear as to which components of AD have a strong effect...

    Kyoko Iwata, Masanari Watanabe, Jun Kurai, Naoto Burioka, Sachiko Nakamoto, Degejirihu Hantan and Eiji Shimizu

    Genes and Environment 2017 39:19

    Published on: 1 July 2017

  3. Research

    Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson’s disease: a case control study

    Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson’s disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associa...

    Anwarullah, Muhammad Aslam, Mazhar Badshah, Rashda Abbasi, Aneesa Sultan, Kafaitullah Khan, Nafees Ahmad and Jakob von Engelhardt

    Genes and Environment 2017 39:18

    Published on: 1 July 2017

  4. Research

    Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D3 analog, pefcalcitol

    Pefcalcitol, an analog of vitamin D3 (VD3), is an anti-psoriatic drug candidate that is designed to achieve much higher pharmacological effects, such as keratinocyte differentiation, than those of VD3, with fewer...

    Akira Takeiri, Kenji Tanaka, Asako Harada, Kaori Matsuzaki, Mariko Yano, Shigeki Motoyama, Chie Katoh and Masayuki Mishima

    Genes and Environment 2017 39:17

    Published on: 1 June 2017

  5. Research

    Effect of physicochemical character differences on the genotoxic potency of kaolin

    Kaolin is white clay mineral with the chemical composition Al2Si2O5(OH)4, and many varieties of kaolins having different crystal structures are utilized in industrial, cosmetic and medical fields. To evaluate the...

    Tatsuya Kato, Tatsushi Toyooka, Yuko Ibuki, Shuichi Masuda, Masatoshi Watanabe and Yukari Totsuka

    Genes and Environment 2017 39:12

    Published on: 1 May 2017

  6. Review

    New insight for metformin against bladder cancer

    International Agency for Research on Cancer (IARC) estimated that bladder cancer is the ninth most common cancer in the world, with 430,000 new cases and 165,000 deaths in 2012. Bladder cancer represents the f...

    Amr Ahmed EL-Arabey

    Genes and Environment 2017 39:13

    Published on: 1 April 2017

  7. Letter to the Editor

    The 10th anniversary of the publication of genes and environment: memoir of establishing the Japanese environmental mutagen society and a proposal for a new collaborative study on mutagenic hormesis

    The Japanese Environmental Mutagen Society (JEMS) was established in 1972 by 147 members, 11 of whom are still on the active list as of May 1, 2016. As one of them, I introduce some historic topics here. These...

    Shizuyo Sutou

    Genes and Environment 2017 39:9

    Published on: 1 March 2017

  8. Review

    Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice

    The consequences of early-life exposure to chemicals in the environment are emerging concerns. Chronic exposure to naturally occurring inorganic arsenic has been known to cause various adverse health effects, ...

    Keiko Nohara, Takehiro Suzuki, Kazuyuki Okamura, Junya Matsushita and Shota Takumi

    Genes and Environment 2017 39:3

    Published on: 1 March 2017

  9. Letter to the Editor

    Evolution of genotoxicity test methods in Japan

    The evolution of methods to assess genotoxicity of test compounds is thought to be one of the important subjects in The Japanese Environmental and Mutagen Society (JEMS). In 1970, the Ministry of Education of...

    Toshio Sofuni

    Genes and Environment 2017 39:15

    Published on: 21 February 2017

  10. Review

    Transgenic rat models for mutagenesis and carcinogenesis

    Rats are a standard experimental animal for cancer bioassay and toxicological research for chemicals. Although the genetic analyses were behind mice, rats have been more frequently used for toxicological resea...

    Takehiko Nohmi, Kenichi Masumura and Naomi Toyoda-Hokaiwado

    Genes and Environment 2017 39:11

    Published on: 1 February 2017

  11. Research

    DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

    Interactions between genes and environment are critical factors for causing cancer in humans. The genotoxicity of environmental chemicals can be enhanced via the modulation of susceptible genes in host human c...

    Yuki Kanemaru, Tetsuya Suzuki, Akira Sassa, Kyomu Matsumoto, Noritaka Adachi, Masamitsu Honma, Satoshi Numazawa and Takehiko Nohmi

    Genes and Environment 2017 39:6

    Published on: 7 January 2017

  12. Research

    Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer

    Cytochrome P450 CYP1A1 helps detoxify the potential carcinogens in tobacco smoke, it was reported that polymorphisms in the coding gene result in variation in the expression and activity levels which alter met...

    Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El-Bastawisy, Mirhane Hassan, Shereen Abd El-Aziz, Mohamed Abdel-Hamid and Amal Saad-Hussein

    Genes and Environment 2017 39:7

    Published on: 7 January 2017

  13. Short report

    Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats

    It is known that fibrous particles of micrometer length, such as carbon nanotubes, which have same dimensions as asbestos, are carcinogenic. Carcinogenicity of nanomaterials is strongly related to inflammatory...

    Katsuyoshi Horibata, Akiko Ukai, Akio Ogata, Dai Nakae, Hiroshi Ando, Yoshikazu Kubo, Akemichi Nagasawa, Katsuhiro Yuzawa and Masamitsu Honma

    Genes and Environment 2017 39:4

    Published on: 6 January 2017

  14. Review

    Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

    Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major products is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). The mutagenic potentials of this oxidized base have been exa...

    Tetsuya Suzuki and Hiroyuki Kamiya

    Genes and Environment 2016 39:2

    Published on: 1 December 2016

    The Erratum to this article has been published in Genes and Environment 2017 39:20

  15. Research

    Selective enhancing effect of metal ions on mutagenicity

    We investigated the enhancing effect of metal ions on several mutagens and examined their mechanism of action. We performed the Ames tests on six mutagens, i.e., 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, 4-ni...

    Nobuyoshi Fujii, Shigemitsu Yano and Kenji Takeshita

    Genes and Environment 2016 38:21

    Published on: 1 November 2016

  16. Commentary

    Genotoxicity assessment of 4-methylimidazole: regulatory perspectives

    4-Methylimidazole (4-MI) is formed as a result of the Maillard reaction process, and therefore is found in many foods and beverages. It is also found in soft drinks (i.e., cola) as a by-product in the producti...

    Takeshi Morita and Chikako Uneyama

    Genes and Environment 2016 38:20

    Published on: 1 November 2016

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